Mus musculus

Skin fibroblast

Skin of back Skin of body

5-week-old stage 9-week-old stage 12-month-old stage 21-day-old stage Prime adult stage 7-week-old stage 18-month-old stage 22-day-old stage 2-month-old stage

Normal Injury

Female Male

10x 3' v1 10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell Club cell Blood vessel endothelial cell Ciliated cell Natural killer cell Endothelial cell Mast cell Pulmonary neuroendocrine cell Basal cell Endothelial cell of artery Smooth muscle cell Epithelial cell Goblet cell Macrophage Pulmonary alveolar type 1 cell Alveolar macrophage Vein endothelial cell B cell Pericyte Monocyte Vascular associated smooth muscle cell Myofibroblast cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell Enucleate erythrocyte Chondrocyte

Lung

31st week post-fertilization stage 3-year-old stage 31-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Dentate gyrus granule cell Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Choroid plexus epithelial cell Bergmann glial cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron Hippocampal ca4 neuron

Pulvinar nucleus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Effector cd8-positive, alpha-beta t cell Gamma-delta t cell Exhausted t cell Cd4-positive helper t cell Cd8-positive, alpha-beta memory t cell Regulatory t cell

Adrenal gland Axilla Bone spine Brain Liver Lung Lymph node Pleural effusion

69-year-old stage 75-year-old stage 65-year-old stage 71-year-old stage 85-year-old stage 68-year-old stage 44-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 80-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 78-year-old stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage

Lung adenocarcinoma Normal Small cell lung carcinoma

Female Male

10x 3' transcription profiling 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Cardiac endothelial cell Lymphoid lineage restricted progenitor cell Immature innate lymphoid cell Neuronal receptor cell Pericyte Cardiac muscle myoblast Smooth muscle myoblast Fibroblast of cardiac tissue

Heart left ventricle

66-year-old stage 43-year-old stage 61-year-old stage 52-year-old stage 44-year-old stage 38-year-old stage 55-year-old stage 51-year-old stage 57-year-old stage 74-year-old stage 58-year-old stage 59-year-old stage 64-year-old stage 60-year-old stage 63-year-old stage 47-year-old stage 40-year-old stage

Normal Myocardial infarction

Female Male

10x scatac-seq

Nucleus

Mus musculus

Neural stem cell Glutamatergic neuron Direct pathway medium spiny neuron Endothelial cell Oligodendrocyte Contractile cell Vascular leptomeningeal cell Cholinergic neuron Neural cell Ependymal cell Microglial cell Neuroblast (sensu vertebrata) Neuron associated cell Interneuron Indirect pathway medium spiny neuron Striosomal d1 medium spiny neuron Astrocyte

Postnatal subventricular zone

5-week-old stage

Normal

Mixed sex

10x genomics v2

Homo sapiens

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Inhibitory interneuron Medial ganglionic eminence derived interneuron Microglial cell Radial glial cell Pericyte Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Neural progenitor cell

Cortical plate Dorsolateral prefrontal cortex

19th week post-fertilization stage 23rd week post-fertilization stage 39-year-old stage 14-year-old stage 18th week post-fertilization stage Infant stage 20-year-old stage 24th week post-fertilization stage 6-year-old stage 4-year-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Central nervous system macrophage Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Committed oligodendrocyte precursor Endothelial cell of artery Capillary endothelial cell Cerebellar granule cell Leukocyte Microglial cell Mural cell Neuron Vascular associated smooth muscle cell Astrocyte Gabaergic neuron

Brodmann (1909) area 4 Cervical spinal cord white matter White matter of cerebellum

37-year-old stage 34-year-old stage 42-year-old stage 71-year-old stage 61-year-old stage 39-year-old stage 44-year-old stage 72-year-old stage 74-year-old stage 45-year-old stage 63-year-old stage 73-year-old stage 40-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Centromedian nucleus of thalamus Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Median tuberal portion Midbrain tectum Middle temporal gyrus Nucleus accumbens Nucleus of dorsal thalamus Nucleus of medulla oblongata Perirhinal cortex Piriform cortex Pontine nuclear group Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Rostral ca3 Septal nuclear complex Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Uncal ca1 Ventral anterior nucleus of thalamus

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Ciliated cell Secretory cell Endothelial cell Mast cell Basal cell of olfactory epithelium Goblet cell Macrophage Myeloid cell Plasma cell Glandular secretory epithelial cell Eosinophil Fibroblast

Normal Chronic rhinitis

Seq-well

Homo sapiens

Igg plasmablast Effector cd8-positive, alpha-beta t cell Neutrophil Granulocyte Natural killer cell Erythrocyte Gamma-delta t cell Platelet Plasmacytoid dendritic cell Cd8-positive, alpha-beta memory t cell Iga plasmablast Cd4-positive, alpha-beta t cell Cd14-positive monocyte Cd4-positive, alpha-beta memory t cell B cell Naive t cell Monocyte Conventional dendritic cell Class switched memory b cell

Blood

37-year-old stage Sixth decade stage 48-year-old stage Fifth decade stage Third decade stage 80 year-old and over stage 49-year-old stage Seventh decade stage 36-year-old stage Fourth decade stage

Covid-19 Normal

Female Male

Seq-well

Cell