Homo sapiens

Mature nk t cell Neutrophil Naive b cell Follicular dendritic cell Regulatory t cell Mast cell Pulmonary ionocyte Monocyte Club cell Squamous epithelial cell Memory b cell Ciliated cell Macrophage Gamma-delta t cell Dendritic cell T cell Cd8-positive, alpha-beta memory t cell Brush cell of trachea Multiciliated epithelial cell Plasmacytoid dendritic cell, human Cd4-positive, alpha-beta memory t cell Naive t cell Cd16-negative, cd56-bright natural killer cell, human Langerhans cell Conventional dendritic cell Plasma cell Mucosal invariant t cell Alternatively activated macrophage Secretory cell Duct epithelial cell Neuroendocrine cell Innate lymphoid cell Tracheal goblet cell Cd4-positive, alpha-beta t cell Cd16-positive, cd56-dim natural killer cell, human T follicular helper cell B cell Basal cell of epithelium of trachea Melanocyte

Bronchus Nasal cavity Trachea

52-year-old stage Juvenile stage (5-14 yo) 73-year-old stage Adult stage Late adult stage Pediatric stage 25-year-old stage Child stage (1-4 yo) 56-year-old stage 70-year-old stage 76-year-old stage Newborn stage (0-28 days) Postnatal stage 39-year-old stage

Normal Covid-19

Female Male

10x 5' v2 10x 5' v1

Cell

Callithrix jacchus

Glutamatergic neuron

Brodmann (1909) area 25 Dorsolateral prefrontal cortex Prefrontal cortex

Prime adult stage Late adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Stromal cell of ovary Schwann cell Keratocyte Tongue muscle cell Theca cell Vascular associated smooth muscle cell Fibroblast Mural cell Pericyte Tendon cell Alveolar adventitial fibroblast Mueller cell Fibroblast of breast Connective tissue cell Mesenchymal stem cell Leydig cell Glial cell Slow muscle cell Blood vessel smooth muscle cell Ventricular cardiac muscle cell Adipocyte Hepatic stellate cell Mesenchymal stem cell of adipose tissue Regular atrial cardiac myocyte Fibroblast of cardiac tissue Stromal cell Pancreatic stellate cell Bronchial smooth muscle cell Mesenchymal cell Myofibroblast cell Muscle cell Thymic fibroblast type 2 Myometrial cell Smooth muscle cell Adventitial cell Thymic fibroblast type 1 Melanocyte Fast muscle cell Skeletal muscle satellite stem cell

Abdominal aorta Adipose tissue Anterior part of tongue Anterior segment of eyeball Aorta Ascending colon Bladder organ Bone marrow Brown adipose tissue Buccal mucosa Cardiac atrium Cardiac ventricle Chorioretinal region Conjunctiva Cornea Coronary artery Crista ampullaris Duodenum Endocrine pancreas Endometrium Exocrine pancreas Eye Eyelid Heart Heart right ventricle Ileum Inferior vena cava Inguinal lymph node Jejunum Lacrimal gland Large intestine Left coronary artery Left ovary Liver Lung Lymph node Mammary gland Mesenteric lymph node Mucosa of stomach Muscle of abdomen Muscle of pelvic diaphragm Muscularis mucosae of stomach Myometrium Ocular surface region Ovary Parotid gland Posterior part of tongue Posterior segment of eyeball Prostate gland Retinal neural layer Right cardiac atrium Right ovary Sclera Sigmoid colon Skin of abdomen Skin of body Skin of chest Small intestine Spleen Stomach Stomach smooth muscle Subcutaneous adipose tissue Sublingual gland Submandibular gland Testis Thoracic aorta Thymus Tongue Trachea Uterus Utricle of membranous labyrinth Vasculature

26-year-old stage 37-year-old stage 59-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 36-year-old stage 45-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 60-year-old stage 38-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v3 Smart-seq3 10x 5' v2 Smart-seq2

Cell

Homo sapiens

Oligodendrocyte Immature astrocyte L6b glutamatergic cortical neuron Cajal-retzius cell Near-projecting glutamatergic cortical neuron Intratelencephalic-projecting glutamatergic cortical neuron Sst gabaergic interneuron L5 intratelencephalic projecting glutamatergic neuron Neural progenitor cell Committed oligodendrocyte precursor L2/3 intratelencephalic projecting glutamatergic neuron Lamp5 gabaergic interneuron Pvalb gabaergic interneuron L4 intratelencephalic projecting glutamatergic neuron Medial ganglionic eminence derived gabaergic interneuron Forebrain radial glial cell Oligodendrocyte precursor cell Sncg gabaergic interneuron Microglial cell Caudal ganglionic eminence derived interneuron Corticothalamic-projecting glutamatergic cortical neuron L6 intratelencephalic projecting glutamatergic neuron Brain vascular cell Gabaergic neuron Vip gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron Glutamatergic neuron Astrocyte

Brodmann (1909) area 10 Brodmann (1909) area 17 Brodmann (1909) area 9 Forebrain Neocortex Prefrontal cortex Telencephalon Visual cortex

Carnegie stage 21 31st week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage 32nd week post-fertilization stage 14th week post-fertilization stage 26th week post-fertilization stage 9th week post-fertilization stage 13th week post-fertilization stage Carnegie stage 23 33rd week post-fertilization stage 12th week post-fertilization stage 5-month-old stage 7-month-old stage 16th week post-fertilization stage 3-month-old stage 13-year-old stage 34th week post-fertilization stage 18th week post-fertilization stage 9-month-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

B cell

Ulcerative colitis

10x 5' v1

Homo sapiens

Intratelencephalic-projecting glutamatergic cortical neuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Cerebrocerebellum Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial zone of hypothalamus Midbrain tectum Middle temporal gyrus Nucleus accumbens Perirhinal cortex Piriform cortex Pontine nuclear group Posterior parahippocampal gyrus Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Septal nuclear complex Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Uncal ca1 Ventral anterior nucleus of thalamus

50-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Bladder urothelial cell Corneal epithelial cell Keratocyte Type l enteroendocrine cell Interstitial cell of cajal Pulmonary alveolar type 1 cell Medullary thymic epithelial cell Kidney epithelial cell Ciliated epithelial cell Pancreatic a cell Ovarian surface epithelial cell Type b pancreatic cell Paneth cell of epithelium of small intestine Intrahepatic cholangiocyte Myoepithelial cell Pulmonary ionocyte Club cell Enterocyte of epithelium of large intestine Large intestine goblet cell Paneth cell of colon Enterochromaffin-like cell Progenitor cell of mammary luminal epithelium Enteroendocrine cell Epithelial fate stem cell Multiciliated columnar cell of tracheobronchial tree Pancreatic d cell Transit amplifying cell of colon Mesothelial cell Retinal pigment epithelial cell Stratified squamous epithelial cell Intestinal crypt stem cell of colon Blood vessel smooth muscle cell Enterocyte of epithelium proper of ileum Small intestine goblet cell Myo-medullary thymic epithelial cell Serous cell of epithelium of bronchus Tuft cell of colon Sebocyte Pancreatic ductal cell Epithelial cell Hepatocyte Acinar cell of salivary gland Acinar cell Salivary gland cell Pulmonary alveolar type 2 cell Best4+ enterocyte Ionocyte Peritubular myoid cell Neuro-medullary thymic epithelial cell Enterocyte of epithelium proper of small intestine Conjunctival epithelial cell Glandular secretory epithelial cell Taste receptor cell Lung multiciliated epithelial cell Pancreatic pp cell Duct epithelial cell Vestibular dark cell Supporting cell of vestibular epithelium Tracheal goblet cell Respiratory tract goblet cell Enteroendocrine cell of small intestine Luminal epithelial cell of mammary gland Serous cell of epithelium of trachea Enterocyte of epithelium proper of duodenum Luminal cell of prostate epithelium Enterocyte of epithelium proper of jejunum Pancreatic acinar cell Transit amplifying cell of small intestine Mucus secreting cell Intestinal tuft cell Basal cell of prostate epithelium Basal cell Epithelial cell of uterus Intestinal crypt stem cell of small intestine

Anterior part of tongue Anterior segment of eyeball Ascending colon Bladder organ Buccal mucosa Cardiac atrium Cardiac ventricle Chorioretinal region Conjunctiva Cornea Cortex of kidney Crista ampullaris Duodenum Endocrine pancreas Endometrium Exocrine pancreas Eye Eyelid Heart Heart right ventricle Ileum Jejunum Kidney Lacrimal gland Large intestine Left ovary Liver Lung Mammary gland Mucosa of stomach Muscle of abdomen Muscle of pelvic diaphragm Myometrium Ocular surface region Ovary Parotid gland Posterior part of tongue Posterior segment of eyeball Prostate gland Right ovary Sclera Sigmoid colon Skin of abdomen Skin of body Skin of chest Small intestine Stomach Stomach smooth muscle Sublingual gland Submandibular gland Testis Thymus Tongue Trachea Uterus Utricle of membranous labyrinth

26-year-old stage 37-year-old stage 59-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 36-year-old stage 45-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 60-year-old stage 38-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v3 10x 5' v2 Smart-seq2

Cell

Homo sapiens

Natural killer cell Cd8-positive, alpha-beta t cell Endothelial cell of lymphatic vessel Mast cell Fibroblast Monocyte Pericyte Squamous epithelial cell Naive thymus-derived cd4-positive, alpha-beta t cell Macrophage Plasmacytoid dendritic cell, human Myeloid cell Blood vessel endothelial cell Conventional dendritic cell Cycling t cell Plasma cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Salivary gland glandular cell T follicular helper cell B cell

Alveolar ridge of mandible Buccal mucosa Gingiva of lower jaw Hypopharynx Larynx Mandible Mouth floor Oral cavity Oropharynx Tongue

80-year-old stage 64-year-old stage 50-year-old stage 65-year-old stage 43-year-old stage 35-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 53-year-old stage 56-year-old stage 55-year-old stage 77-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage 60-year-old stage 62-year-old stage 18-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage

Head and neck squamous cell carcinoma

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling

Cell

Homo sapiens

Caudal ganglionic eminence derived interneuron

Brodmann (1909) area 13 Brodmann (1909) area 14 Brodmann (1909) area 19 Brodmann (1909) area 23 Brodmann (1909) area 24 Brodmann (1909) area 25 Brodmann (1909) area 32 Brodmann (1909) area 38 Brodmann (1909) area 40 Brodmann (1909) area 43 Brodmann (1909) area 46 Accessory basal amygdaloid nucleus Agranular insular cortex Anterior cortical amygdaloid nucleus Anterior nuclear group Anterior olfactory nucleus Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Centromedian nucleus of thalamus Claustrum of brain Corticomedial nuclear complex Cuneus cortex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Extrastriate cortex Globus pallidus Granular insular cortex Gray matter of midbrain Hippocampal field Hypothalamus Inferior frontal gyrus Inferior olivary complex Inferior temporal gyrus Intralaminar nuclear group Lateral amygdaloid nucleus Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Median tuberal portion Midbrain nucleus Midbrain tectum Middle temporal gyrus Nucleus accumbens Nucleus of dorsal thalamus Nucleus of medulla oblongata Parabrachial nucleus Perirhinal cortex Piriform cortex Pontine nuclear group Pontine reticular formation Pontine tegmentum Posterior parahippocampal gyrus Preoptic area Pretectal region Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Pulvinar nucleus Putamen Red nucleus Retrosplenial region Rostral ca3 Septal nuclear complex Spinal cord Subicular complex Substantia innominata Substantia nigra Subthalamic nucleus Superior parietal cortex Superior temporal gyrus Supraoptic nucleus Temporal fusiform gyrus Uncal ca1 Ventral anterior nucleus of thalamus

50-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Retinal bipolar neuron Diffuse bipolar 3a cell Retinal cone cell H2 horizontal cell Diffuse bipolar 6 cell Gabaergic amacrine cell S cone cell Diffuse bipolar 2 cell Amacrine cell On parasol ganglion cell Rod bipolar cell Mueller cell Off parasol ganglion cell Diffuse bipolar 4 cell Retinal ganglion cell On-bipolar cell Flat midget bipolar cell Midget ganglion cell of retina Invaginating midget bipolar cell Retinal progenitor cell Diffuse bipolar 3b cell Diffuse bipolar 1 cell Retinal rod cell H1 horizontal cell Starburst amacrine cell Offx cell Glycinergic amacrine cell Retina horizontal cell

Macula lutea Peripheral region of retina Retina

24th week post-fertilization stage 15th week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage 14th week post-fertilization stage 9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 17th week post-fertilization stage 20th week post-fertilization stage

Normal

10x multiome

Nucleus

Homo sapiens

Non-classical monocyte Classical monocyte Macrophage Conventional dendritic cell Plasmacytoid dendritic cell

Blood Bone marrow Epithelial lining fluid Inguinal lymph node Jejunal epithelium Jejunum lamina propria Lung Mesenteric lymph node Spleen Thoracic lymph node

64-year-old stage 68-year-old stage Fifth decade stage 73-year-old stage 75-year-old stage 25-year-old stage Eighth decade stage Fourth decade stage 56-year-old stage 20-year-old stage 67-year-old stage Sixth decade stage 23-year-old stage 27-year-old stage 48-year-old stage 33-year-old stage Third decade stage

Normal

Female Male

10x 3' v3 10x 5' v2

Cell

Homo sapiens

Mature nk t cell Non-classical monocyte Natural killer cell Mast cell Monocyte Kidney interstitial cell Kidney loop of henle thin ascending limb epithelial cell Kidney collecting duct intercalated cell Epithelial cell of proximal tubule Kidney collecting duct principal cell Kidney interstitial alternatively activated macrophage T cell Kidney loop of henle thick ascending limb epithelial cell Mononuclear phagocyte Cytotoxic t cell Plasmacytoid dendritic cell, human Parietal epithelial cell Kidney distal convoluted tubule epithelial cell Conventional dendritic cell Plasma cell Kidney connecting tubule epithelial cell Endothelial cell Kidney loop of henle thin descending limb epithelial cell B cell Podocyte

Kidney

52-year-old stage 41-year-old stage 35-year-old stage Fifth decade stage Ninth decade stage 31-year-old stage 42-year-old stage 49-year-old stage 66-year-old stage 57-year-old stage Eighth decade stage 53-year-old stage Fourth decade stage 56-year-old stage Seventh decade stage 47-year-old stage 40-year-old stage Sixth decade stage 39-year-old stage 30-year-old stage 48-year-old stage Third decade stage

Normal Acute kidney failure Chronic kidney disease

Female Male

10x 3' v3

Cell