Homo sapiens

Astrocyte Gabaergic neuron Oligodendrocyte precursor cell Oligodendrocyte Blood vessel endothelial cell Glutamatergic neuron Microglial cell

Brodmann (1909) area 17 Brodmann (1909) area 7 Brodmann (1909) area 9

62-year-old stage 73-year-old stage 83-year-old stage 85-year-old stage 81-year-old stage 61-year-old stage 57-year-old stage 82-year-old stage 111-year-old stage 52-year-old stage 86-year-old stage 70-year-old stage 58-year-old stage 75-year-old stage 79-year-old stage 89-year-old stage 68-year-old stage 66-year-old stage 93-year-old stage 76-year-old stage 88-year-old stage 87-year-old stage 97-year-old stage 80-year-old stage 91-year-old stage 92-year-old stage 67-year-old stage 71-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v3 Drop-seq 10x 3' v2

Nucleus

Homo sapiens

Innate lymphoid cell Plasmablast Class switched memory b cell Mucosal invariant t cell Effector memory cd8-positive, alpha-beta t cell Granulocyte Cd4-positive, alpha-beta cytotoxic t cell Hematopoietic precursor cell Plasma cell Dendritic cell B cell Gamma-delta t cell Regulatory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Non-classical monocyte Plasmacytoid dendritic cell Cd4-positive helper t cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Cd16-negative, cd56-bright natural killer cell, human Central memory cd8-positive, alpha-beta t cell Natural killer cell Platelet Erythrocyte Conventional dendritic cell Mature nk t cell Classical monocyte Naive b cell Cd8-positive, alpha-beta cytotoxic t cell

Blood

Adult stage 39-year-old stage 73-year-old stage Postnatal stage Juvenile stage (5-14 yo) Newborn stage (0-28 days) 52-year-old stage 70-year-old stage 66-year-old stage Late adult stage Child stage (1-4 yo) 76-year-old stage 80-year-old stage 25-year-old stage 56-year-old stage Pediatric stage 92-year-old stage

Post-covid-19 disorder Covid-19 Normal

Female Male

10x 5' v1

Cell

Homo sapiens

Double negative thymocyte Cd8-positive, alpha-beta t cell Monocyte Cd4-positive, alpha-beta t cell Double-positive, alpha-beta thymocyte

T cell

Ninth decade stage Third decade stage Sixth decade stage Fourth decade stage Eighth decade stage Fifth decade stage Seventh decade stage

B-cell non-hodgkin lymphoma

Female Male

10x 5' v1

Cell

Homo sapiens

Perivascular cell Vein endothelial cell Endothelial tip cell Capillary endothelial cell Endothelial cell of lymphatic vessel Fibroblast of mammary gland Endothelial cell of artery

Breast

35-year-old stage 39-year-old stage 62-year-old stage 27-year-old stage 53-year-old stage 19-year-old stage 21-year-old stage 57-year-old stage 36-year-old stage 52-year-old stage 48-year-old stage 40-year-old stage 38-year-old stage 45-year-old stage 41-year-old stage 59-year-old stage 30-year-old stage 55-year-old stage 23-year-old stage 58-year-old stage 29-year-old stage 33-year-old stage 28-year-old stage 31-year-old stage 63-year-old stage 25-year-old stage 56-year-old stage 37-year-old stage 46-year-old stage 24-year-old stage 20-year-old stage 65-year-old stage 34-year-old stage

Normal

Female

10x 3' v3

Cell

Homo sapiens

Mucosal invariant t cell Effector memory cd8-positive, alpha-beta t cell Mature gamma-delta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Central memory cd8-positive, alpha-beta t cell Cd8-positive, alpha-beta memory t cell Cd8aa(i) thymocyte

Blood

35-year-old stage 62-year-old stage 27-year-old stage 26-year-old stage 61-year-old stage 57-year-old stage 36-year-old stage 12-year-old stage 59-year-old stage 30-year-old stage 55-year-old stage 58-year-old stage 64-year-old stage 29-year-old stage 11-year-old stage 33-year-old stage 32-year-old stage 28-year-old stage 31-year-old stage 63-year-old stage 60-year-old stage 25-year-old stage 56-year-old stage 65-year-old stage 34-year-old stage

Cytomegalovirus infection Normal

Female Male

10x 3' v3

Cell

Mus musculus

Astrocyte Leptomeningeal cell Gabaergic neuron Smooth muscle cell Oligodendrocyte precursor cell Oligodendrocyte Pericyte Glutamatergic neuron Macrophage Microglial cell Endothelial cell

Primary motor cortex

Prime adult stage

Normal

Female Male

Smart-seq v4 10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Fibroblast Malignant cell Plasma cell B cell Blood vessel endothelial cell Chondrocyte Hepatocyte Adipocyte Cell of skeletal muscle Blood vessel smooth muscle cell Endothelial stalk cell Endothelial cell of hepatic sinusoid Macrophage Hepatic stellate cell Monocyte Mature nk t cell T cell Neuron

Liver Brain Skin epidermis Bone spine Axilla Breast Chest wall

54-year-old stage 35-year-old stage 39-year-old stage 62-year-old stage 27-year-old stage 57-year-old stage 49-year-old stage 42-year-old stage 40-year-old stage 41-year-old stage 50-year-old stage 51-year-old stage 28-year-old stage 31-year-old stage 63-year-old stage 60-year-old stage 37-year-old stage 46-year-old stage 43-year-old stage 44-year-old stage

Breast cancer

Female

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Fibroblast Schwann cell Endocardial cell Smooth muscle cell Cardiac muscle cell Pericyte Lymphocyte Adipocyte Macrophage Cardiac blood vessel endothelial cell Mesothelial cell

Right atrium auricular region

Ninth decade stage Sixth decade stage Eighth decade stage Fifth decade stage Seventh decade stage

Myocardial infarction Coronary artery disorder Heart valve disorder Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Fibroblast Mast cell Neutrophil Epithelial cell Mononuclear phagocyte Malignant cell B cell Megakaryocyte Plasmacytoid dendritic cell T cell Endothelial cell

Lung Liver Blood Colorectum Uvea Skin epidermis Ovary Breast

54-year-old stage 62-year-old stage 27-year-old stage 78-year-old stage 73-year-old stage 74-year-old stage 72-year-old stage 53-year-old stage Ninth decade stage 83-year-old stage 85-year-old stage 81-year-old stage 61-year-old stage 57-year-old stage Sixth decade stage 42-year-old stage 52-year-old stage 86-year-old stage 70-year-old stage 38-year-old stage 45-year-old stage 41-year-old stage Eighth decade stage 58-year-old stage 75-year-old stage 51-year-old stage 79-year-old stage 64-year-old stage 68-year-old stage 66-year-old stage 77-year-old stage 69-year-old stage 76-year-old stage Fifth decade stage 63-year-old stage 60-year-old stage 80-year-old stage 25-year-old stage 37-year-old stage 46-year-old stage 67-year-old stage 43-year-old stage 65-year-old stage 71-year-old stage Seventh decade stage 44-year-old stage 47-year-old stage

Breast apocrine carcinoma Melanoma Rectosigmoid carcinoma Colorectal adenocarcinoma Ovarian cancer Large cell carcinoma Squamous cell carcinoma Invasive ductal breast carcinoma Liver cancer Serous adenocarcinoma Lung cancer Pleomorphic carcinoma Breast cancer Ovarian clear cell adenocarcinoma Cecum adenocarcinoma Metaplastic breast carcinoma Colon adenocarcinoma Uveal melanoma Normal Lung adenocarcinoma

Female Male

10x 3' v3 10x 3' v1 Indrop 10x 5' v2 Smart-seq2 10x 3' v2

Cell

Homo sapiens

Double negative thymocyte Gamma-delta t cell Regulatory t cell Cd8-positive, alpha-beta regulatory t cell Cd8-positive, alpha-beta t cell Early t lineage precursor Natural killer cell Immature alpha-beta t cell Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta t cell T cell Double-positive, alpha-beta thymocyte

Thymus

14th week post-fertilization stage 14-month-old stage Newborn stage (0-28 days) 2-month-old stage 3-month-old stage 2-year-old stage 20th week post-fertilization stage 10-month-old stage 15th week post-fertilization stage 13th week post-fertilization stage 5-month-old stage 12th week post-fertilization stage 24th week post-fertilization stage 18th week post-fertilization stage 6-month-old stage 17th week post-fertilization stage

Normal

Female Male

10x 3' v3 10x 5' v2 10x 5' v1 10x 3' v2

Cell

Mus musculus

Glutamatergic neuron

Primary motor cortex Dentate gyrus of hippocampal formation Nucleus accumbens Primary somatosensory cortex Lateral septal complex Cerebral cortex Piriform cortex Anterior olfactory nucleus Pallidum Anterior cerebral artery Primary auditory cortex Olfactory cortex Secondary somatosensory cortex Caudate-putamen Hippocampal field Orbitofrontal cortex

Prime adult stage

Normal

Male

Scatac-seq

Nucleus

Mus musculus

Fibroblast Pituitary gland cell Astrocyte Mural cell Oligodendrocyte precursor cell Oligodendrocyte Hypendymal cell Ependymal cell Tanycyte Erythrocyte Microglial cell Neuron Endothelial cell

Hypothalamus

2-month-old stage Juvenile stage 6-week-old stage 8-week-old stage 4-week-old stage 1-week-old stage 9-week-old stage 26-day-old stage 2-week-old stage 23-day-old stage

Normal

Female Male

10x 3' v3 Drop-seq 10x 3' v1 10x 3' v2

Nucleus Cell