Homo sapiens

Natural killer cell Naive b cell Cd8-positive, alpha-beta t cell Regulatory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Plasmablast Cd4-positive, alpha-beta memory t cell Cd16-negative, cd56-bright natural killer cell, human Lymphocyte Plasma cell Mucosal invariant t cell Mature nk t cell, human Cd16-positive, cd56-dim natural killer cell, human

Blood

26-year-old stage 50-year-old stage 52-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage 37-year-old stage 29-year-old stage 58-year-old stage 24-year-old stage 22-year-old stage 34-year-old stage 31-year-old stage 42-year-old stage 49-year-old stage 54-year-old stage 25-year-old stage 57-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 55-year-old stage 44-year-old stage 47-year-old stage 20-year-old stage 36-year-old stage 32-year-old stage 45-year-old stage 40-year-old stage 60-year-old stage 19-year-old stage 39-year-old stage 28-year-old stage 18-year-old stage 38-year-old stage 23-year-old stage 30-year-old stage 27-year-old stage 48-year-old stage 51-year-old stage 33-year-old stage

Normal

Female Male

10x 5' v2

Cell

Mus musculus

Glutamatergic neuron

Caudate-putamen Anterior olfactory nucleus Hippocampal field Olfactory cortex Orbitofrontal cortex Pallidum Primary motor cortex Anterior cerebral artery Lateral septal complex Primary auditory cortex Piriform cortex Primary somatosensory cortex Nucleus accumbens Secondary somatosensory cortex Cerebral cortex Dentate gyrus of hippocampal formation

Prime adult stage

Normal

Male

Scatac-seq

Nucleus

Mus musculus

Oligodendrocyte Erythrocyte Fibroblast Tanycyte Mural cell Hypendymal cell Ependymal cell Oligodendrocyte precursor cell Microglial cell Pituitary gland cell Neuron Endothelial cell Astrocyte

Hypothalamus

1-week-old stage 4-week-old stage 6-week-old stage 26-day-old stage 8-week-old stage 9-week-old stage Juvenile stage 2-week-old stage 23-day-old stage 2-month-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 3' v1 Drop-seq

Nucleus Cell

Mus musculus

Oligodendrocyte Medium spiny neuron Pericyte Vascular leptomeningeal cell Inhibitory interneuron Macrophage T cell Oligodendrocyte precursor cell Microglial cell Neuron Endothelial cell Cell Astrocyte

Brain ventricle Corpus callosum Cortical layer v Olfactory region Pia mater Cortical layer vi Striatum Cortical layer ii/iii

4-week-old stage 20-month-old stage and over 24-week-old stage

Normal

Female

Merfish

Mus musculus

Oligodendrocyte Medium spiny neuron Pericyte Vascular leptomeningeal cell Inhibitory interneuron Macrophage T cell Oligodendrocyte precursor cell Microglial cell Neuron Endothelial cell Cell Astrocyte

Brain ventricle Corpus callosum Cortical layer v Olfactory region Pia mater Cortical layer vi Striatum Cortical layer ii/iii

4-week-old stage 20-month-old stage and over 24-week-old stage

Normal

Female

Merfish

Homo sapiens

Oligodendrocyte Neuroblast (sensu vertebrata) Neuron Glioblast Radial glial cell Neuroblast (sensu nematoda and protostomia)

Hippocampal formation Choroid plexus epithelium Upper layers of the cortex Caudate-putamen Lower layers of the cortex Entorhinal cortex Occipital cortex Cortex Forebrain Telencephalon Frontal cortex Striatum

15th week post-fertilization stage 11th week post-fertilization stage 14th week post-fertilization stage 9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 20

Normal

10x 3' v2 10x 3' v3

Cell

Homo sapiens

On parasol ganglion cell Off parasol ganglion cell On midget ganglion cell Retinal ganglion cell Off midget ganglion cell

Macula lutea proper Peripheral region of retina Macula lutea Fovea centralis

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 90 year-old and over stage 15-year-old stage 58-year-old stage 24-year-old stage 73-year-old stage Late adult stage 75-year-old stage 3-year-old stage 84-year-old stage 34-year-old stage 86-year-old stage 25-year-old stage 66-year-old stage 11-year-old stage 74-year-old stage Eighth decade stage 21-year-old stage 83-year-old stage 53-year-old stage 46-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 32-year-old stage 60-79 year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 88-year-old stage 60-year-old stage 62-year-old stage 16-year-old stage 10-year-old stage 18-year-old stage Prime adult stage 30-year-old stage 72-year-old stage 27-year-old stage 17-year-old stage 71-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Schwann cell Neuroblast (sensu vertebrata) Fibroblast Cortical cell of adrenal gland Macrophage Dendritic cell T cell Kidney cell Hepatocyte Endothelial cell B cell

Liver Lymph node Neck Chest Cervical lymph node Abdomen Adrenal gland

7-year-old stage 16-month-old stage 5-year-old stage 15-month-old stage 3-year-old stage 12-month-old stage 12-year-old stage 2-year-old stage 4-year-old stage 6-month-old stage 20-month-old stage 13-year-old stage 21-month-old stage 18-month-old stage

Neuroblastoma

Female Male

10x 3' v3

Nucleus

Macaca mulatta

Gabaergic neuron

Hippocampal formation Cerebrocerebellum Medial dorsal nucleus of thalamus Medulla oblongata Ventral lateral nucleus of thalamus Inferior parietal cortex Cerebellar vermis Brodmann (1909) area 19 Entorhinal cortex Anterior cingulate cortex Primary motor cortex Inferior temporal gyrus Primary visual cortex Corpus callosum Lateral geniculate body Head of caudate nucleus Superior temporal sulcus Primary auditory cortex Primary somatosensory cortex Dorsolateral prefrontal cortex Amygdala Perirhinal cortex Prefrontal cortex Nucleus accumbens Midbrain Superior parietal cortex Pons

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Macaca mulatta

Cerebellar neuron

Hippocampal formation Cerebrocerebellum Medial dorsal nucleus of thalamus Medulla oblongata Ventral lateral nucleus of thalamus Inferior parietal cortex Cerebellar vermis Brodmann (1909) area 19 Entorhinal cortex Anterior cingulate cortex Primary motor cortex Inferior temporal gyrus Primary visual cortex Corpus callosum Lateral geniculate body Head of caudate nucleus Superior temporal sulcus Primary auditory cortex Primary somatosensory cortex Dorsolateral prefrontal cortex Amygdala Perirhinal cortex Prefrontal cortex Nucleus accumbens Midbrain Superior parietal cortex Pons

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Mature nk t cell Natural killer cell Mature conventional dendritic cell Schwann cell Cd8-positive, alpha-beta t cell Colon endothelial cell Endothelial cell of lymphatic vessel Capillary endothelial cell Mast cell Fibroblast Monocyte Igg plasma cell Pericyte Group 3 innate lymphoid cell T-helper 17 cell Activated cd4-positive, alpha-beta t cell Enteroendocrine cell Macrophage Gamma-delta t cell Intestinal epithelial cell Dendritic cell T cell Cd8-positive, alpha-beta memory t cell Mature b cell Endothelial cell of venule Tuft cell of colon Granulocyte Endothelial tip cell Colonocyte Conventional dendritic cell Germinal center b cell Enterocyte Iga plasma cell Stem cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Glandular secretory epithelial cell Goblet cell Myofibroblast cell Plasmacytoid dendritic cell Cd4-positive, alpha-beta t cell T follicular helper cell Smooth muscle cell Endothelial cell of artery Effector cd8-positive, alpha-beta t cell Colon goblet cell

Colorectum

64-year-old stage 91-year-old stage 50-year-old stage 52-year-old stage 82-year-old stage 35-year-old stage 58-year-old stage 73-year-old stage 84-year-old stage 42-year-old stage 49-year-old stage 59-year-old stage 61-year-old stage 57-year-old stage 89-year-old stage 53-year-old stage 56-year-old stage 55-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 36-year-old stage 45-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 90-year-old stage 60-year-old stage 62-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage

Normal Colon adenocarcinoma

Female Male

10x 3' v2 10x 3' v3

Cell

Mus musculus

Mature nk t cell Erythroblast Oligodendrocyte Professional antigen presenting cell Endocardial cell Non-classical monocyte Bladder urothelial cell Kidney capillary endothelial cell Natural killer cell Epithelial cell of thymus Interneuron Schwann cell Erythrocyte Neutrophil Naive b cell Classical monocyte Smooth muscle cell of trachea Cd8-positive, alpha-beta t cell Late pro-b cell Medium spiny neuron Pulmonary interstitial fibroblast Bladder cell Endothelial cell of lymphatic vessel Cell of skeletal muscle Pulmonary alveolar type 1 cell Regulatory t cell Granulocyte monocyte progenitor cell Dn4 thymocyte Kidney interstitial fibroblast Pancreatic a cell Neuroepithelial stem cell Type b pancreatic cell Mast cell Neural stem cell Aortic endothelial cell Leukocyte Smooth muscle cell of the pulmonary artery Fibroblast Cardiac neuron Promonocyte Monocyte Blood cell Erythroid progenitor cell, mammalian Mesangial cell Pericyte Megakaryocyte-erythroid progenitor cell Kidney proximal convoluted tubule epithelial cell Club cell Enterocyte of epithelium of large intestine Myeloid leukocyte Basophil Large intestine goblet cell Lymphoid lineage restricted progenitor cell Immature nk t cell Tuft cell Epithelial cell of proximal tubule Respiratory basal cell Precursor b cell Enteroendocrine cell Endothelial cell of hepatic sinusoid Double negative thymocyte Kidney collecting duct principal cell Mesenchymal stem cell Macrophage Multiciliated columnar cell of tracheobronchial tree Pancreatic d cell Dendritic cell Basal epithelial cell of tracheobronchial tree T cell Kidney proximal straight tubule epithelial cell Hematopoietic precursor cell Kidney loop of henle thick ascending limb epithelial cell Cardiac valve cell Kidney cell Vein endothelial cell Naive t cell Skeletal muscle satellite cell Epidermal cell Plasmatocyte Myeloid cell Granulocytopoietic cell Pancreatic ductal cell Kidney distal convoluted tubule epithelial cell Kidney loop of henle ascending limb epithelial cell Granulocyte Kidney cortex artery cell Epithelial cell Ependymal cell Hepatocyte Intestinal crypt stem cell Regular ventricular cardiac myocyte Endothelial cell of coronary artery Mature alpha-beta t cell Lymphocyte Hepatic stellate cell Mesenchymal stem cell of adipose tissue Macrophage dendritic cell progenitor Oligodendrocyte precursor cell Langerhans cell Dn3 thymocyte Basal cell of epidermis Kupffer cell Lung macrophage Regular atrial cardiac myocyte Pulmonary alveolar type 2 cell Fibroblast of cardiac tissue Plasma cell Microglial cell Stem cell of epidermis Proerythroblast Stromal cell Alveolar macrophage Pancreatic stellate cell Bronchial smooth muscle cell Mesenchymal cell Circulating fibrocyte Kidney collecting duct epithelial cell Pulmonary neuroendocrine cell Neuron Plasmacytoid dendritic cell Myeloid dendritic cell Cardiac muscle cell Pancreatic pp cell Fibroblast of lung Endothelial cell Secretory cell Duct epithelial cell Neuroendocrine cell Chondrocyte Immature t cell Cd4-positive, alpha-beta t cell Luminal epithelial cell of mammary gland Smooth muscle cell Epithelial cell of large intestine Fenestrated endothelial cell Brain pericyte Immature b cell Intermediate monocyte Pancreatic acinar cell Tuft cell of large intestine B cell Keratinocyte Adventitial cell Bergmann glial cell Mucus secreting cell Keratinocyte stem cell Hematopoietic stem cell Basal cell Astrocyte Thymocyte Early pro-b cell

Liver Diaphragm Limb muscle Kidney Bone marrow Trachea Large intestine Pancreas Gonadal fat pad Heart Tongue Spleen Mesenteric fat pad Mammary gland Skin of body Adipose tissue Brain Thymus Lung Bladder lumen Brown adipose tissue Subcutaneous adipose tissue Aorta

4-week-old stage 3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

10x 3' v2 Smart-seq2

Cell