Homo sapiens

Mature nk t cell Epithelial cell of thymus Cd8-positive, alpha-beta t cell Regulatory t cell Mast cell Fibroblast Monocyte Malignant cell Activated cd8-positive, alpha-beta t cell, human Naive thymus-derived cd8-positive, alpha-beta t cell T-helper 17 cell Macrophage Dendritic cell Hematopoietic multipotent progenitor cell T cell Plasmacytoid dendritic cell, human Naive t cell Myeloid cell Lymphocyte Plasma cell Central memory cd8-positive, alpha-beta t cell Microglial cell Myofibroblast cell Cd8-positive, cd28-negative, alpha-beta regulatory t cell Endothelial cell Cd4-positive, alpha-beta t cell T follicular helper cell Effector cd8-positive, alpha-beta t cell B cell Melanocyte

Liver Kidney Breast Skin of knee Skin of forehead Skin of neck Skin of calf Skin of scalp Skin of body Nose skin Brain Skin of external ear Skin of cheek Arm skin

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 43-year-old stage 41-year-old stage Fifth decade stage 63-year-old stage 37-year-old stage 58-year-old stage 73-year-old stage Adult stage Late adult stage 86-year-old stage 54-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage Eighth decade stage 83-year-old stage Fourth decade stage 77-year-old stage Seventh decade stage 47-year-old stage 60-79 year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage Postnatal stage 60-year-old stage 62-year-old stage Sixth decade stage Prime adult stage 79-year-old stage 72-year-old stage 71-year-old stage Middle aged stage

Estrogen-receptor positive breast cancer Squamous cell carcinoma Triple-negative breast carcinoma Metastatic melanoma Hepatocellular carcinoma Her2 positive breast carcinoma Melanoma Nonpapillary renal cell carcinoma Basal cell carcinoma Intrahepatic cholangiocarcinoma

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling Smart-seq2

Cell

Homo sapiens

Schwann cell Colon endothelial cell Interstitial cell of cajal Pericyte Hematopoietic cell Mesodermal cell Paneth cell Ciliated cell Enteroendocrine cell Colon epithelial cell Mesothelial cell Epithelial cell Enterocyte Stromal cell Stem cell Goblet cell M cell of gut Neuron Endothelial cell Smooth muscle cell Intestinal tuft cell Basal cell

Colon Ileum Duodenum Intestine

Normal

10x 3' v2 Seq-well s3 10x 3' v3 10x 5' v2 Sort-seq

Cell Nucleus

Homo sapiens

Basal-myoepithelial cell of mammary gland Luminal hormone-sensing cell of mammary gland Luminal adaptive secretory precursor cell of mammary gland Mammary gland epithelial cell

Breast

52-year-old stage 65-year-old stage 41-year-old stage 35-year-old stage 63-year-old stage 37-year-old stage 29-year-old stage 58-year-old stage 24-year-old stage 34-year-old stage 31-year-old stage 59-year-old stage 25-year-old stage 57-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 20-year-old stage 36-year-old stage 45-year-old stage 40-year-old stage 62-year-old stage 19-year-old stage 39-year-old stage 28-year-old stage 38-year-old stage 23-year-old stage 30-year-old stage 27-year-old stage 48-year-old stage 33-year-old stage

Normal

Female

10x 3' v3

Cell

Homo sapiens

Non-classical monocyte Migratory dendritic cell Natural killer cell Cd8-alpha-positive thymic conventional dendritic cell Classical monocyte Kidney interstitial fibroblast Mast cell Renal interstitial pericyte Kidney loop of henle thin ascending limb epithelial cell Kidney collecting duct intercalated cell Group 3 innate lymphoid cell Kidney resident macrophage Epithelial cell of proximal tubule Kidney collecting duct principal cell Naive thymus-derived cd4-positive, alpha-beta t cell Macrophage Kidney loop of henle thick ascending limb epithelial cell Plasmacytoid dendritic cell, human Neural cell Cd8-alpha-negative thymic conventional dendritic cell Parietal epithelial cell Kidney distal convoluted tubule epithelial cell Plasma cell Mucosal invariant t cell Kidney connecting tubule epithelial cell Cycling macrophage Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Endothelial cell Kidney loop of henle thin descending limb epithelial cell Effector memory cd8-positive, alpha-beta t cell Naive regulatory t cell B cell Podocyte

Kidney

52-year-old stage 41-year-old stage 35-year-old stage Fifth decade stage Ninth decade stage 31-year-old stage 42-year-old stage 49-year-old stage 66-year-old stage 57-year-old stage Eighth decade stage Fourth decade stage 56-year-old stage Seventh decade stage 47-year-old stage 40-year-old stage Sixth decade stage 39-year-old stage 30-year-old stage 48-year-old stage Third decade stage

Normal Acute kidney failure Chronic kidney disease

Female Male

10x 3' v3

Cell

Homo sapiens

Non-classical monocyte Lung megakaryocyte Natural killer cell Mature conventional dendritic cell Neutrophil Alveolar type 1 fibroblast cell Classical monocyte Pulmonary alveolar type 1 cell Regulatory t cell Secondary crest myofibroblast Mast cell Vascular associated smooth muscle cell Myoepithelial cell Helper t cell Pericyte Alveolar adventitial fibroblast Alveolar capillary type 2 endothelial cell Deuterosomal cell Tracheobronchial smooth muscle cell Ciliated cell Mucus secreting cell of tracheobronchial tree submucosal gland Vein endothelial cell Cd8-positive, alpha-beta cytotoxic t cell Vein endothelial cell of respiratory system Lung interstitial macrophage Brush cell of tracheobronchial tree Conventional dendritic cell Pulmonary alveolar type 2 cell Alveolar capillary type 1 endothelial cell Airway submucosal gland collecting duct epithelial cell Plasma cell Ionocyte Alveolar macrophage Goblet cell Pulmonary neuroendocrine cell Plasmacytoid dendritic cell Serous secreting cell Mesothelial cell of pleura Secretory cell Innate lymphoid cell Chondrocyte Endothelial cell of respiratory system lymphatic vessel Endothelial cell of artery B cell Respiratory tract suprabasal cell Basal cell Lung secretory cell

Lung

80-year-old stage 64-year-old stage 26-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 41-year-old stage 35-year-old stage 63-year-old stage 37-year-old stage 29-year-old stage 24-year-old stage 22-year-old stage 75-year-old stage 31-year-old stage 42-year-old stage 49-year-old stage 59-year-old stage 54-year-old stage 25-year-old stage 12-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 21-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 47-year-old stage 20-year-old stage 36-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 13-year-old stage 62-year-old stage 10-year-old stage 39-year-old stage 38-year-old stage 23-year-old stage 30-year-old stage 79-year-old stage 72-year-old stage 27-year-old stage 17-year-old stage 48-year-old stage 51-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' v1

Cell

Mus musculus

Oligodendrocyte Medium spiny neuron Pericyte Vascular leptomeningeal cell Inhibitory interneuron Macrophage T cell Oligodendrocyte precursor cell Microglial cell Neuron Endothelial cell Cell Astrocyte

Brain ventricle Corpus callosum Cortical layer v Olfactory region Pia mater Cortical layer vi Striatum Cortical layer ii/iii

4-week-old stage 20-month-old stage and over 24-week-old stage

Normal

Female

Merfish

Homo sapiens

On parasol ganglion cell Off parasol ganglion cell On midget ganglion cell Retinal ganglion cell Off midget ganglion cell

Macula lutea proper Peripheral region of retina Macula lutea Fovea centralis

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 90 year-old and over stage 15-year-old stage 58-year-old stage 73-year-old stage Late adult stage 75-year-old stage 3-year-old stage 84-year-old stage 34-year-old stage 86-year-old stage 25-year-old stage 66-year-old stage 11-year-old stage 74-year-old stage Eighth decade stage 21-year-old stage 83-year-old stage 53-year-old stage 46-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 32-year-old stage 60-79 year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 88-year-old stage 60-year-old stage 62-year-old stage 16-year-old stage 10-year-old stage 18-year-old stage Prime adult stage 30-year-old stage 72-year-old stage 27-year-old stage 17-year-old stage 71-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

80 year-old and over stage 85-year-old stage 80-year-old stage 50-year-old stage 68-year-old stage 82-year-old stage 29-year-old stage 75-year-old stage 84-year-old stage 42-year-old stage 86-year-old stage 83-year-old stage 89-year-old stage 77-year-old stage 78-year-old stage 70-year-old stage 81-year-old stage 69-year-old stage 88-year-old stage 87-year-old stage 72-year-old stage

Normal Dementia

Female Male

10x 3' v3 10x multiome

Nucleus

Homo sapiens

Oligodendrocyte Natural killer cell Mast cell Monocyte Mural cell Malignant cell Macrophage Dendritic cell Mature t cell Oligodendrocyte precursor cell Plasma cell Microglial cell Neuron Endothelial cell B cell Radial glial cell Astrocyte

Left parietal lobe Right temporal lobe Left temporal lobe Left frontal lobe Temporal lobe Frontal lobe Right frontal lobe Brain Forebrain Right parietal lobe Temporoparietal junction

80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 63-year-old stage 58-year-old stage Adult stage 34-year-old stage 42-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 21-year-old stage 83-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 36-year-old stage 45-year-old stage 70-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 60-year-old stage 62-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage 33-year-old stage

Glioblastoma

Female Male

Cel-seq2 10x 3' v2 10x 3' v3 Bd rhapsody whole transcriptome analysis Microwell-seq Smart-seq2 Strt-seq 10x 5' v1

Cell

Homo sapiens

Megakaryocyte Non-classical monocyte Naive b cell Effector memory cd4-positive, alpha-beta t cell, terminally differentiated Classical monocyte Regulatory t cell Leukocyte Memory b cell Gamma-delta t cell Hematopoietic multipotent progenitor cell Unswitched memory b cell Central memory cd4-positive, alpha-beta t cell Plasmablast Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Conventional dendritic cell Plasma cell Central memory cd8-positive, alpha-beta t cell Effector memory cd4-positive, alpha-beta t cell Mucosal invariant t cell Plasmacytoid dendritic cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Cd16-positive, cd56-dim natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Blood

64-year-old stage 26-year-old stage 35-year-old stage 63-year-old stage 37-year-old stage 29-year-old stage 58-year-old stage 73-year-old stage Adult stage 22-year-old stage Late adult stage 34-year-old stage 49-year-old stage 59-year-old stage 57-year-old stage Eighth decade stage 21-year-old stage 53-year-old stage 46-year-old stage 55-year-old stage 44-year-old stage Seventh decade stage 32-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 40-year-old stage 62-year-old stage Sixth decade stage 39-year-old stage 28-year-old stage 38-year-old stage 30-year-old stage 27-year-old stage 51-year-old stage 71-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' v2 10x 5' v1

Cell

Homo sapiens

Megakaryocyte Natural killer cell Neutrophil Fibroblast Megakaryocyte-erythroid progenitor cell Malignant cell Macrophage T cell Myeloid cell Erythroid lineage cell Plasma cell B cell

Bone marrow Pleural fluid Blood

Pediatric stage Nursing stage (0-11 months)

T-cell childhood acute lymphocytic leukemia

Female Male

10x 5' v2

Cell

Homo sapiens

Schwann cell Mast cell Fibroblast Pericyte Myelinating schwann cell Macrophage Pigmented ciliary epithelial cell Trabecular meshwork cell Lymphocyte Non-pigmented ciliary epithelial cell Blood vessel endothelial cell Endothelial cell Ciliary muscle cell B cell Melanocyte

Eye trabecular meshwork Ciliary body

85-year-old stage 64-year-old stage 65-year-old stage 68-year-old stage 43-year-old stage 73-year-old stage 75-year-old stage 34-year-old stage 61-year-old stage 11-year-old stage 2-year-old stage 74-year-old stage 1-year-old stage 21-year-old stage 56-year-old stage 55-year-old stage 78-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage Newborn stage (0-28 days) 60-year-old stage 62-year-old stage 16-year-old stage 72-year-old stage 27-year-old stage 51-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' v2

Cell