Mus musculus

Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Autosomal dominant polycystic kidney disease

Male

Slide-seqv2

Danio rerio

Glutamatergic neuron Endocrine cell Glial cell Neuron Purkinje cell Gabaergic neuron Neural progenitor cell

Adenohypophysis Telencephalon Posterior neural tube Multicellular anatomical structure Cerebellum Neural crest Floor plate

Pharyngula:prim-15 Hatching:long-pec Larval:protruding-mouth Pharyngula:prim-25 Segmentation:26+ somites Segmentation:14-19 somites Hatching:pec-fin Segmentation:20-25 somites Pharyngula:high-pec Pharyngula:prim-5

Normal

Sci-rna-seq3

Nucleus

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Choroid plexus epithelial cell Bergmann glial cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Purkinje cell Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast

Nucleus of medulla oblongata

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Kidney cell Neutrophil Podocyte Natural killer cell Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Erythroid lineage cell Epithelial cell of proximal tubule Plasmacytoid dendritic cell Lymphocyte Macrophage Kidney loop of henle epithelial cell Cd4-positive, alpha-beta t cell Kidney epithelial cell Mesenchymal cell Megakaryocyte B cell Neuron Mesenchymal stem cell Monocyte Myofibroblast cell Conventional dendritic cell Fibroblast

Kidney

13th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage 9th week post-fertilization stage 10th week post-fertilization stage Embryonic stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Neutrophil Natural killer cell Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Erythroid lineage cell Epithelial cell of nephron Epithelial cell of proximal tubule Plasmacytoid dendritic cell Macrophage Kidney connecting tubule epithelial cell Innate lymphoid cell Epithelial cell of glomerular capsule Kidney interstitial cell Cd4-positive, alpha-beta t cell Megakaryocyte Kidney collecting duct cell B cell Mesenchymal stem cell Nephron tubule epithelial cell Monocyte Conventional dendritic cell

Kidney

13th week post-fertilization stage 14th week post-fertilization stage 17th week post-fertilization stage 9th week post-fertilization stage 10th week post-fertilization stage Organogenesis stage

Normal

Female Male

10x 3' v2

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

T cell Neutrophil Granulocyte Natural killer cell Erythroid progenitor cell Erythrocyte Endothelial cell Mature nk t cell Hematopoietic precursor cell Cd8-positive, alpha-beta t cell Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell Myeloid dendritic cell Macrophage Regulatory t cell Hematopoietic stem cell Common myeloid progenitor Plasma cell Cd4-positive, alpha-beta t cell B cell Monocyte Basophil Fibroblast Non-classical monocyte

Bone marrow

42-year-old stage 61-year-old stage 56-year-old stage 59-year-old stage 45-year-old stage 60-year-old stage 22-year-old stage

Normal

Female Male

10x 5' v2 Smart-seq2 10x 3' v3

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron

Lateral nuclear group of thalamus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Tracheal epithelial cell

Tracheal epithelial cell

Mature stage

Normal

10x 3' v3

Cell

Homo sapiens

Cardiac pacemaker cell of sinoatrial node Neutrophil Endocardial cell Dendritic cell, human Endothelial cell of lymphatic vessel Activated cd4-positive, alpha-beta t cell Endothelial cell Mast cell Cd8-positive, alpha-beta t cell Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Smooth muscle cell of the pulmonary artery Adipocyte Cd8-positive, alpha-beta cytotoxic t cell Macrophage Glial cell Plasma cell Vein endothelial cell Cd14-positive monocyte Cd14-low, cd16-positive monocyte B cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Regular atrial cardiac myocyte Monocyte Fibroblast of cardiac tissue Cd16-negative, cd56-bright natural killer cell, human

Sinoatrial node

Fifth decade stage Third decade stage

Normal

Female Male

Visium spatial gene expression v1