Homo sapiens

Stromal cell

Lamina propria of small intestine Lamina propria of large intestine

80-year-old stage 59-year-old stage

Normal

Female

10x 5' v2

Cell

Callithrix jacchus

Neuron

Anterior hypothalamic region Posterior hypothalamic region

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Mus musculus

Supporting cell Erythrocyte Endothelial cell Sertoli cell Leukocyte Epithelial cell Neural cell Mesenchymal cell Germ cell Pericyte Leydig cell Skeletal muscle fiber

Gonad

Theiler stage 19 Theiler stage 20 Theiler stage 21

Normal

Male

10x 5' v1

Cell

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Dentate gyrus granule cell Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell B cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron

Primary auditory cortex

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell B cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast

Lateral entorhinal cortex

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Homo sapiens

Central nervous system macrophage Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Lamp5 lhx6 neuron Eccentric medium spiny neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron

Body of caudate nucleus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Microglial cell Pericyte Cerebral cortex neuron Near-projecting glutamatergic cortical neuron Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast

Extrastriate cortex

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Oligodendrocyte precursor cell Oligodendrocyte Schwann cell

Spinal cord

3-6 month-old mature stage

Spinal cord injury Normal

Female

10x 3' v2

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell T cell Natural killer cell Follicular dendritic cell Centrocyte Cd4-positive helper t cell Plasmacytoid dendritic cell Cd8-positive, alpha-beta cytotoxic t cell Centroblast Macrophage Memory b cell Innate lymphoid cell Regulatory t cell Mature b cell Myeloid cell Plasmablast T follicular regulatory cell T follicular helper cell Central memory cd8-positive, alpha-beta t cell Naive b cell Conventional dendritic cell Tonsil germinal center b cell

Tonsil

9-year-old stage 3-year-old stage 5-year-old stage 6-year-old stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

T cell Nasal mucosa goblet cell Ciliated cell Secretory cell Mast cell Cd8-positive, alpha-beta t cell Inflammatory macrophage Basal cell Ionocyte Plasmacytoid dendritic cell Enteroendocrine cell Cd8-positive, alpha-beta cytotoxic t cell Macrophage Squamous epithelial cell B cell Erythroblast Multiciliated epithelial cell Dendritic cell

Nasopharynx

Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Ninth decade stage

Covid-19 Long covid-19 Respiratory failure Normal

Female Male

Seq-well s3

Cell