Homo sapiens

L6b glutamatergic cortical neuron L4 intratelencephalic projecting glutamatergic neuron Neural progenitor cell Astrocyte Lamp5 gabaergic interneuron L6 intratelencephalic projecting glutamatergic neuron Gabaergic neuron Corticothalamic-projecting glutamatergic cortical neuron Committed oligodendrocyte precursor L2/3 intratelencephalic projecting glutamatergic neuron Immature astrocyte Vip gabaergic interneuron Oligodendrocyte precursor cell Caudal ganglionic eminence derived interneuron Oligodendrocyte Medial ganglionic eminence derived gabaergic interneuron L5 intratelencephalic projecting glutamatergic neuron Brain vascular cell Pvalb gabaergic interneuron Glutamatergic neuron Cajal-retzius cell Sncg gabaergic interneuron Intratelencephalic-projecting glutamatergic cortical neuron Sst gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron Forebrain radial glial cell Near-projecting glutamatergic cortical neuron Microglial cell

Brodmann (1909) area 10 Neocortex Brodmann (1909) area 17 Forebrain Telencephalon Prefrontal cortex Visual cortex Brodmann (1909) area 9

34th week post-fertilization stage 21st week post-fertilization stage 14th week post-fertilization stage Carnegie stage 21 7-month-old stage 33rd week post-fertilization stage 13-year-old stage Carnegie stage 23 9-month-old stage 16th week post-fertilization stage 32nd week post-fertilization stage 26th week post-fertilization stage 3-month-old stage 31st week post-fertilization stage 11th week post-fertilization stage 13th week post-fertilization stage 5-month-old stage 12th week post-fertilization stage 18th week post-fertilization stage 9th week post-fertilization stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

B cell

Ulcerative colitis

10x 5' v1

Homo sapiens

Neuron

Intralaminar nuclear group Primary motor cortex Perirhinal cortex Inferior temporal gyrus Dentate gyrus of hippocampal formation Cerebrocerebellum Primary visual cortex Ventral anterior nucleus of thalamus Brodmann (1909) area 46 Subthalamic nucleus Globus pallidus Nucleus accumbens Primary somatosensory cortex Midbrain tectum Inferior frontal gyrus Epithalamus Cuneus cortex Retrosplenial region Medial dorsal nucleus of thalamus Medial zone of hypothalamus Putamen Brodmann (1909) area 25 Red nucleus Corticomedial nuclear complex Brodmann (1909) area 14 Brodmann (1909) area 19 Piriform cortex Accessory basal amygdaloid nucleus Anterior olfactory nucleus Hypothalamus Granular insular cortex Brodmann (1909) area 32 Superior temporal gyrus Substantia nigra Primary auditory cortex Brodmann (1909) area 24 Uncal ca1 Anterior cortical amygdaloid nucleus Lateral entorhinal cortex Septal nuclear complex Basolateral amygdaloid nuclear complex Middle temporal gyrus Brodmann (1909) area 38 Agranular insular cortex Pulvinar nucleus Body of caudate nucleus Temporal fusiform gyrus Extrastriate cortex Brodmann (1909) area 23 Medial entorhinal cortex Lateral amygdaloid nucleus Supraoptic nucleus Posterior parahippocampal gyrus Pontine nuclear group Superior parietal cortex Substantia innominata Bed nucleus of stria terminalis Brodmann (1909) area 13 Gray matter of midbrain Mammillary body Central amygdaloid nucleus Subicular complex Brodmann (1909) area 43 Hippocampal field Brodmann (1909) area 40 Claustrum of brain Pretectal region Lateral posterior nucleus of thalamus

42-year-old stage 50-year-old stage 29-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Small intestine goblet cell Pancreatic d cell Salivary gland cell Pancreatic pp cell Serous cell of epithelium of trachea Enteroendocrine cell Pulmonary ionocyte Pancreatic ductal cell Enterocyte of epithelium proper of jejunum Luminal epithelial cell of mammary gland Multiciliated columnar cell of tracheobronchial tree Intestinal crypt stem cell of small intestine Ionocyte Pancreatic a cell Serous cell of epithelium of bronchus Pancreatic acinar cell Stratified squamous epithelial cell Acinar cell Luminal cell of prostate epithelium Keratocyte Paneth cell of colon Paneth cell of epithelium of small intestine Taste receptor cell Neuro-medullary thymic epithelial cell Progenitor cell of mammary luminal epithelium Epithelial cell of uterus Intestinal tuft cell Enterocyte of epithelium proper of small intestine Tracheal goblet cell Epithelial cell Conjunctival epithelial cell Respiratory tract goblet cell Type l enteroendocrine cell Interstitial cell of cajal Enterocyte of epithelium of large intestine Enterochromaffin-like cell Transit amplifying cell of small intestine Myoepithelial cell Intrahepatic cholangiocyte Large intestine goblet cell Medullary thymic epithelial cell Retinal pigment epithelial cell Mucus secreting cell Enterocyte of epithelium proper of ileum Enterocyte of epithelium proper of duodenum Club cell Ovarian surface epithelial cell Hepatocyte Vestibular dark cell Kidney epithelial cell Pulmonary alveolar type 2 cell Glandular secretory epithelial cell Peritubular myoid cell Duct epithelial cell Basal cell of prostate epithelium Myo-medullary thymic epithelial cell Pulmonary alveolar type 1 cell Blood vessel smooth muscle cell Tuft cell of colon Ciliated epithelial cell Sebocyte Bladder urothelial cell Transit amplifying cell of colon Best4+ enterocyte Type b pancreatic cell Basal cell Corneal epithelial cell Supporting cell of vestibular epithelium Mesothelial cell Epithelial fate stem cell Lung multiciliated epithelial cell Intestinal crypt stem cell of colon Acinar cell of salivary gland Enteroendocrine cell of small intestine

Skin of body Trachea Cardiac ventricle Chorioretinal region Myometrium Lacrimal gland Stomach Cortex of kidney Ascending colon Endometrium Sigmoid colon Lung Crista ampullaris Bladder organ Liver Mucosa of stomach Conjunctiva Exocrine pancreas Ileum Stomach smooth muscle Muscle of abdomen Cornea Right ovary Prostate gland Skin of chest Large intestine Sclera Cardiac atrium Tongue Posterior part of tongue Kidney Sublingual gland Eyelid Ovary Anterior part of tongue Uterus Muscle of pelvic diaphragm Small intestine Thymus Left ovary Ocular surface region Buccal mucosa Posterior segment of eyeball Heart Skin of abdomen Jejunum Heart right ventricle Anterior segment of eyeball Duodenum Parotid gland Mammary gland Submandibular gland Testis Endocrine pancreas Eye Utricle of membranous labyrinth

74-year-old stage 26-year-old stage 61-year-old stage 57-year-old stage 36-year-old stage 40-year-old stage 38-year-old stage 45-year-old stage 59-year-old stage 55-year-old stage 33-year-old stage 69-year-old stage 60-year-old stage 56-year-old stage 37-year-old stage 46-year-old stage 67-year-old stage

Normal

Female Male

10x 3' v3 10x 5' v2 Smart-seq2

Cell

Homo sapiens

Fibroblast Myeloid cell Mast cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Plasma cell B cell Blood vessel endothelial cell Naive thymus-derived cd4-positive, alpha-beta t cell Pericyte Salivary gland glandular cell Plasmacytoid dendritic cell, human Cd8-positive, alpha-beta t cell Endothelial cell of lymphatic vessel Natural killer cell Macrophage Conventional dendritic cell Monocyte Squamous epithelial cell Cycling t cell T follicular helper cell

Mandible Gingiva of lower jaw Tongue Larynx Alveolar ridge of mandible Oral cavity Oropharynx Buccal mucosa Hypopharynx Mouth floor

54-year-old stage 35-year-old stage 62-year-old stage 73-year-old stage 74-year-old stage 72-year-old stage 53-year-old stage 61-year-old stage 57-year-old stage 48-year-old stage 70-year-old stage 45-year-old stage 55-year-old stage 58-year-old stage 75-year-old stage 18-year-old stage 50-year-old stage 51-year-old stage 64-year-old stage 66-year-old stage 77-year-old stage 69-year-old stage 32-year-old stage 60-year-old stage 80-year-old stage 56-year-old stage 67-year-old stage 43-year-old stage 65-year-old stage

Head and neck squamous cell carcinoma

Female Male

10x 5' transcription profiling 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Neuron

Intralaminar nuclear group Primary motor cortex Perirhinal cortex Inferior temporal gyrus Dentate gyrus of hippocampal formation Primary visual cortex Ventral anterior nucleus of thalamus Brodmann (1909) area 46 Subthalamic nucleus Globus pallidus Nucleus accumbens Primary somatosensory cortex Midbrain tectum Lateral nuclear group of thalamus Inferior frontal gyrus Epithalamus Cuneus cortex Retrosplenial region Medial dorsal nucleus of thalamus Medial zone of hypothalamus Putamen Lateral geniculate body Brodmann (1909) area 25 Nucleus of medulla oblongata Red nucleus Corticomedial nuclear complex Nucleus of dorsal thalamus Brodmann (1909) area 14 Pontine reticular formation Brodmann (1909) area 19 Midbrain nucleus Piriform cortex Pontine tegmentum Accessory basal amygdaloid nucleus Anterior olfactory nucleus Hypothalamus Granular insular cortex Centromedian nucleus of thalamus Brodmann (1909) area 32 Superior temporal gyrus Substantia nigra Primary auditory cortex Brodmann (1909) area 24 Uncal ca1 Anterior cortical amygdaloid nucleus Lateral entorhinal cortex Septal nuclear complex Basolateral amygdaloid nuclear complex Spinal cord Preoptic area Middle temporal gyrus Parabrachial nucleus Brodmann (1909) area 38 Agranular insular cortex Pulvinar nucleus Body of caudate nucleus Temporal fusiform gyrus Extrastriate cortex Brodmann (1909) area 23 Medial entorhinal cortex Lateral amygdaloid nucleus Supraoptic nucleus Posterior parahippocampal gyrus Pontine nuclear group Median tuberal portion Superior parietal cortex Dorsal tegmental nucleus Substantia innominata Bed nucleus of stria terminalis Brodmann (1909) area 13 Medial geniculate body Inferior olivary complex Gray matter of midbrain Mammillary body Anterior nuclear group Central amygdaloid nucleus Subicular complex Brodmann (1909) area 43 Hippocampal field Rostral ca3 Brodmann (1909) area 40 Claustrum of brain Pretectal region Lateral posterior nucleus of thalamus

42-year-old stage 50-year-old stage 29-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Retinal ganglion cell H1 horizontal cell Retinal rod cell Offx cell Off parasol ganglion cell Invaginating midget bipolar cell H2 horizontal cell Gabaergic amacrine cell Amacrine cell Retina horizontal cell Retinal bipolar neuron Retinal progenitor cell Diffuse bipolar 3b cell Diffuse bipolar 4 cell S cone cell Diffuse bipolar 3a cell Glycinergic amacrine cell Diffuse bipolar 6 cell Starburst amacrine cell Midget ganglion cell of retina On parasol ganglion cell Rod bipolar cell Flat midget bipolar cell Retinal cone cell Diffuse bipolar 1 cell Diffuse bipolar 2 cell On-bipolar cell Mueller cell

Peripheral region of retina Retina Macula lutea

21st week post-fertilization stage 14th week post-fertilization stage 20th week post-fertilization stage 15th week post-fertilization stage 11th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 24th week post-fertilization stage 9th week post-fertilization stage 17th week post-fertilization stage

Normal

10x multiome

Nucleus

Homo sapiens

Non-classical monocyte Plasmacytoid dendritic cell Macrophage Conventional dendritic cell Classical monocyte

Lung Mesenteric lymph node Jejunal epithelium Blood Epithelial lining fluid Bone marrow Spleen Thoracic lymph node Jejunum lamina propria Inguinal lymph node

27-year-old stage 73-year-old stage Third decade stage Sixth decade stage Fourth decade stage 48-year-old stage Eighth decade stage 23-year-old stage 75-year-old stage 64-year-old stage 68-year-old stage 33-year-old stage Fifth decade stage 25-year-old stage 56-year-old stage 67-year-old stage 20-year-old stage

Normal

Female Male

10x 3' v3 10x 5' v2

Cell

Homo sapiens

Kidney loop of henle thin descending limb epithelial cell Cytotoxic t cell Kidney interstitial cell Kidney loop of henle thick ascending limb epithelial cell Parietal epithelial cell Mast cell Epithelial cell of proximal tubule Podocyte Kidney connecting tubule epithelial cell Mononuclear phagocyte Plasma cell B cell Non-classical monocyte Kidney interstitial alternatively activated macrophage Plasmacytoid dendritic cell, human Kidney loop of henle thin ascending limb epithelial cell Kidney distal convoluted tubule epithelial cell Natural killer cell Kidney collecting duct intercalated cell Conventional dendritic cell Monocyte Mature nk t cell Kidney collecting duct principal cell T cell Endothelial cell

Kidney

35-year-old stage 39-year-old stage 53-year-old stage Ninth decade stage Third decade stage 57-year-old stage Sixth decade stage 49-year-old stage 42-year-old stage Fourth decade stage 52-year-old stage 48-year-old stage 40-year-old stage 41-year-old stage Eighth decade stage 30-year-old stage 66-year-old stage Fifth decade stage 31-year-old stage 56-year-old stage Seventh decade stage 47-year-old stage

Chronic kidney disease Acute kidney failure Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Neuron

Intralaminar nuclear group Primary motor cortex Perirhinal cortex Cerebellar nuclear complex Inferior temporal gyrus Dentate gyrus of hippocampal formation Primary visual cortex Ventral anterior nucleus of thalamus Brodmann (1909) area 46 Subthalamic nucleus Globus pallidus Nucleus accumbens Primary somatosensory cortex Midbrain tectum Lateral nuclear group of thalamus Inferior frontal gyrus Epithalamus Cuneus cortex Retrosplenial region Medial dorsal nucleus of thalamus Medial zone of hypothalamus Putamen Lateral geniculate body Brodmann (1909) area 25 Nucleus of medulla oblongata Red nucleus Corticomedial nuclear complex Nucleus of dorsal thalamus Brodmann (1909) area 14 Brodmann (1909) area 19 Piriform cortex Accessory basal amygdaloid nucleus Anterior olfactory nucleus Hypothalamus Granular insular cortex Centromedian nucleus of thalamus Brodmann (1909) area 32 Superior temporal gyrus Substantia nigra Primary auditory cortex Brodmann (1909) area 24 Uncal ca1 Anterior cortical amygdaloid nucleus Lateral entorhinal cortex Septal nuclear complex Basolateral amygdaloid nuclear complex Preoptic area Middle temporal gyrus Parabrachial nucleus Brodmann (1909) area 38 Agranular insular cortex Pulvinar nucleus Body of caudate nucleus Temporal fusiform gyrus Extrastriate cortex Brodmann (1909) area 23 Medial entorhinal cortex Lateral amygdaloid nucleus Supraoptic nucleus Posterior parahippocampal gyrus Pontine nuclear group Median tuberal portion Superior parietal cortex Substantia innominata Bed nucleus of stria terminalis Brodmann (1909) area 13 Medial geniculate body Inferior olivary complex Gray matter of midbrain Mammillary body Anterior nuclear group Central amygdaloid nucleus Subicular complex Brodmann (1909) area 43 Hippocampal field Rostral ca3 Brodmann (1909) area 40 Claustrum of brain Pretectal region Lateral posterior nucleus of thalamus

42-year-old stage 50-year-old stage 29-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Enteroendocrine cell Transit amplifying cell Enterocyte Tuft cell of small intestine Paneth cell Intestine goblet cell Mucous neck cell of gastric gland Foveolar cell of stomach Best4+ enterocyte Intestinal crypt stem cell M cell of gut

Ileum lamina propria Ileal epithelium Mesenteric lymph node Ileum Small intestine Duodenal epithelium Jejunum Duodenum Epithelium of small intestine Lamina propria of small intestine

9-year-old stage Third decade stage 13-year-old stage Sixth decade stage 36-year-old stage 4-year-old stage Fourth decade stage 52-year-old stage 6-year-old stage 12-year-old stage 45-year-old stage Eighth decade stage 10-year-old stage 14-year-old stage 22-year-old stage 18-year-old stage 50-year-old stage 29-year-old stage 11-year-old stage Fifth decade stage 31-year-old stage 87-year-old stage 60-year-old stage Prime adult stage 25-year-old stage 56-year-old stage 37-year-old stage 67-year-old stage 20-year-old stage Seventh decade stage

Crohn disease Celiac disease Normal

Female Male

10x 5' transcription profiling 10x 3' v3 10x 3' v1 10x 5' v2 10x 5' v1 10x 3' v2

Cell

Homo sapiens

Fibroblast Schwann cell Endocardial cell Smooth muscle cell Cardiac muscle cell Pericyte Lymphocyte Adipocyte Macrophage Cardiac blood vessel endothelial cell Mesothelial cell Neuron

Right atrium auricular region

Ninth decade stage Sixth decade stage Eighth decade stage Fifth decade stage Seventh decade stage

Heart valve disorder Heart failure Myocardial ischemia Normal

Female Male

10x 3' v3

Nucleus