Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

78-year-old stage 80 year-old and over stage 72-year-old stage 83-year-old stage 85-year-old stage 81-year-old stage 82-year-old stage 42-year-old stage 86-year-old stage 70-year-old stage 75-year-old stage 50-year-old stage 89-year-old stage 68-year-old stage 29-year-old stage 77-year-old stage 69-year-old stage 88-year-old stage 87-year-old stage 80-year-old stage 84-year-old stage

Dementia Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Dopaminergic neuron Neuron

Substantia nigra pars compacta

90-year-old stage 82-year-old stage 49-year-old stage 79-year-old stage 91-year-old stage 92-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Fibroblast Endothelial cell of vascular tree Vein endothelial cell Vascular associated smooth muscle cell Capillary endothelial cell Pericyte Myofibroblast cell Cycling stromal cell Endothelial cell Endothelial cell of artery

Breast

54-year-old stage 35-year-old stage Adult stage 62-year-old stage 80 year-old and over stage 73-year-old stage Ninth decade stage 83-year-old stage 85-year-old stage 61-year-old stage 57-year-old stage Sixth decade stage 82-year-old stage 49-year-old stage 42-year-old stage 36-year-old stage 52-year-old stage 70-year-old stage 38-year-old stage 45-year-old stage 41-year-old stage 59-year-old stage Eighth decade stage 30-year-old stage 55-year-old stage 58-year-old stage 50-year-old stage 64-year-old stage 29-year-old stage 66-year-old stage Late adult stage 69-year-old stage 32-year-old stage Fifth decade stage 88-year-old stage 63-year-old stage 60-year-old stage 80-year-old stage Prime adult stage 84-year-old stage 25-year-old stage Middle aged stage 46-year-old stage 67-year-old stage 43-year-old stage 60-79 year-old stage 65-year-old stage 71-year-old stage Seventh decade stage 47-year-old stage

Invasive lobular breast carcinoma Breast apocrine carcinoma Her2 positive breast carcinoma Breast mucinous carcinoma Breast carcinoma Triple-negative breast carcinoma Invasive ductal breast carcinoma Invasive tubular breast carcinoma Breast cancer Metaplastic breast carcinoma Estrogen-receptor positive breast cancer

Female Male

10x 5' transcription profiling 10x 3' v3 10x 5' v2 10x 5' v1 10x 3' v2

Cell

Mus musculus

Parasympathetic neuron Peripheral nervous system neuron Sympathetic neuron Spiral ganglion neuron Sensory neuron of dorsal root ganglion Enteric neuron

Embryo

Theiler stage 26 Theiler stage 18 Theiler stage 13 Theiler stage 24 Theiler stage 15 Theiler stage 14 Theiler stage 12 Theiler stage 23 Theiler stage 20 Theiler stage 22 Theiler stage 16 Theiler stage 21 Theiler stage 25 Theiler stage 27 Theiler stage 17 Theiler stage 19

Normal

Female Male

Sci-rna-seq3

Nucleus

Mus musculus

Neural progenitor cell Astrocyte Leptomeningeal cell Gabaergic neuron Oligodendrocyte precursor cell Oligodendrocyte Pericyte Glutamatergic neuron Microglial cell Endothelial cell

Primary motor cortex Dentate gyrus of hippocampal formation Nucleus accumbens Primary somatosensory cortex Neocortex Lateral septal complex Cerebral cortex Piriform cortex Anterior olfactory nucleus Pallidum Primary auditory cortex Olfactory cortex Prefrontal cortex Secondary somatosensory cortex Caudate-putamen Hippocampal field Orbitofrontal cortex

8-week-old stage

Normal

Male

Snmc-seq2

Nucleus

Mus musculus

Neural progenitor cell Astrocyte Leptomeningeal cell Gabaergic neuron Oligodendrocyte precursor cell Oligodendrocyte Pericyte Glutamatergic neuron Microglial cell Endothelial cell

Primary motor cortex Dentate gyrus of hippocampal formation Nucleus accumbens Primary somatosensory cortex Neocortex Lateral septal complex Cerebral cortex Piriform cortex Anterior olfactory nucleus Pallidum Primary auditory cortex Olfactory cortex Prefrontal cortex Secondary somatosensory cortex Caudate-putamen Hippocampal field Orbitofrontal cortex

8-week-old stage

Normal

Male

Snmc-seq2

Nucleus

Homo sapiens

Fibroblast Primitive red blood cell Basophil mast progenitor cell Schwann cell Common myeloid progenitor Osteoclast Hematopoietic multipotent progenitor cell Macrophage dendritic cell progenitor Mast cell Early lymphoid progenitor Myeloid lineage restricted progenitor cell Cd14-positive monocyte Fraction a pre-pro b cell Lymphoid lineage restricted progenitor cell Precursor cell Immature natural killer cell Basophil Neutrophil Pro-b cell Common dendritic progenitor Immature b cell Dendritic cell Regulatory t cell Chondrocyte Megakaryocyte Endothelial tip cell Endothelial cell of sinusoid Endosteal cell Myofibroblast cell Immature innate lymphoid cell Precursor b cell Plasmacytoid dendritic cell Muscle cell Preosteoblast Eosinophil Progenitor cell Adipocyte Muscle precursor cell Cd8-positive, alpha-beta t cell Promonocyte Megakaryocyte-erythroid progenitor cell Cd16-negative, cd56-bright natural killer cell, human Granulocyte monocyte progenitor cell Natural killer cell Macrophage Myelocyte Erythrocyte Osteoblast Mature nk t cell Promyelocyte Cd4-positive, alpha-beta t cell Naive b cell Endothelial cell

Bone marrow

14th week post-fertilization stage 16th week post-fertilization stage 19th week post-fertilization stage 15th week post-fertilization stage 13th week post-fertilization stage 17th week post-fertilization stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Mature t cell

Multiple sclerosis Myasthenia gravis Systemic lupus erythematosus Normal

10x 5' v2

Mus musculus

Myotendinous junction nucleus Fibro/adipogenic progenitor cell Schwann cell Smooth muscle cell Blood vessel endothelial cell Intermediate muscle cell Type iia muscle cell Pericyte Neuromuscular junction nucleus Skeletal muscle satellite stem cell Type iix muscle cell Lymphocyte Adipocyte Perineurial cell Tendon cell Microvascular endothelial cell Macrophage Type iib muscle cell

Skeletal muscle tissue of tibialis anterior Gastrocnemius

Prime adult stage

Toxin-mediated infectious botulism Neuromuscular junction disease Lesion of sciatic nerve Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Fibroblast Muscle fibroblast Fibroblast of dermis Articular chondrocyte Smooth muscle cell Chondroblast Mesenchymal cell Chondrocyte Pericyte Tendon cell Hypertrophic chondrocyte Osteoblast Connective tissue cell

Forelimb Hindlimb

Carnegie stage 19 Carnegie stage 18 10th week post-fertilization stage Carnegie stage 23 Carnegie stage 15 Carnegie stage 17 9th week post-fertilization stage Carnegie stage 16

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Perivascular cell Astrocyte Gabaergic neuron Oligodendrocyte precursor cell Oligodendrocyte Pericyte Ependymal cell Glutamatergic neuron Vascular leptomeningeal cell Microglial cell Endothelial cell

Dorsolateral prefrontal cortex Hippocampal formation Anterior cingulate cortex Caudate nucleus

39-year-old stage 62-year-old stage 61-year-old stage Infant stage 4-year-old stage 6-year-old stage 14-year-old stage 20-year-old stage

Normal

Female Male

10x multiome

Nucleus

Mus musculus

Gabaergic neuron Brain microvascular endothelial cell Oligodendrocyte Smooth muscle cell of the brain vasculature Lymphocyte Glutamatergic neuron Forebrain neuroblast Medium spiny neuron Vascular leptomeningeal cell Microglial cell Choroid plexus epithelial cell

Prion disease Normal

10x 3' transcription profiling