Homo sapiens

Pancreatic d cell Pancreatic pp cell Pancreatic ductal cell Schwann cell Pancreatic a cell Pancreatic acinar cell Mast cell Pancreatic epsilon cell Leukocyte Type b pancreatic cell Pancreatic stellate cell Endothelial cell

Islet of langerhans

54-year-old stage 35-year-old stage 62-year-old stage 26-year-old stage 53-year-old stage 21-year-old stage 61-year-old stage 57-year-old stage 49-year-old stage 42-year-old stage 52-year-old stage 48-year-old stage 40-year-old stage 38-year-old stage 45-year-old stage 59-year-old stage 30-year-old stage 55-year-old stage 58-year-old stage 50-year-old stage 51-year-old stage 66-year-old stage 32-year-old stage 63-year-old stage 60-year-old stage 25-year-old stage 37-year-old stage 34-year-old stage

Type 2 diabetes mellitus Prediabetes syndrome Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Mus musculus

Fibroblast Pancreatic d cell Pancreatic pp cell Kupffer cell Pancreatic ductal cell Professional antigen presenting cell Kidney capillary endothelial cell Kidney loop of henle thick ascending limb epithelial cell Double negative thymocyte Schwann cell Kidney cell Luminal epithelial cell of mammary gland Kidney loop of henle ascending limb epithelial cell Keratinocyte Multiciliated columnar cell of tracheobronchial tree Myeloid cell Kidney proximal convoluted tubule epithelial cell Pancreatic a cell Pancreatic acinar cell Macrophage dendritic cell progenitor Kidney collecting duct epithelial cell Endothelial cell of coronary artery Mast cell Langerhans cell Epithelial cell of proximal tubule Granulocyte Vein endothelial cell Mesenchymal stem cell Epidermal cell Intermediate monocyte Endocardial cell Alveolar macrophage Naive t cell Smooth muscle cell Myeloid dendritic cell Hematopoietic precursor cell Basophil Neutrophil Dn3 thymocyte Epithelial cell Stromal cell Proerythroblast Smooth muscle cell of trachea Enterocyte of epithelium of large intestine Plasma cell Immature b cell Cardiac muscle cell Basal cell of epidermis Dendritic cell Basal epithelial cell of tracheobronchial tree B cell Regulatory t cell Mesenchymal cell Chondrocyte Blood cell Large intestine goblet cell Fibroblast of lung Tuft cell Myeloid leukocyte Pericyte Late pro-b cell Club cell Stem cell of epidermis Smooth muscle cell of the pulmonary artery Hepatocyte Hematopoietic stem cell Non-classical monocyte Precursor b cell Pulmonary alveolar type 2 cell Plasmacytoid dendritic cell Lymphocyte Granulocytopoietic cell Kidney proximal straight tubule epithelial cell Leukocyte Duct epithelial cell Cd8-positive, alpha-beta t cell Cell of skeletal muscle Promonocyte Kidney distal convoluted tubule epithelial cell Mesangial cell Megakaryocyte-erythroid progenitor cell Endothelial cell of lymphatic vessel Lung macrophage Kidney cortex artery cell Natural killer cell Endothelial cell of hepatic sinusoid Macrophage Erythroid progenitor cell, mammalian Hepatic stellate cell Neuroendocrine cell Cardiac neuron Bladder urothelial cell Skeletal muscle satellite cell Fenestrated endothelial cell Erythroblast Bronchial smooth muscle cell Erythrocyte Type b pancreatic cell Mesenchymal stem cell of adipose tissue Thymocyte Monocyte Intestinal crypt stem cell Pulmonary interstitial fibroblast Mature nk t cell Basal cell Classical monocyte Epithelial cell of large intestine Kidney collecting duct principal cell Adventitial cell Pancreatic stellate cell Cd4-positive, alpha-beta t cell Fibroblast of cardiac tissue T cell Keratinocyte stem cell Naive b cell Dn4 thymocyte Immature nk t cell Immature t cell Pulmonary neuroendocrine cell Endothelial cell Plasmatocyte Bladder cell

Skin of body Trachea Lung Liver Bladder lumen Limb muscle Large intestine Bone marrow Tongue Kidney Adipose tissue Spleen Thymus Pancreas Heart Mammary gland

4-week-old stage 20-month-old stage and over 3-month-old stage 18-month-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Retinal rod cell Glial cell Amacrine cell Retina horizontal cell Retinal bipolar neuron Retinal cone cell

Peripheral region of retina Fovea centralis Macula lutea proper

78-year-old stage 73-year-old stage 83-year-old stage 84-year-old stage 65-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Microcebus murinus

Small intestine goblet cell Secretory cell Fibroblast Pancreatic d cell Kidney loop of henle thin descending limb epithelial cell Pancreatic pp cell Urothelial cell Innate lymphoid cell Regular atrial cardiac myocyte Mesothelial cell of epicardium Off-bipolar cell Gonadtroph Pancreatic ductal cell Kidney loop of henle thick ascending limb epithelial cell Retinal rod cell Brush cell of trachea Slow muscle cell Myeloid cell Kidney proximal convoluted tubule epithelial cell Pancreatic a cell Astrocyte Pancreatic acinar cell Spermatid Purkinje myocyte Langerhans cell Leptomeningeal cell Epithelial cell of proximal tubule Podocyte Renal alpha-intercalated cell Gabaergic neuron Vasa recta ascending limb cell Regular ventricular cardiac myocyte Vein endothelial cell Myelinating schwann cell Reticular cell Mesenchymal stem cell Epidermal cell Brush cell of bronchus Alveolar macrophage Epithelial cell of uterus Hair follicle cell Smooth muscle cell Basal cell of epithelium of bronchus Intestinal tuft cell Hematopoietic precursor cell Retina horizontal cell Retinal bipolar neuron Basophil Melanocyte Neutrophil Oligodendrocyte precursor cell Epithelial cell Stromal cell Granulosa cell Vasa recta descending limb cell Interstitial cell of cajal Enterocyte of epithelium of large intestine Plasma cell Enterocyte of epithelium of small intestine Nodal myocyte Oligodendrocyte Cardiac muscle cell Basal cell of epidermis Corticotroph Dendritic cell B cell Chondrocyte Non-myelinating schwann cell Intestinal enteroendocrine cell Intrahepatic cholangiocyte Vascular associated smooth muscle cell Large intestine goblet cell Fibroblast of lung Endothelial cell of sinusoid Capillary endothelial cell Somatotroph Erythroid progenitor cell Renal beta-intercalated cell Pericyte Spermatogonium Myofibroblast cell Club cell Renal principal cell Hepatocyte Basal cell of epithelium of trachea Pulmonary alveolar type 2 cell Plasmacytoid dendritic cell Skeletal muscle satellite stem cell Erythroid lineage cell Kidney loop of henle thin ascending limb epithelial cell Lymphocyte Kidney proximal straight tubule epithelial cell Preosteoblast Eosinophil Adipocyte Cd8-positive, alpha-beta t cell Kidney distal convoluted tubule epithelial cell Pulmonary alveolar type 1 cell Ependymal cell Endothelial cell of lymphatic vessel Tendon cell Granulocyte monocyte progenitor cell Glutamatergic neuron Natural killer cell Endothelial cell of hepatic sinusoid Macrophage Retinal cone cell Thyrotroph Renal intercalated cell Mammotroph Neuroendocrine cell Epithelial cell of exocrine pancreas Platelet Oral mucosa squamous cell Bladder urothelial cell Epithelial cell of small intestine Kidney collecting duct intercalated cell On-bipolar cell Kidney loop of henle epithelial cell Type b pancreatic cell Macula densa epithelial cell Osteoblast Conventional dendritic cell Ciliated cell Monocyte Mueller cell Mature nk t cell Epithelial cell of large intestine Mesothelial cell Pancreatic endocrine cell Cd4-positive, alpha-beta t cell Choroid plexus epithelial cell T cell Spermatocyte Neuron Megakaryocyte progenitor cell Glomerular endothelial cell M cell of gut Epithelial cell of sweat gland Fast muscle cell Endothelial cell Endothelial cell of artery

Skin of body Trachea Cardiac muscle tissue Heart left ventricle Brown adipose tissue Cerebral cortex Retina Bone element Lung Aorta Subcutaneous adipose tissue Mesenteric fat pad Liver Gonadal fat pad Left cardiac atrium Blood Right cardiac atrium Limb muscle Brainstem Bone marrow Tongue Kidney Adipose tissue Urinary bladder Spleen Uterus Small intestine Thymus Pancreas Heart Heart right ventricle Diaphragm Epithelium of tongue Tongue muscle Vertebral column Mammary gland Hypothalamus-pituitary axis Testis Limb bone Colon

Post-juvenile adult stage

Normal

Female Male

Smart-seq2 10x 3' v2

Cell

Homo sapiens

Malignant cell

Breast

54-year-old stage 35-year-old stage Adult stage 62-year-old stage 80 year-old and over stage 73-year-old stage Ninth decade stage 83-year-old stage 85-year-old stage 61-year-old stage 57-year-old stage Sixth decade stage 82-year-old stage 49-year-old stage 42-year-old stage 36-year-old stage 52-year-old stage 70-year-old stage 38-year-old stage 45-year-old stage 41-year-old stage 59-year-old stage Eighth decade stage 30-year-old stage 55-year-old stage 58-year-old stage 50-year-old stage 79-year-old stage 64-year-old stage 29-year-old stage 66-year-old stage Late adult stage 69-year-old stage 32-year-old stage Fifth decade stage 88-year-old stage 63-year-old stage 60-year-old stage 80-year-old stage Prime adult stage 84-year-old stage 25-year-old stage 37-year-old stage Middle aged stage 46-year-old stage 67-year-old stage 43-year-old stage 60-79 year-old stage 65-year-old stage 71-year-old stage Seventh decade stage 34-year-old stage 47-year-old stage

Invasive lobular breast carcinoma Breast apocrine carcinoma Her2 positive breast carcinoma Breast mucinous carcinoma Breast carcinoma Triple-negative breast carcinoma Invasive ductal breast carcinoma Invasive tubular breast carcinoma Breast cancer Metaplastic breast carcinoma Estrogen-receptor positive breast cancer

Female Male

10x 5' transcription profiling 10x 3' v3 10x 5' v2 10x 5' v1 10x 3' v2

Cell

Homo sapiens

L6b glutamatergic cortical neuron Lamp5 gabaergic interneuron Astrocyte of the cerebral cortex Corticothalamic-projecting glutamatergic cortical neuron Pvalb chandelier gabaergic interneuron Vip gabaergic interneuron Oligodendrocyte precursor cell Caudal ganglionic eminence derived interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron Oligodendrocyte Cerebral cortex endothelial cell Pvalb gabaergic interneuron Sncg gabaergic interneuron Sst gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron Near-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Microglial cell

Primary visual cortex

42-year-old stage 50-year-old stage 29-year-old stage 60-year-old stage 43-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Luminal epithelial cell of mammary gland Mammary gland epithelial cell Basal cell

Breast

Adult stage Prime adult stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Innate lymphoid cell Double negative thymocyte B-1 b cell Common myeloid progenitor Hematopoietic multipotent progenitor cell Large pre-b-ii cell Group 2 innate lymphoid cell Early lymphoid progenitor Fraction a pre-pro b cell Pro-b cell Small pre-b-ii cell Plasma cell Immature b cell Regulatory t cell Megakaryocyte B-2 b cell Naive thymus-derived cd4-positive, alpha-beta t cell Late pro-b cell Naive thymus-derived cd8-positive, alpha-beta t cell Hematopoietic stem cell Promonocyte Megakaryocyte-erythroid progenitor cell Granulocyte monocyte progenitor cell Natural killer cell Mature b cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell Group 3 innate lymphoid cell Promyelocyte T cell Double-positive, alpha-beta thymocyte

Skin of body Mesenteric lymph node Liver Gut wall Bone marrow Kidney Spleen Yolk sac Thymus

Carnegie stage 19 Carnegie stage 20 14th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 23 16th week post-fertilization stage Carnegie stage 22 Carnegie stage 13 15th week post-fertilization stage 11th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 9th week post-fertilization stage 17th week post-fertilization stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Plasmablast Double negative thymocyte Mucosal invariant t cell Iga plasmablast Effector memory cd8-positive, alpha-beta t cell Cd4-positive, alpha-beta cytotoxic t cell Central memory cd4-positive, alpha-beta t cell Activated cd4-positive, alpha-beta t cell, human Neutrophil Memory b cell Immature neutrophil Gamma-delta t cell Regulatory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Hematopoietic stem cell Non-classical monocyte Plasmacytoid dendritic cell, human Lymphocyte Igg plasmablast Cd16-negative, cd56-bright natural killer cell, human Natural killer cell Platelet Erythrocyte Activated cd8-positive, alpha-beta t cell, human Conventional dendritic cell Classical monocyte Naive b cell Transitional stage b cell

Blood

54-year-old stage Adult stage 39-year-old stage 62-year-old stage 27-year-old stage 78-year-old stage 80 year-old and over stage 73-year-old stage 53-year-old stage Third decade stage 61-year-old stage Sixth decade stage 82-year-old stage 49-year-old stage 36-year-old stage Fourth decade stage 48-year-old stage 70-year-old stage 38-year-old stage 59-year-old stage Eighth decade stage 75-year-old stage 68-year-old stage 29-year-old stage Fifth decade stage 63-year-old stage 60-year-old stage 84-year-old stage 37-year-old stage 46-year-old stage 67-year-old stage Seventh decade stage 47-year-old stage

Covid-19 Normal

Female Male

10x 3' v3 Seq-well 10x 3' v2

Cell

Homo sapiens

Secretory cell Innate lymphoid cell Pulmonary ionocyte Brush cell of trachea Mucosal invariant t cell Multiciliated epithelial cell Cd16-positive, cd56-dim natural killer cell, human Mast cell Langerhans cell Naive t cell Melanocyte Neutrophil Tracheal goblet cell Cd4-positive, alpha-beta memory t cell Memory b cell Follicular dendritic cell Plasma cell Dendritic cell B cell Gamma-delta t cell Regulatory t cell Club cell Plasmacytoid dendritic cell, human Basal cell of epithelium of trachea Duct epithelial cell Cd16-negative, cd56-bright natural killer cell, human Macrophage Neuroendocrine cell Alternatively activated macrophage Conventional dendritic cell Ciliated cell Monocyte Squamous epithelial cell Mature nk t cell Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta t cell T cell Naive b cell T follicular helper cell

Trachea Bronchus Nasal cavity

Adult stage 39-year-old stage 73-year-old stage Postnatal stage Juvenile stage (5-14 yo) Newborn stage (0-28 days) 52-year-old stage 70-year-old stage Late adult stage Child stage (1-4 yo) 76-year-old stage 25-year-old stage 56-year-old stage Pediatric stage

Covid-19 Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Callithrix jacchus

Glutamatergic neuron

Dorsolateral prefrontal cortex Brodmann (1909) area 25 Prefrontal cortex

Prime adult stage Late adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Fibroblast Regular atrial cardiac myocyte Slow muscle cell Schwann cell Keratocyte Glial cell Mesenchymal stem cell Smooth muscle cell Mural cell Melanocyte Stromal cell Mesenchymal cell Leydig cell Vascular associated smooth muscle cell Pericyte Myofibroblast cell Stromal cell of ovary Skeletal muscle satellite stem cell Muscle cell Thymic fibroblast type 1 Adipocyte Alveolar adventitial fibroblast Blood vessel smooth muscle cell Tendon cell Theca cell Thymic fibroblast type 2 Hepatic stellate cell Myometrial cell Bronchial smooth muscle cell Mesenchymal stem cell of adipose tissue Mueller cell Adventitial cell Pancreatic stellate cell Fibroblast of cardiac tissue Tongue muscle cell Connective tissue cell Fast muscle cell Fibroblast of breast Ventricular cardiac muscle cell

Vasculature Skin of body Trachea Cardiac ventricle Chorioretinal region Myometrium Brown adipose tissue Left coronary artery Lacrimal gland Stomach Ascending colon Endometrium Sigmoid colon Lung Crista ampullaris Bladder organ Aorta Subcutaneous adipose tissue Mesenteric lymph node Liver Mucosa of stomach Conjunctiva Exocrine pancreas Ileum Stomach smooth muscle Right cardiac atrium Muscle of abdomen Cornea Inferior vena cava Right ovary Prostate gland Skin of chest Abdominal aorta Large intestine Bone marrow Sclera Cardiac atrium Tongue Posterior part of tongue Sublingual gland Adipose tissue Eyelid Ovary Spleen Anterior part of tongue Thoracic aorta Uterus Muscle of pelvic diaphragm Small intestine Muscularis mucosae of stomach Thymus Left ovary Ocular surface region Buccal mucosa Posterior segment of eyeball Heart Skin of abdomen Retinal neural layer Jejunum Heart right ventricle Anterior segment of eyeball Coronary artery Duodenum Parotid gland Mammary gland Submandibular gland Testis Inguinal lymph node Lymph node Endocrine pancreas Eye Utricle of membranous labyrinth

74-year-old stage 26-year-old stage 61-year-old stage 57-year-old stage 36-year-old stage 40-year-old stage 38-year-old stage 45-year-old stage 59-year-old stage 55-year-old stage 33-year-old stage 69-year-old stage 60-year-old stage 56-year-old stage 37-year-old stage 46-year-old stage 67-year-old stage

Normal

Female Male

10x 3' v3 Smart-seq3 10x 5' v2 Smart-seq2

Cell