Homo sapiens

Blood vessel endothelial cell Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Microglial cell Astrocyte Gabaergic neuron

Brodmann (1909) area 9 Brodmann (1909) area 7 Brodmann (1909) area 17

66-year-old stage 75-year-old stage 91-year-old stage 89-year-old stage 93-year-old stage 87-year-old stage 71-year-old stage 85-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 68-year-old stage 92-year-old stage 111-year-old stage 82-year-old stage 80-year-old stage 57-year-old stage 81-year-old stage 97-year-old stage 58-year-old stage 67-year-old stage 62-year-old stage 86-year-old stage 70-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v3 Drop-seq 10x 3' v2

Nucleus

Homo sapiens

Granulocyte Natural killer cell Erythrocyte Gamma-delta t cell Mature nk t cell Hematopoietic precursor cell Platelet Cd4-positive helper t cell Classical monocyte Plasmacytoid dendritic cell Cd4-positive, alpha-beta cytotoxic t cell Cd8-positive, alpha-beta cytotoxic t cell Naive thymus-derived cd8-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Innate lymphoid cell Regulatory t cell Plasmablast Plasma cell B cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Central memory cd8-positive, alpha-beta t cell Naive b cell Conventional dendritic cell Dendritic cell Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Blood

66-year-old stage Pediatric stage 52-year-old stage 39-year-old stage 56-year-old stage 92-year-old stage 80-year-old stage 25-year-old stage Adult stage Late adult stage Postnatal stage 70-year-old stage Newborn stage (0-28 days) 76-year-old stage 73-year-old stage Child stage (1-4 yo) Juvenile stage (5-14 yo)

Covid-19 Normal Post-covid-19 disorder

Female Male

10x 5' v1

Cell

Homo sapiens

Cd8-positive, alpha-beta t cell Double-positive, alpha-beta thymocyte Cd4-positive, alpha-beta t cell Monocyte Double negative thymocyte

T cell

Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Ninth decade stage

B-cell non-hodgkin lymphoma

Female Male

10x 5' v1

Cell

Homo sapiens

Endothelial tip cell Blood vessel endothelial cell Endothelial cell of lymphatic vessel Fibroblast of mammary gland Perivascular cell Endothelial cell of artery Capillary endothelial cell Mural cell Vein endothelial cell

Breast

37-year-old stage 21-year-old stage 34-year-old stage 65-year-old stage 53-year-old stage 52-year-old stage 48-year-old stage 30-year-old stage 39-year-old stage 29-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 28-year-old stage 57-year-old stage 24-year-old stage 23-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 33-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 46-year-old stage 31-year-old stage 36-year-old stage 19-year-old stage 63-year-old stage 20-year-old stage 27-year-old stage 40-year-old stage

Normal

Female

10x 3' v3

Cell

Homo sapiens

Mature gamma-delta t cell Cd8aa(i) thymocyte Cd8-positive, alpha-beta memory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Mucosal invariant t cell Central memory cd8-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell

Blood

34-year-old stage 65-year-old stage 26-year-old stage 61-year-old stage 30-year-old stage 29-year-old stage 56-year-old stage 55-year-old stage 28-year-old stage 57-year-old stage 12-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 32-year-old stage 33-year-old stage 64-year-old stage 62-year-old stage 60-year-old stage 31-year-old stage 36-year-old stage 63-year-old stage 11-year-old stage 27-year-old stage

Cytomegalovirus infection Normal

Female Male

10x 3' v3

Cell

Mus musculus

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Smooth muscle cell Macrophage Microglial cell Leptomeningeal cell Pericyte Astrocyte Gabaergic neuron

Primary motor cortex

Prime adult stage

Normal

Female Male

Smart-seq v4 10x 3' v3 10x 3' v2

Nucleus Cell

Homo sapiens

T cell Endothelial cell Oligodendrocyte Myeloid cell Glial cell Pericyte Neuron

Temporal lobe Dorsal plus ventral thalamus Cerebral hemisphere Cerebellum

13-year-old stage 17-year-old stage 8-year-old stage 15-year-old stage 12-year-old stage 9-year-old stage 14-year-old stage 16-year-old stage 23-year-old stage 18-year-old stage 22-year-old stage 19-year-old stage 5-year-old stage 11-year-old stage 6-year-old stage 7-year-old stage 10-year-old stage 4-year-old stage

Pediatric high-grade glioma

Female Male

10x 3' v3

Nucleus

Homo sapiens

Off midget ganglion cell Retinal ganglion cell Off parasol ganglion cell On midget ganglion cell On parasol ganglion cell

Normal

10x 3' v3

Homo sapiens

Endothelial cell of hepatic sinusoid T cell Blood vessel endothelial cell Hepatocyte Mature nk t cell Blood vessel smooth muscle cell Hepatic stellate cell Adipocyte Macrophage Endothelial stalk cell Plasma cell Malignant cell Cell of skeletal muscle B cell Neuron Monocyte Fibroblast Chondrocyte

Breast Axilla Liver Bone spine Skin epidermis Brain Chest wall

37-year-old stage 42-year-old stage 43-year-old stage 54-year-old stage 39-year-old stage 44-year-old stage 50-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 49-year-old stage 35-year-old stage 62-year-old stage 41-year-old stage 46-year-old stage 60-year-old stage 31-year-old stage 63-year-old stage 27-year-old stage 40-year-old stage

Breast cancer

Female

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell T cell Cd1c-positive myeloid dendritic cell Mature gamma-delta t cell Natural killer cell Erythrocyte Platelet Cd141-positive myeloid dendritic cell Effector memory cd4-positive, alpha-beta t cell Intermediate monocyte Cd8aa(i) thymocyte Plasmacytoid dendritic cell Basophil mast progenitor cell Cd8-positive, alpha-beta memory t cell Be cell Memory regulatory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Axl+ dendritic cell, human Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Common myeloid progenitor Plasma cell Naive regulatory t cell Memory ccr4-positive regulatory t cell Cd14-low, cd16-positive monocyte Cd4-positive, alpha-beta memory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Common lymphoid progenitor Mucosal invariant t cell Cd8-positive, alpha-beta regulatory t cell Transitional stage b cell Cd14-positive, cd16-negative classical monocyte Central memory cd8-positive, alpha-beta t cell Naive b cell Double negative thymocyte Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

37-year-old stage 75-year-old stage 34-year-old stage 71-year-old stage 61-year-old stage 54-year-old stage 68-year-old stage 44-year-old stage 55-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 74-year-old stage 24-year-old stage 23-year-old stage 59-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage 76-year-old stage

Cytomegalovirus infection Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Endocardial cell Schwann cell Smooth muscle cell Cardiac blood vessel endothelial cell Lymphocyte Adipocyte Macrophage Mesothelial cell Cardiac muscle cell Pericyte Fibroblast

Right atrium auricular region

Sixth decade stage Fifth decade stage Seventh decade stage Eighth decade stage Ninth decade stage

Normal Heart valve disorder Myocardial infarction Coronary artery disorder

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Endothelial cell Mast cell Epithelial cell Plasmacytoid dendritic cell Megakaryocyte Malignant cell B cell Fibroblast Mononuclear phagocyte

Lung Colorectum Breast Liver Ovary Skin epidermis Blood Uvea

66-year-old stage 69-year-old stage 37-year-old stage 75-year-old stage 65-year-old stage 42-year-old stage 43-year-old stage Sixth decade stage 71-year-old stage 85-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 68-year-old stage 44-year-old stage 38-year-old stage Fifth decade stage 80-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage Seventh decade stage 58-year-old stage 25-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 86-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 78-year-old stage 63-year-old stage Eighth decade stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage 83-year-old stage Ninth decade stage 27-year-old stage

Melanoma Ovarian cancer Lung adenocarcinoma Pleomorphic carcinoma Colorectal adenocarcinoma Invasive ductal breast carcinoma Rectosigmoid carcinoma Breast cancer Liver cancer Breast apocrine carcinoma Metaplastic breast carcinoma Squamous cell carcinoma Cecum adenocarcinoma Ovarian clear cell adenocarcinoma Normal Serous adenocarcinoma Lung cancer Colon adenocarcinoma Uveal melanoma Large cell carcinoma

Female Male

10x 3' v1 10x 5' v2 Indrop Smart-seq2 10x 3' v3 10x 3' v2

Cell