Mus musculus

Granulosa cell Luteal cell Oocyte

Ovary

3-month-old stage 9-month-old stage

Normal

Female

10x 3' v3

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Neurectodermal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell Anterior visceral endoderm cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Mus musculus

T cell Natural killer cell Endothelial cell Cd8-positive, alpha-beta t cell Epithelial cell Myeloid cell Cd4-positive, alpha-beta t cell Mesenchymal stem cell of adipose tissue B cell

Subcutaneous adipose tissue

3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

Smart-seq2

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Neuroplacodal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Mus musculus

Basal cell of epidermis Keratinocyte

Tongue

3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

Smart-seq2

Cell

Homo sapiens

Neutrophil Mature nk t cell Platelet Myeloid cell Plasma cell B cell Dendritic cell

Blood

66-year-old stage

Covid-19

Female

10x 3' v3

Cell

Homo sapiens

Iga plasma cell Igg plasma cell Memory b cell Plasmablast Naive b cell

Bronchus Lung Trachea Upper lobe of left lung Lower lobe of left lung

66-year-old stage 75-year-old stage Sixth decade stage 29-year-old stage 35-year-old stage Seventh decade stage 58-year-old stage 59-year-old stage 64-year-old stage

Normal

Female Male

10x 5' transcription profiling 10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Pulmonary alveolar type 2 cell

Alveolus of lung

65-year-old stage 61-year-old stage 60-year-old stage 63-year-old stage 73-year-old stage

Pulmonary emphysema Normal

Female Male

10x 3' v3

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Neurectodermal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell Anterior visceral endoderm cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Macaca mulatta

Dopaminergic neuron

Dorsolateral prefrontal cortex Brodmann (1909) area 19 Medial dorsal nucleus of thalamus Primary visual cortex Ventral lateral nucleus of thalamus Inferior temporal gyrus Medulla oblongata Prefrontal cortex Midbrain Entorhinal cortex Nucleus accumbens Cerebrocerebellum Primary somatosensory cortex Primary auditory cortex Primary motor cortex Inferior parietal cortex Head of caudate nucleus Corpus callosum Hippocampal formation Perirhinal cortex Pons Cerebellar vermis Anterior cingulate cortex Superior temporal sulcus Superior parietal cortex Lateral geniculate body Amygdala

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Mus musculus

Retinal ganglion cell Retinal cone cell Glial cell Precursor cell Mueller cell

Normal

Mixed sex

10x 3' v1

Homo sapiens

Ependymal cell Astrocyte

Cervical spinal cord white matter Brodmann (1909) area 4 White matter of cerebellum

37-year-old stage 34-year-old stage 42-year-old stage 71-year-old stage 61-year-old stage 39-year-old stage 44-year-old stage 72-year-old stage 74-year-old stage 45-year-old stage 63-year-old stage 73-year-old stage 40-year-old stage

Normal

Female Male

10x 3' v3

Nucleus