Microcebus murinus

T cell Osteoblast Neutrophil Natural killer cell Erythroid progenitor cell Mature nk t cell Endothelial cell of sinusoid Hematopoietic precursor cell Cd8-positive, alpha-beta t cell Preosteoblast Erythroid lineage cell Plasmacytoid dendritic cell Megakaryocyte progenitor cell Lymphocyte Adipocyte Macrophage Myeloid cell Plasma cell Cd4-positive, alpha-beta t cell Eosinophil B cell Granulocyte monocyte progenitor cell Monocyte Basophil Conventional dendritic cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell

Bone marrow

Post-juvenile adult stage

Normal

Female Male

Smart-seq2 10x 3' v2

Cell

Homo sapiens

Endothelial cell Mature nk t cell Mast cell Epithelial cell Cd8-positive, alpha-beta memory t cell Macrophage Neuronal receptor cell Plasma cell Cd4-positive, alpha-beta memory t cell B cell Monocyte Myofibroblast cell Fibroblast

Right colon

13-year-old stage 17-year-old stage 8-year-old stage 15-year-old stage 9-year-old stage 14-year-old stage 16-year-old stage 10-year-old stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Granulocyte Dendritic cell, human Natural killer cell Cytotoxic t cell Mast cell Natural t-regulatory cell Capillary endothelial cell Classical monocyte Smooth muscle cell Plasmacytoid dendritic cell Macrophage Activated cd8-positive, alpha-beta t cell Fibroblast of lung Plasma cell Malignant cell Cd4-positive, alpha-beta memory t cell Pericyte Epithelial cell of lung Conventional dendritic cell

Lung parenchyma

Adult stage

Lung adenocarcinoma Squamous cell lung carcinoma

10x gene expression flex

Cell

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Cd8-positive, alpha-beta t cell Exhausted t cell Cd4-positive helper t cell Regulatory t cell Myeloid cell Plasma cell Malignant cell B cell

Lung

61-year-old stage

Renal cell carcinoma

Male

Slide-seqv2

Mus musculus

T cell Granulocyte Natural killer cell Mature nk t cell Immature nk t cell Macrophage Macrophage dendritic cell progenitor Plasma cell B cell Megakaryocyte-erythroid progenitor cell Erythroblast Proerythroblast

Spleen

4-week-old stage 3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

T cell Natural killer cell Mast cell Macrophage Alveolar macrophage Plasma cell B cell Monocyte Dendritic cell

Alveolus of lung

65-year-old stage 61-year-old stage 60-year-old stage 63-year-old stage 73-year-old stage

Pulmonary emphysema Normal

Female Male

10x 3' v3

Cell

Homo sapiens

T cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Macrophage Interneuron Bergmann glial cell Neuron Astrocyte

Cerebellum

Pediatric stage

Pilocytic astrocytoma Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Pituitary gland cell

Normal

10x 3' v3

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast

Brodmann (1909) area 23

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Dentate gyrus granule cell Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Pericyte Cerebral cortex neuron Neuron Monocyte Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Hippocampal ca4 neuron

Dentate gyrus of hippocampal formation

42-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell Choroid plexus epithelial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast

Superior parietal cortex

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus