Homo sapiens

Keratinocyte Epithelial cell Cycling basal cell Glandular cell of esophagus Basal cell

Epithelium of esophagus Esophagus

Sixth decade stage Fourth decade stage 15th week post-fertilization stage Fifth decade stage 31-year-old stage 17th week post-fertilization stage Seventh decade stage

Normal

Female Male

10x 5' transcription profiling 10x 3' v2

Cell

Homo sapiens

Iga plasma cell Secretory cell Fibroblast Innate lymphoid cell Enteroendocrine cell Transit amplifying cell Myeloid cell Germinal center b cell Mast cell Igg plasma cell Glial cell Vein endothelial cell Mural cell Epithelial cell Follicular dendritic cell Dendritic cell B cell Capillary endothelial cell Paneth cell Myofibroblast cell Plasmacytoid dendritic cell Goblet cell Igm plasma cell Endothelial cell of lymphatic vessel Natural killer cell Macrophage Monocyte T cell Epithelial fate stem cell M cell of gut Endothelial cell Endothelial cell of artery

Crohn's colitis

10x 3' v2

Homo sapiens

Kidney loop of henle thin descending limb epithelial cell Cytotoxic t cell Kidney interstitial cell Kidney loop of henle thick ascending limb epithelial cell Parietal epithelial cell Mast cell Epithelial cell of proximal tubule Podocyte Kidney connecting tubule epithelial cell Mononuclear phagocyte Plasma cell B cell Regulatory t cell Non-classical monocyte Kidney interstitial alternatively activated macrophage Plasmacytoid dendritic cell, human Kidney loop of henle thin ascending limb epithelial cell Kidney distal convoluted tubule epithelial cell Natural killer cell Kidney collecting duct intercalated cell Conventional dendritic cell Monocyte Mature nk t cell Kidney collecting duct principal cell T cell Endothelial cell

Kidney

35-year-old stage 39-year-old stage 53-year-old stage Third decade stage 57-year-old stage Sixth decade stage 49-year-old stage 42-year-old stage Fourth decade stage 52-year-old stage 48-year-old stage 40-year-old stage 41-year-old stage Eighth decade stage 30-year-old stage 66-year-old stage Fifth decade stage 31-year-old stage 56-year-old stage Seventh decade stage 47-year-old stage

Chronic kidney disease Acute kidney failure Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Fibroblast Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Vascular associated smooth muscle cell Pericyte Leukocyte Central nervous system macrophage Neuron Endothelial cell

Middle temporal gyrus

42-year-old stage 50-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Fibroblast Neural progenitor cell Astrocyte Neutrophil Oligodendrocyte precursor cell Oligodendrocyte B cell Myeloid leukocyte Pericyte Ependymal cell Macrophage Microglial cell Choroid plexus epithelial cell T cell Neuron Endothelial cell

Brain ischemia Normal

10x 3' v2

Homo sapiens

Fibroblast Helper t cell Mucosal invariant t cell Schwann cell Keratinocyte Mast cell Langerhans cell Melanocyte Neutrophil Plasma cell B cell Gamma-delta t cell Regulatory t cell T-helper 17 cell Vascular associated smooth muscle cell Capillary endothelial cell Merkel cell Pericyte Plasmacytoid dendritic cell Endothelial cell of venule Endothelial cell of lymphatic vessel Natural killer cell Macrophage Conventional dendritic cell Mature nk t cell T cell Endothelial cell of artery

Gingiva

35-year-old stage Adult stage 39-year-old stage 26-year-old stage 21-year-old stage 61-year-old stage 57-year-old stage 42-year-old stage 38-year-old stage 45-year-old stage 30-year-old stage 22-year-old stage 51-year-old stage 29-year-old stage 32-year-old stage 28-year-old stage Young adult stage 31-year-old stage 37-year-old stage 24-year-old stage 44-year-old stage 34-year-old stage

Periodontitis Gingivitis Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Plasmablast Cd16-positive, cd56-dim natural killer cell, human Cd14-low, cd16-positive monocyte Cd4-positive, cd25-positive, alpha-beta regulatory t cell Memory b cell Cd14-positive, cd16-negative classical monocyte Gamma-delta t cell Naive thymus-derived cd4-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Effector cd8-positive, alpha-beta t cell Effector cd4-positive, alpha-beta t cell Cd16-negative, cd56-bright natural killer cell, human Conventional dendritic cell Cd8-positive, alpha-beta memory t cell Naive b cell

Blood

9-year-old stage 13-year-old stage 17-year-old stage 1-year-old stage 7-year-old stage 4-year-old stage 3-year-old stage 14-year-old stage 2-year-old stage 15-year-old stage 18-year-old stage 11-year-old stage 5-year-old stage 8-year-old stage 16-year-old stage

Juvenile dermatomyositis Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Memory t cell Plasma cell B cell Gamma-delta t cell Regulatory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Plasmacytoid dendritic cell Natural killer cell Cd8-positive, alpha-beta memory t cell T cell Cd8-positive, alpha-beta cytotoxic t cell

Liver

Adult stage 73-year-old stage 72-year-old stage 53-year-old stage 49-year-old stage 55-year-old stage 58-year-old stage 75-year-old stage 64-year-old stage 68-year-old stage 66-year-old stage 77-year-old stage 33-year-old stage 28-year-old stage 46-year-old stage 67-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Fibroblast Periportal region hepatocyte Kupffer cell Vein endothelial cell Endothelial cell of periportal hepatic sinusoid Plasma cell Midzonal region hepatocyte Centrilobular region hepatocyte Intrahepatic cholangiocyte Vascular associated smooth muscle cell Hepatic pit cell Macrophage Hepatic stellate cell Monocyte Endothelial cell of pericentral hepatic sinusoid Cd4-positive, alpha-beta t cell

Caudate lobe of liver

Postnatal stage Late adult stage Young adult stage Prime adult stage

Primary sclerosing cholangitis Primary biliary cholangitis Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte precursor cell

Intralaminar nuclear group Primary motor cortex Perirhinal cortex Cerebellar nuclear complex Inferior temporal gyrus Dentate gyrus of hippocampal formation Cerebrocerebellum Primary visual cortex Brodmann (1909) area 35 Ventral anterior nucleus of thalamus Brodmann (1909) area 46 Subthalamic nucleus Globus pallidus Nucleus accumbens Primary somatosensory cortex Midbrain tectum Lateral nuclear group of thalamus Inferior frontal gyrus Epithalamus Cuneus cortex Retrosplenial region Medial dorsal nucleus of thalamus Medial zone of hypothalamus Putamen Lateral geniculate body Brodmann (1909) area 25 Nucleus of medulla oblongata Red nucleus Corticomedial nuclear complex Nucleus of dorsal thalamus Brodmann (1909) area 14 Pontine reticular formation Brodmann (1909) area 19 Midbrain nucleus Piriform cortex Pontine tegmentum Accessory basal amygdaloid nucleus Anterior olfactory nucleus Hypothalamus Granular insular cortex Centromedian nucleus of thalamus Brodmann (1909) area 32 Superior temporal gyrus Substantia nigra Primary auditory cortex Brodmann (1909) area 24 Cerebellar vermis Uncal ca1 Anterior cortical amygdaloid nucleus Lateral entorhinal cortex Septal nuclear complex Basolateral amygdaloid nuclear complex Spinal cord Preoptic area Middle temporal gyrus Parabrachial nucleus Brodmann (1909) area 38 Agranular insular cortex Pulvinar nucleus Body of caudate nucleus Temporal fusiform gyrus Extrastriate cortex Brodmann (1909) area 23 Medial entorhinal cortex Lateral amygdaloid nucleus Supraoptic nucleus Posterior parahippocampal gyrus Pontine nuclear group Median tuberal portion Superior parietal cortex Dorsal tegmental nucleus Substantia innominata Bed nucleus of stria terminalis Brodmann (1909) area 13 Medial geniculate body Inferior olivary complex Gray matter of midbrain Mammillary body Anterior nuclear group Central amygdaloid nucleus Subicular complex Brodmann (1909) area 43 Hippocampal field Rostral ca3 Brodmann (1909) area 40 Claustrum of brain Pretectal region Lateral posterior nucleus of thalamus

42-year-old stage 50-year-old stage 29-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Astrocyte Dopaminergic neuron Gabaergic neuron Immature astrocyte Neutrophil Oligodendrocyte precursor cell Oligodendrocyte Dendritic cell B cell Vascular associated smooth muscle cell Olfactory ensheathing cell Hypendymal cell Cholinergic neuron Pericyte Arachnoid barrier cell Ependymal cell Glutamatergic neuron Natural killer cell Macrophage Neuroendocrine cell Tanycyte Neural stem cell Monocyte Vascular leptomeningeal cell Microglial cell Choroid plexus epithelial cell T cell Endothelial cell

Normal

10x 3' v2

Homo sapiens

Vip gabaergic interneuron

Middle temporal gyrus

Adult stage 78-year-old stage 80 year-old and over stage 72-year-old stage 83-year-old stage 85-year-old stage 81-year-old stage 82-year-old stage 86-year-old stage 70-year-old stage 75-year-old stage 50-year-old stage 89-year-old stage 68-year-old stage 29-year-old stage 77-year-old stage 69-year-old stage 88-year-old stage 87-year-old stage 60-year-old stage 80-year-old stage 84-year-old stage 43-year-old stage 65-year-old stage

Dementia Normal

Female Male

10x multiome 10x 3' v3

Nucleus