Homo sapiens

Natural killer cell Schwann cell Erythrocyte Neutrophil Naive b cell Cd8-positive, alpha-beta t cell Late pro-b cell Endothelial cell of lymphatic vessel Regulatory t cell Granulocyte monocyte progenitor cell Ciliated epithelial cell Capillary endothelial cell Mast cell Fibroblast Promonocyte Monocyte Cortical thymic epithelial cell Pericyte Common myeloid progenitor Memory b cell Precursor b cell Double negative thymocyte Macrophage Gamma-delta t cell T cell Mesothelial cell Cd8-positive, alpha-beta memory t cell Cd8-positive, alpha-beta regulatory t cell Vein endothelial cell Large pre-b-ii cell Corticomedullary thymic epithelial cell Myo-medullary thymic epithelial cell Small pre-b-ii cell Pro-b cell Conventional dendritic cell Plasma cell Double-positive, alpha-beta thymocyte Medullary thymic epithelial cell type 3 Early t lineage precursor Neuro-medullary thymic epithelial cell Immature alpha-beta t cell Medullary thymic epithelial cell type 2 Plasmacytoid dendritic cell Thymic fibroblast type 2 Medullary thymic epithelial cell type 1 Cd4-positive, alpha-beta t cell Myelocyte Smooth muscle cell Endothelial cell of artery B cell Thymic fibroblast type 1

Thymus

24th week post-fertilization stage 15th week post-fertilization stage 2-month-old stage 14th week post-fertilization stage 13th week post-fertilization stage 2-year-old stage 14-month-old stage 10-month-old stage 12th week post-fertilization stage 5-month-old stage 6-month-old stage Newborn stage (0-28 days) 17th week post-fertilization stage 3-month-old stage 18th week post-fertilization stage 20th week post-fertilization stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' v2 10x 5' v1

Cell

Callithrix jacchus

Glutamatergic neuron

Brodmann (1909) area 23 Brodmann (1909) area 25 Dorsolateral prefrontal cortex Parietal cortex Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Secondary visual cortex Temporal cortex Temporal lobe

Prime adult stage Late adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Natural killer cell Endothelial cell of arteriole Alveolar type 1 fibroblast cell Classical monocyte Pulmonary alveolar type 1 cell Mast cell Helper t cell Monocyte Pericyte Hematopoietic cell Epithelial cell of lung Pulmonary capillary endothelial cell Ciliated cell Macrophage Myeloid dendritic cell, human Adventitial fibroblast Cd8-positive, alpha-beta cytotoxic t cell Vein endothelial cell of respiratory system Lung interstitial macrophage Conventional dendritic cell Pulmonary alveolar type 2 cell Plasma cell Alveolar macrophage Granzyme k-associated cd8 t cell Myofibroblast cell Pulmonary neuroendocrine cell Plasmacytoid dendritic cell Mesothelial cell of pleura Smooth muscle cell Endothelial cell of respiratory system lymphatic vessel B cell Basal cell Lung secretory cell

Lung

64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage 63-year-old stage 15-year-old stage 29-year-old stage 58-year-old stage 73-year-old stage 34-year-old stage 31-year-old stage 49-year-old stage 59-year-old stage 54-year-old stage 25-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 47-year-old stage 36-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 60-year-old stage 62-year-old stage 19-year-old stage 38-year-old stage 30-year-old stage 72-year-old stage 27-year-old stage 17-year-old stage 71-year-old stage

Normal Hypersensitivity pneumonitis Anthracosis Pulmonary sarcoidosis Non-specific interstitial pneumonia Lymphoid interstitial pneumonia Interstitial lung disease

Female Male

10x 5' v2 10x 5' v1

Cell

Homo sapiens

Dendritic cell, human Natural killer cell Naive b cell Cd8-positive, alpha-beta t cell Cd14-positive monocyte Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Lymphocyte Platelet Plasma cell Plasmacytoid dendritic cell Cd14-positive, cd16-positive monocyte Cd4-positive, alpha-beta t cell

Blood

26-year-old stage 50-year-old stage 52-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage 37-year-old stage 29-year-old stage 58-year-old stage 24-year-old stage 22-year-old stage 34-year-old stage 31-year-old stage 42-year-old stage 49-year-old stage 54-year-old stage 25-year-old stage 57-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 55-year-old stage 44-year-old stage 47-year-old stage 20-year-old stage 36-year-old stage 32-year-old stage 45-year-old stage 40-year-old stage 60-year-old stage 19-year-old stage 39-year-old stage 28-year-old stage 18-year-old stage 38-year-old stage 23-year-old stage 30-year-old stage 27-year-old stage 48-year-old stage 51-year-old stage 33-year-old stage

Normal

Female Male

10x 5' v2

Cell

Homo sapiens

Cerebral cortex gabaergic interneuron Progenitor cell Cajal-retzius cell Cerebral cortex endothelial cell Forebrain radial glial cell Blood vessel endothelial cell Oligodendrocyte precursor cell Microglial cell Glutamatergic neuron

Parietal cortex Prefrontal cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Temporal cortex

22nd week post-fertilization stage 14th week post-fertilization stage 19th week post-fertilization stage 25th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage 18th week post-fertilization stage 20th week post-fertilization stage

Normal

10x 3' v2

Cell

Homo sapiens

Naive b cell Transitional stage b cell Memory b cell Be cell Plasma cell

Blood

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 84-year-old stage 42-year-old stage 49-year-old stage 86-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 83-year-old stage 89-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 45-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 88-year-old stage 87-year-old stage 60-year-old stage 62-year-old stage 79-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage

Normal Cytomegalovirus infection

Female Male

10x gene expression flex

Cell

Homo sapiens

Intratelencephalic-projecting glutamatergic cortical neuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior olivary complex Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Midbrain nucleus Midbrain tectum Middle temporal gyrus Nucleus accumbens Nucleus of dorsal thalamus Nucleus of medulla oblongata Parabrachial nucleus Perirhinal cortex Piriform cortex Pontine nuclear group Pontine reticular formation Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Septal nuclear complex Spinal cord Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Ventral anterior nucleus of thalamus

50-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte Fibroblast Mural cell Ependymal cell Microglial cell Neuron Endothelial cell Astrocyte

Hypothalamus

91-year-old stage 50-year-old stage 63-year-old stage 29-year-old stage 42-year-old stage 59-year-old stage 92-year-old stage 83-year-old stage 94-year-old stage 67-year-old stage 88-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte Pericyte Endothelial cell of vascular tree Inhibitory interneuron T cell Oligodendrocyte precursor cell Microglial cell Glutamatergic neuron Astrocyte

Brodmann (1909) area 4 Insular cortex Primary visual cortex

80 year-old and over stage 64-year-old stage 58-year-old stage 59-year-old stage 61-year-old stage 57-year-old stage 56-year-old stage 60-79 year-old stage 60-year-old stage

Progressive supranuclear palsy Normal Pick disease Alzheimer disease

Female Male

10x 3' v2 10x 3' v3

Nucleus

Homo sapiens

Mature nk t cell Inflammatory macrophage Megakaryocyte Natural killer cell Gip cell Interneuron Activated cd8-positive, alpha-beta t cell Erythrocyte Neutrophil Naive b cell Cd8-positive, alpha-beta t cell Type l enteroendocrine cell Follicular dendritic cell Endothelial cell of lymphatic vessel Interstitial cell of cajal Regulatory t cell Neuroblast (sensu vertebrata) Enteric smooth muscle cell Primary sensory neuron (sensu teleostei) Nkp44-negative group 3 innate lymphoid cell, human Capillary endothelial cell Type b pancreatic cell Mast cell Intestine goblet cell Progenitor cell Monocyte Igg plasma cell Nkp44-positive group 3 innate lymphoid cell, human Pericyte Mesodermal cell Group 3 innate lymphoid cell Mesenchymal lymphangioblast Motor neuron Germ cell T-helper 17 cell Memory b cell Precursor b cell Activated cd4-positive, alpha-beta t cell Enteroendocrine cell Group 2 innate lymphoid cell Macrophage Gamma-delta t cell Type i enteroendocrine cell T cell Colon epithelial cell Mesothelial cell Cd8-positive, alpha-beta memory t cell Cd34-positive, cd56-positive, cd117-positive common innate lymphoid precursor, human Glial cell Vein endothelial cell Migratory enteric neural crest cell Type n enteroendocrine cell Epithelial cell Colonocyte Oligodendrocyte precursor cell Pro-b cell Common lymphoid progenitor Conventional dendritic cell Germinal center b cell Plasma cell T-helper 1 cell Type d enteroendocrine cell Stromal cell Iga plasma cell Stem cell Transit amplifying cell Mucosal invariant t cell Type ec enteroendocrine cell Myofibroblast cell M cell of gut Plasmacytoid dendritic cell Stromal cell of lamina propria of small intestine Cd4-positive, alpha-beta t cell T follicular helper cell Endothelial cell of artery Immature b cell B cell Igm plasma cell Inhibitory motor neuron Intestinal tuft cell Reticular cell Progenitor cell of endocrine pancreas

Ascending colon Caecum Colon Descending colon Duodenum Ileum Jejunum Large intestine Lymph node Mesenteric lymph node Rectum Sigmoid colon Small intestine Transverse colon Vermiform appendix

6-year-old stage 15th week post-fertilization stage Fifth decade stage 14-year-old stage 11th week post-fertilization stage 9-year-old stage Carnegie stage 23 12-year-old stage 11-year-old stage Eighth decade stage Carnegie stage 22 Seventh decade stage 12th week post-fertilization stage 10th week post-fertilization stage 4-year-old stage 17th week post-fertilization stage 16th week post-fertilization stage 13-year-old stage Sixth decade stage 10-year-old stage Carnegie stage 19 Carnegie stage 16 Carnegie stage 17 Carnegie stage 20 Third decade stage

Normal Crohn disease

Female Male

10x 3' v2 10x 5' v2

Cell

Homo sapiens

Abnormal cell Fibroblast Myeloid leukocyte T cell Perivascular cell Endothelial cell Lymphocyte of b lineage

Breast

Late adult stage Young adult stage Middle aged stage

Triple-negative breast carcinoma

Female

10x 3' v2 10x 3' v3

Cell

Homo sapiens

Oligodendrocyte Blood vessel endothelial cell Oligodendrocyte precursor cell Microglial cell Gabaergic neuron Glutamatergic neuron Astrocyte

Brodmann (1909) area 17 Brodmann (1909) area 7 Brodmann (1909) area 9

85-year-old stage 80-year-old stage 91-year-old stage 52-year-old stage 68-year-old stage 82-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 93-year-old stage 86-year-old stage 92-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 83-year-old stage 89-year-old stage 97-year-old stage 111-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 67-year-old stage 88-year-old stage 87-year-old stage 62-year-old stage 79-year-old stage 71-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v2 10x 3' v3 Drop-seq

Nucleus