Homo sapiens

T cell Neutrophil Epithelial cell Obsolete animal cell Macrophage Eosinophil B cell Fibroblast Dendritic cell

Normal

Seq-well

Homo sapiens

Central memory cd4-positive, alpha-beta t cell Neutrophil Activated cd4-positive, alpha-beta t cell, human Natural killer cell Erythrocyte Platelet Classical monocyte Plasmacytoid dendritic cell, human Lymphocyte Cd4-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Activated cd8-positive, alpha-beta t cell, human Memory b cell Regulatory t cell Plasmablast Hematopoietic stem cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Transitional stage b cell Naive b cell Conventional dendritic cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Immature neutrophil Non-classical monocyte

Blood

75-year-old stage 53-year-old stage 68-year-old stage 48-year-old stage 38-year-old stage 84-year-old stage 80 year-old and over stage 59-year-old stage 70-year-old stage 60-year-old stage 47-year-old stage

Covid-19 Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Choroid plexus epithelial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast Mammillary body neuron

Midbrain nucleus

42-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Lymphocyte of b lineage Natural killer cell Macrophage Myeloid cell Malignant cell Mesothelial cell Dendritic cell

Pleural effusion

Adult stage

Triple-negative breast carcinoma Luminal b breast carcinoma Luminal a breast carcinoma

10x 3' v3

Cell

Homo sapiens

Natural killer cell Erythroid progenitor cell Small pre-b-ii cell Gamma-delta t cell Pro-b cell Erythroid lineage cell Classical monocyte Pre-natural killer cell Plasmacytoid dendritic cell Precursor b cell Lymphoid lineage restricted progenitor cell Basophil mast progenitor cell Megakaryocyte progenitor cell Common dendritic progenitor Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Unswitched memory b cell Memory b cell Cd16-positive, cd56-dim natural killer cell, human Myelocyte Plasma cell Late promyelocyte Mesenchymal cell Hematopoietic multipotent progenitor cell Cd4-positive, alpha-beta memory t cell Progenitor cell Naive thymus-derived cd4-positive, alpha-beta t cell Early promyelocyte Immature b cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Central memory cd8-positive, alpha-beta t cell Naive b cell Conventional dendritic cell Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Bone marrow

69-year-old stage 34-year-old stage 65-year-old stage 26-year-old stage 59-year-old stage 25-year-old stage

Normal

Female Male

Bd rhapsody targeted mrna

Cell

Homo sapiens

T cell Neutrophil Stromal cell Endothelial cell Mature nk t cell Stromal cell of ovary Hematopoietic precursor cell Mast cell Cd8-positive, alpha-beta t cell Blood vessel smooth muscle cell Leukocyte Classical monocyte Smooth muscle cell Epithelial cell Plasmacytoid dendritic cell Myeloid dendritic cell Ovarian surface epithelial cell Macrophage Glial cell Plasma cell Cd4-positive, alpha-beta t cell Glandular secretory epithelial cell Oocyte B cell Monocyte Theca cell

Left ovary Ovary Right ovary

26-year-old stage 56-year-old stage 55-year-old stage

Normal

Female

Smart-seq3 Smart-seq2 10x 3' v3

Cell

Macaca mulatta

Medium spiny neuron

Dorsolateral prefrontal cortex Brodmann (1909) area 19 Medial dorsal nucleus of thalamus Primary visual cortex Ventral lateral nucleus of thalamus Inferior temporal gyrus Medulla oblongata Prefrontal cortex Midbrain Entorhinal cortex Nucleus accumbens Cerebrocerebellum Primary somatosensory cortex Primary auditory cortex Primary motor cortex Inferior parietal cortex Head of caudate nucleus Corpus callosum Hippocampal formation Perirhinal cortex Pons Cerebellar vermis Anterior cingulate cortex Superior temporal sulcus Superior parietal cortex Lateral geniculate body Amygdala

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Cultured cell

Calu-3

Covid-19 Normal Severe acute respiratory syndrome

Drop-seq

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Dentate gyrus granule cell Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Microglial cell Thalamic excitatory neuron Choroid plexus epithelial cell B cell Pericyte Cerebral cortex neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast Medium spiny neuron

Lateral geniculate body

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Podocyte Natural killer cell Parietal epithelial cell Cytotoxic t cell Renal interstitial pericyte Endothelial cell Kidney loop of henle thin descending limb epithelial cell Mature nk t cell Kidney interstitial fibroblast Mast cell Kidney collecting duct intercalated cell Leukocyte Epithelial cell of proximal tubule Epithelial cell Plasmacytoid dendritic cell Alternatively activated macrophage Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney connecting tubule epithelial cell Kidney loop of henle thick ascending limb epithelial cell Plasma cell B cell Monocyte Kidney loop of henle thin ascending limb epithelial cell Myofibroblast cell Conventional dendritic cell Non-classical monocyte

Cortex of kidney

69-year-old stage 43-year-old stage 71-year-old stage 53-year-old stage 68-year-old stage 50-year-old stage 57-year-old stage 72-year-old stage 74-year-old stage 58-year-old stage 59-year-old stage 67-year-old stage 46-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Respiratory tract goblet cell Seromucus secreting cell Alpha-beta t cell Ionocyte Respiratory tract epithelial cell Macrophage Deuterosomal cell Respiratory basal cell Squamous epithelial cell B cell Respiratory tract multiciliated cell Monocyte Dendritic cell

Covid-19 Normal

Seq-well

Homo sapiens

T cell Neutrophil Epithelial cell Macrophage Eosinophil B cell Fibroblast Dendritic cell

Milk

34-year-old stage 29-year-old stage 35-year-old stage 32-year-old stage 33-year-old stage 31-year-old stage

Normal

Female

Seq-well

Cell