Homo sapiens

Stromal cell Endothelial cell of lymphatic vessel Endothelial cell Leukocyte Smooth muscle cell Pericyte

Ovary

65-year-old stage 72-year-old stage 58-year-old stage 62-year-old stage 70-year-old stage

Normal

Female

10x 3' v3 Drop-seq

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Bergmann glial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast Mammillary body neuron

Dorsal tegmental nucleus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Malignant cell

Lung Caecum Peritoneum Liver Hepatic flexure of colon Rectum Transverse colon Chest wall Descending colon Sigmoid colon

37-year-old stage 75-year-old stage 65-year-old stage 53-year-old stage 52-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 44-year-old stage 55-year-old stage 50-year-old stage 74-year-old stage 49-year-old stage 35-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 73-year-old stage 40-year-old stage

Colorectal cancer

Female Male

10x 3' v3

Cell

Homo sapiens

Cardiac ventricle fibroblast

Apex of heart Heart left ventricle

21-year-old stage 26-year-old stage Sixth decade stage 61-year-old stage 52-year-old stage 30-year-old stage 29-year-old stage 38-year-old stage Fifth decade stage 55-year-old stage 28-year-old stage Third decade stage 49-year-old stage 24-year-old stage Seventh decade stage 25-year-old stage 32-year-old stage 64-year-old stage 70-year-old stage 31-year-old stage 19-year-old stage Eighth decade stage 27-year-old stage

Myocarditis Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Cd8-positive, alpha-beta t cell Cd4-positive helper t cell Regulatory t cell Myeloid cell B cell Dendritic cell

Lymph node

Adult stage

Normal

Slide-seqv2

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Off-bipolar cell On-bipolar cell

Peripheral region of retina Fovea centralis

69-year-old stage 65-year-old stage 53-year-old stage 74-year-old stage 64-year-old stage 60-year-old stage 78-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Pericyte Cerebral cortex neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Fibroblast Medium spiny neuron

Pretectal region

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Adipocyte

Subcutaneous adipose tissue Omental fat pad

53-year-old stage 68-year-old stage 29-year-old stage 51-year-old stage 57-year-old stage 24-year-old stage 35-year-old stage 58-year-old stage 41-year-old stage 36-year-old stage 73-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Cardiac endothelial cell Natural killer cell Erythrocyte Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Platelet Smooth muscle cell Plasmacytoid dendritic cell Macrophage Ventricular cardiac muscle cell Plasma cell Cd4-positive, alpha-beta t cell Mesothelial cell B cell Pericyte Neuron Regular atrial cardiac myocyte Monocyte Fibroblast of cardiac tissue

Heart right ventricle Right cardiac atrium Cardiac ventricle Cardiac atrium Heart

61-year-old stage 56-year-old stage 74-year-old stage 59-year-old stage 45-year-old stage 60-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Normal

Male

Slide-seqv2