Mus musculus

Macrophage Microglial cell

Brain

3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

Smart-seq2

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Lamp5 lhx6 neuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Choroid plexus epithelial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Fibroblast

Nucleus of dorsal thalamus

50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Mus musculus

Pituitary gland cell

Pituitary hormone deficiency, combined, 2 Normal

10x 3' v3

Microcebus murinus

T cell Neutrophil Granulosa cell Natural killer cell Endothelial cell of lymphatic vessel Non-myelinating schwann cell Reticular cell Endothelial cell Mature nk t cell Cd8-positive, alpha-beta t cell Pancreatic acinar cell Tendon cell Erythroid lineage cell Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Epithelial cell Adipocyte Macrophage Urothelial cell Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Mesothelial cell B cell Pericyte Monocyte Vascular associated smooth muscle cell Myofibroblast cell Basophil Conventional dendritic cell Fibroblast Dendritic cell

Brown adipose tissue Gonadal fat pad Mesenteric fat pad Subcutaneous adipose tissue Adipose tissue

Post-juvenile adult stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell B cell Pericyte Neuron Monocyte Caudal ganglionic eminence derived interneuron Astrocyte Fibroblast Mammillary body neuron

Median tuberal portion

50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

T cell Hepatocyte Endothelial cell Mature nk t cell Macrophage Malignant cell B cell Monocyte Fibroblast

Liver

55-year-old stage

Breast cancer

Female

10x 3' v2

Cell

Homo sapiens

Natural killer cell Erythroid progenitor cell Small pre-b-ii cell Gamma-delta t cell Pro-b cell Erythroid lineage cell Classical monocyte Pre-natural killer cell Plasmacytoid dendritic cell Precursor b cell Lymphoid lineage restricted progenitor cell Basophil mast progenitor cell Megakaryocyte progenitor cell Common dendritic progenitor Cd8-positive, alpha-beta memory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Unswitched memory b cell Cd16-positive, cd56-dim natural killer cell, human Myelocyte Plasma cell Late promyelocyte Hematopoietic multipotent progenitor cell Cd4-positive, alpha-beta memory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Early promyelocyte Immature b cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Central memory cd8-positive, alpha-beta t cell Naive b cell Conventional dendritic cell Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Bone marrow

26-year-old stage

Normal

Male

Bd rhapsody whole transcriptome analysis

Cell

Homo sapiens

Umbrella cell of urothelium Endothelial cell Leukocyte Smooth muscle cell Basal cell of urothelium Intermediate cell of urothelium Monocyte Fibroblast

Ureter

69-year-old stage

Normal

Male

10x 3' v3

Cell

Homo sapiens

Podocyte Parietal epithelial cell Endothelial cell Kidney loop of henle thin descending limb epithelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney connecting tubule epithelial cell Kidney loop of henle thick ascending limb epithelial cell Kidney loop of henle epithelial cell Mesangial cell Pericyte Kidney proximal convoluted tubule epithelial cell

Cortex of kidney

75-year-old stage

Normal

Male

Slide-seqv2

Drosophila melanogaster

Hemocyte Muscle cell

Male reproductive gland

Day 2 of adulthood

Normal

Male

10x 3' v3

Homo sapiens

Endothelial cell of lymphatic vessel Endothelial cell Endothelial cell of artery Schwann cell Smooth muscle cell Vein endothelial cell Vascular associated smooth muscle cell Fibroblast

Urinary bladder

21-year-old stage

Normal

Male

10x 3' v3

Cell Nucleus

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Microglial cell Thalamic excitatory neuron B cell Pericyte Neuron Monocyte Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Fibroblast

Centromedian nucleus of thalamus

50-year-old stage

Normal

Male

10x 3' v3

Nucleus