Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Cd4-positive helper t cell

Normal

10x scatac-seq

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Neocortex

Adult stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell B cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast

Temporal fusiform gyrus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Endothelial cell of lymphatic vessel Endocrine cell Luminal adaptive secretory precursor cell of mammary gland Basal-myoepithelial cell of mammary gland Luminal hormone-sensing cell of mammary gland B cell

Upper outer quadrant of breast

21-year-old stage 42-year-old stage 43-year-old stage 44-year-old stage 35-year-old stage Adult stage 60-year-old stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Drosophila melanogaster

Neuron Fat cell Cardial cell Tracheolar cell Glial cell Somatic precursor cell Male germline cell Hemocyte Epithelial cell Adult alary muscle cell Muscle cell Adult neuron Sensory neuron Oenocyte Adult oenocyte Neuron Female germline cell

Fat body

Day 3 of adulthood

Normal

Female Male

10x 3' v3

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Natural killer cell Erythroid progenitor cell Gamma-delta t cell Pro-b cell Erythroid lineage cell Classical monocyte Pre-natural killer cell Plasmacytoid dendritic cell Precursor b cell Lymphoid lineage restricted progenitor cell Basophil mast progenitor cell Megakaryocyte progenitor cell Common dendritic progenitor Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Unswitched memory b cell Memory b cell Cd16-positive, cd56-dim natural killer cell, human Myelocyte Plasma cell Late promyelocyte Mesenchymal cell Hematopoietic multipotent progenitor cell Cd4-positive, alpha-beta memory t cell Progenitor cell Naive thymus-derived cd4-positive, alpha-beta t cell Early promyelocyte Immature b cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Central memory cd8-positive, alpha-beta t cell Naive b cell Conventional dendritic cell Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Bone marrow

66-year-old stage 71-year-old stage 61-year-old stage 54-year-old stage 44-year-old stage 56-year-old stage 55-year-old stage 51-year-old stage 32-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 78-year-old stage

Acute myeloid leukemia Acute promyelocytic leukemia

Female Male

Bd rhapsody targeted mrna

Cell

Homo sapiens

Neutrophil Blood vessel endothelial cell Natural killer cell Endothelial cell of lymphatic vessel Cd8-positive, alpha-beta t cell Adult skeletal muscle myoblast Cd4-positive helper t cell Ionocyte Myoepithelial cell Macrophage Mural cell Keratinocyte Acinar cell of salivary gland Plasma cell Salivary gland glandular cell B cell Fibroblast Dendritic cell

Minor salivary gland

34-year-old stage 26-year-old stage 53-year-old stage 48-year-old stage 39-year-old stage 56-year-old stage 28-year-old stage 24-year-old stage 40-year-old stage

Normal

Female Male

10x 3' v3

Cell

Drosophila melanogaster

Ovarian sheath muscle cell

Ovary

Day 5 of adulthood

Normal

Female

10x 3' v3

Mus musculus

Oligodendrocyte precursor cell Committed oligodendrocyte precursor

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 25 Theiler stage 19 Theiler stage 26 Theiler stage 20 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus