Homo sapiens

Endothelial cell of hepatic sinusoid Hepatocyte Endothelial cell of periportal hepatic sinusoid Hepatic stellate cell Endothelial cell of pericentral hepatic sinusoid Cholangiocyte Vascular associated smooth muscle cell Fibroblast

Liver

66-year-old stage 75-year-old stage 68-year-old stage 55-year-old stage 28-year-old stage 72-year-old stage 49-year-old stage 58-year-old stage Adult stage 67-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage 46-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Drosophila melanogaster

Adult malpighian tubule principal cell of transitional segment Stem cell Fat cell Adult malpighian tubule principal cell of initial segment Adult malpighian tubule principal cell Tracheolar cell Somatic precursor cell Visceral muscle cell Male germline cell Adult renal stem cell Hemocyte Epithelial cell Muscle cell Adult malpighian tubule principal cell of lower segment Adult malpighian tubule principal cell of main segment Adult tracheocyte Adult malpighian tubule principal cell of lower ureter Oenocyte Adult oenocyte Adult malpighian tubule bar-shaped cell of initial segment Adult malpighian tubule stellate cell of main segment

Malpighian tubule

Day 5 of adulthood

Normal

Female Male

10x 3' v3

Homo sapiens

Adipocyte of omentum tissue

Visceral fat

34-year-old stage 53-year-old stage 48-year-old stage 29-year-old stage 28-year-old stage 24-year-old stage Adult stage 33-year-old stage 41-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Endothelial cell of lymphatic vessel Erythrocyte Stem cell of epidermis Melanocyte Endothelial cell of vascular tree Macrophage Skin fibroblast Keratinocyte Pericyte

Zone of skin

69-year-old stage 53-year-old stage 25-year-old stage 70-year-old stage 27-year-old stage

Normal

Male

10x 3' v2

Cell

Mus musculus

Cardiac valve cell Spinal cord interneuron Premigratory neural crest cell Paraxial cell Notochordal cell Neuroplacodal cell Hemangioblast Mesodermal cell Gut endothelial cell Primitive red blood cell Splanchnic mesodermal cell Surface ectodermal cell Midbrain dopaminergic neuron Endodermal cell

Embryo

Theiler stage 14

Normal

Slide-seqv2

Homo sapiens

Endothelial tip cell Endothelial cell of venule Endothelial cell of lymphatic vessel Colon endothelial cell Endothelial cell of artery Capillary endothelial cell Schwann cell Smooth muscle cell Pericyte Myofibroblast cell Fibroblast

Colorectum

69-year-old stage 91-year-old stage 42-year-old stage 89-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 48-year-old stage 56-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 90-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 49-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage 47-year-old stage 76-year-old stage 73-year-old stage

Normal Colon adenocarcinoma

Female Male

10x 3' v3 10x 3' v2

Cell

Mus musculus

Multiciliated ependymal cell Deuterosomal cell Radial glial cell Neuron associated cell

Multiciliated ependymal cell

Theiler stage 27

Normal

10x 3' v3

Cell

Homo sapiens

Pvalb chandelier gabaergic interneuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Mus musculus

Ciliated cell Ependymal cell Choroid plexus epithelial cell

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 14 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 20 Theiler stage 12 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Cd8-positive, alpha-beta t cell Cd4-positive helper t cell Epithelial cell Regulatory t cell Myeloid cell Plasma cell Malignant cell B cell Fibroblast

Lung

61-year-old stage

Renal cell carcinoma

Male

Slide-seqv2

Homo sapiens

T cell Stem cell Paneth cell Enteroendocrine cell Goblet cell Intestinal crypt stem cell Enterocyte

Disease

Seq-well

Mus musculus

Neuron

Normal

10x 3' v2