Mus musculus

Endothelial cell of lymphatic vessel Endothelial cell Interstitial cell of cajal Smooth muscle cell Glial cell Pericyte Fibroblast

Normal

10x 3' v2

Homo sapiens

Blood vessel endothelial cell Ciliary muscle cell Schwann cell Melanocyte Lymphocyte Non-pigmented ciliary epithelial cell Macrophage Pigmented ciliary epithelial cell Pericyte Fibroblast

Ciliary body

66-year-old stage 30-year-old stage 78-year-old stage 47-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Normal

Male

Slide-seqv2

Microcebus murinus

T cell Neutrophil Club cell Ciliated cell Natural killer cell Endothelial cell of lymphatic vessel Erythroid progenitor cell Non-myelinating schwann cell Endothelial cell Mature nk t cell Hematopoietic precursor cell Cd8-positive, alpha-beta t cell Platelet Erythroid lineage cell Endothelial cell of artery Capillary endothelial cell Plasmacytoid dendritic cell Megakaryocyte progenitor cell Lymphocyte Macrophage Innate lymphoid cell Pulmonary alveolar type 1 cell Brush cell of bronchus Fibroblast of lung Alveolar macrophage Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Eosinophil Epithelial cell of uterus Mesothelial cell B cell Pericyte Granulocyte monocyte progenitor cell Monocyte Vascular associated smooth muscle cell Myofibroblast cell Basophil Conventional dendritic cell Fibroblast Myelinating schwann cell Dendritic cell Pulmonary alveolar type 2 cell Basal cell of epithelium of bronchus

Lung

Post-juvenile adult stage

Normal

Female Male

Smart-seq2 10x 3' v2

Cell

Homo sapiens

T cell Central nervous system macrophage Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Sst chodl gabaergic interneuron Astrocyte Fibroblast Hippocampal ca4 neuron

Retrosplenial region

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Eccentric medium spiny neuron Medial ganglionic eminence derived interneuron Microglial cell Thalamic excitatory neuron B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron

Globus pallidus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Sus scrofa

Natural killer cell Plasmacytoid dendritic cell Hematopoietic lineage restricted progenitor cell B cell Conventional dendritic cell Dendritic cell

Blood

Prime adult stage

Normal

Female

10x 3' v3

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Thalamic excitatory neuron B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast

Gray matter of midbrain

42-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Neutrophil Cell Natural killer cell Gamma-delta t cell Mast cell Cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Macrophage Regulatory t cell Monocyte-derived dendritic cell Plasma cell Cd4-positive, alpha-beta t cell Type i nk t cell Eosinophil B cell Monocyte Conventional dendritic cell Osteoclast Dendritic cell

Cutaneous melanoma

10x 5' transcription profiling

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Microglial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Purkinje cell Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast

Pontine nuclear group

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Ependymal cell Astrocyte

Substantia nigra pars compacta

75-year-old stage 91-year-old stage 89-year-old stage 92-year-old stage 82-year-old stage 90-year-old stage 74-year-old stage 49-year-old stage 70-year-old stage 78-year-old stage 76-year-old stage 79-year-old stage 83-year-old stage

Parkinson disease Normal Lewy body dementia

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast

Primary visual cortex

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus