Homo sapiens

Megakaryocyte Natural killer cell Late pro-b cell Granulocyte monocyte progenitor cell Cd14-positive monocyte Erythroid progenitor cell Promonocyte Common myeloid progenitor Megakaryocyte-erythroid progenitor cell Naive thymus-derived cd8-positive, alpha-beta t cell Naive thymus-derived cd4-positive, alpha-beta t cell Dendritic cell Hematopoietic multipotent progenitor cell T cell Central memory cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta memory t cell Mature b cell Plasmacytoid dendritic cell, human Stromal cell of bone marrow Large pre-b-ii cell Cd16-negative, cd56-bright natural killer cell, human Small pre-b-ii cell Pro-b cell Basophilic erythroblast Common lymphoid progenitor Conventional dendritic cell Plasma cell Basophil mast progenitor cell Central memory cd8-positive, alpha-beta t cell Effector memory cd4-positive, alpha-beta t cell Hematopoietic oligopotent progenitor cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Orthochromatic erythroblast Megakaryocyte progenitor cell Polychromatophilic erythroblast Cd14-positive, cd16-positive monocyte Effector memory cd8-positive, alpha-beta t cell Pre-conventional dendritic cell Immature b cell Hematopoietic stem cell

Bone marrow

26-year-old stage 50-year-old stage 52-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage 29-year-old stage 58-year-old stage 24-year-old stage Late adult stage 84-year-old stage 31-year-old stage 59-year-old stage 66-year-old stage 57-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 47-year-old stage 36-year-old stage 32-year-old stage 67-year-old stage Young adult stage 60-year-old stage 19-year-old stage 39-year-old stage 28-year-old stage Prime adult stage 30-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3

Cell

Mus musculus

Neutrophil Macrophage T cell Hepatocyte Hepatic stellate cell Plasmacytoid dendritic cell Endothelial cell Cholangiocyte B cell Hepatic portal fibroblast

Normal

10x 3' v3

Homo sapiens

Regulatory t cell Group 3 innate lymphoid cell Naive thymus-derived cd8-positive, alpha-beta t cell T-helper 17 cell Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta memory t cell Cd16-negative, cd56-bright natural killer cell, human Cycling t cell Mucosal invariant t cell Cd16-positive, cd56-dim natural killer cell, human T follicular helper cell Effector memory cd8-positive, alpha-beta t cell

Ascending colon Body of stomach Buccal mucosa Caecum Colon Colonic epithelium Colonic mucosa Descending colon Duodenal epithelium Duodenum Epithelium of esophagus Epithelium of rectum Epithelium of small intestine Epithelium of stomach Esophagus Gingiva Ileal epithelium Ileum Ileum lamina propria Intestine Jejunum Labial gland Lamina propria of mucosa of colon Lamina propria of small intestine Mesenteric lymph node Parotid gland Periodontium Pyloric antrum Pylorus Rectosigmoid junction Rectum Sigmoid colon Small intestine Stomach Transverse colon Vermiform appendix

85-year-old stage 6-year-old stage 80-year-old stage 15th week post-fertilization stage 26-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 43-year-old stage 41-year-old stage 2-month-old stage 35-year-old stage Fifth decade stage 14-year-old stage 63-year-old stage 5-year-old stage 37-year-old stage 11th week post-fertilization stage Juvenile stage (5-14 yo) 29-year-old stage 58-year-old stage 24-year-old stage 21st week post-fertilization stage Adult stage 22-year-old stage 75-year-old stage 84-year-old stage 34-year-old stage Pediatric stage 31-year-old stage 86-year-old stage 59-year-old stage 54-year-old stage 9-year-old stage 9th week post-fertilization stage 13th week post-fertilization stage 12-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 11-year-old stage 2-year-old stage 74-year-old stage Eighth decade stage 19th week post-fertilization stage 21-year-old stage Carnegie stage 22 Fourth decade stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage Seventh decade stage 32-year-old stage 12th week post-fertilization stage 45-year-old stage 10th week post-fertilization stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 4-year-old stage Newborn stage (0-28 days) 17th week post-fertilization stage 16th week post-fertilization stage 13-year-old stage 87-year-old stage Young adult stage 60-year-old stage 62-year-old stage Sixth decade stage 10-year-old stage 39-year-old stage Carnegie stage 19 28-year-old stage Prime adult stage 23-year-old stage 30-year-old stage 18th week post-fertilization stage 72-year-old stage Carnegie stage 17 48-year-old stage 51-year-old stage 33-year-old stage Third decade stage

Normal Colorectal cancer Ulcerative colitis Crohn disease Inflammatory bowel disease Gastric cancer

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling 10x 5' v2 10x 3' v1 10x 5' v1

Cell

Mus musculus

Monocyte Granulocyte Central nervous system macrophage Osteoclast Conventional dendritic cell Kupffer cell Microglial cell Plasmacytoid dendritic cell Adipose macrophage Myeloid suppressor cell Hematopoietic stem cell

Embryo

Theiler stage 26 Theiler stage 16 Theiler stage 13 Theiler stage 14 Theiler stage 19 Theiler stage 25 Theiler stage 23 Theiler stage 17 Theiler stage 27 Theiler stage 20 Theiler stage 22 Theiler stage 12 Theiler stage 24 Theiler stage 21 Theiler stage 15 Theiler stage 18

Normal

Female Male

Sci-rna-seq3

Nucleus

Callithrix jacchus

Oligodendrocyte

Brodmann (1909) area 23 Brodmann (1909) area 25 Amygdala Anterior hypothalamic region Basal forebrain Brainstem Caudate nucleus Central amygdaloid nucleus Cerebellum lobule Dorsal thalamus Dorsolateral prefrontal cortex Hippocampal formation Lateral amygdaloid nucleus Lateral geniculate body Lateral nuclear group of thalamus Medial amygdaloid nucleus Medial dorsal nucleus of thalamus Nucleus accumbens Parietal cortex Posterior hypothalamic region Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Putamen Secondary visual cortex Temporal cortex Temporal lobe Thalamic complex Ventral lateral nucleus of thalamus Ventral thalamus

Prime adult stage Late adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Inflammatory macrophage Dendritic cell, human Non-classical monocyte Natural killer cell Neutrophil Classical monocyte Centrilobular region hepatocyte Midzonal region hepatocyte Leukocyte Fibroblast Macrophage Periportal region hepatocyte Endothelial cell of pericentral hepatic sinusoid Cd16-negative, cd56-bright natural killer cell, human Hepatic stellate cell Conventional dendritic cell Plasma cell Endothelial cell of periportal hepatic sinusoid Mucosal invariant t cell Plasmacytoid dendritic cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Cholangiocyte Cd4-positive, alpha-beta t cell Cd16-positive, cd56-dim natural killer cell, human Effector memory cd8-positive, alpha-beta t cell B cell

Caudate lobe of liver Liver

64-year-old stage 26-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 41-year-old stage 58-year-old stage 73-year-old stage Adult stage 75-year-old stage 34-year-old stage 49-year-old stage 66-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage Young adult stage 28-year-old stage Prime adult stage 72-year-old stage

Normal

Female Male

Cel-seq2 10x 3' v2 10x 3' v3

Cell Nucleus

Mus musculus

Oligodendrocyte Neural stem cell Pericyte Leptomeningeal cell Oligodendrocyte precursor cell Microglial cell Endothelial cell Astrocyte

Anterior cerebral artery Anterior olfactory nucleus Caudate-putamen Cerebral cortex Dentate gyrus of hippocampal formation Hippocampal field Lateral septal complex Nucleus accumbens Olfactory cortex Orbitofrontal cortex Pallidum Piriform cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Secondary somatosensory cortex

Prime adult stage

Normal

Male

Scatac-seq

Nucleus

Homo sapiens

Natural killer cell Neutrophil Mast cell Fibroblast Monocyte Macrophage Dendritic cell T cell Plasma cell Endothelial cell Smooth muscle cell B cell

Carotid artery segment Coronary artery Femoral artery

80-year-old stage 64-year-old stage 65-year-old stage 82-year-old stage 58-year-old stage 75-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 74-year-old stage 83-year-old stage 89-year-old stage 46-year-old stage 77-year-old stage 78-year-old stage 81-year-old stage 76-year-old stage 67-year-old stage 87-year-old stage 62-year-old stage 79-year-old stage 71-year-old stage

Atherosclerosis

Female Male

10x 3' v2 10x 3' v3

Cell

Homo sapiens

Oligodendrocyte Erythrocyte Neuroblast (sensu vertebrata) Fibroblast Neuroplacodal cell Macrophage Neural crest cell Neuron Glioblast Cell Radial glial cell Neuroblast (sensu nematoda and protostomia)

Cerebellar peduncular complex Midbrain Midbrain tectum

15th week post-fertilization stage Carnegie stage 15 9th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 16 Carnegie stage 20

Normal

10x 3' v2 10x 3' v3

Cell

Homo sapiens

Megakaryocyte Natural killer cell Epithelial cell of thymus Erythrocyte Naive b cell Cd8-positive, alpha-beta t cell Medullary thymic epithelial cell Regulatory t cell Mast cell Vascular associated smooth muscle cell Fibroblast Progenitor cell Monocyte Cortical thymic epithelial cell Alpha-beta t cell Group 3 innate lymphoid cell Memory b cell Precursor b cell Double negative thymocyte Macrophage Gamma-delta t cell Dendritic cell T cell Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta memory t cell Lymphocyte Plasma cell Double-positive, alpha-beta thymocyte Early t lineage precursor Plasmacytoid dendritic cell Endothelial cell Cd4-positive, alpha-beta t cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell

Thymus

15th week post-fertilization stage 15-month-old stage 11th week post-fertilization stage Juvenile stage (5-14 yo) 9th week post-fertilization stage 13th week post-fertilization stage 2-year-old stage Fourth decade stage 10-month-old stage 12th week post-fertilization stage 10th week post-fertilization stage 6-month-old stage 17th week post-fertilization stage 16th week post-fertilization stage 3-month-old stage Organogenesis stage Third decade stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' v1

Cell

Homo sapiens

Epithelial cell Conjunctival epithelial cell

Cornea Corneal epithelium Corneo-scleral junction Ocular surface region Sclera Substantia propria of cornea Tunica fibrosa of eyeball

64-year-old stage 65-year-old stage 43-year-old stage 41-year-old stage 90 year-old and over stage 22-year-old stage 75-year-old stage 84-year-old stage 34-year-old stage 86-year-old stage 25-year-old stage 61-year-old stage 11-year-old stage 2-year-old stage 74-year-old stage Eighth decade stage 1-year-old stage 83-year-old stage 53-year-old stage 55-year-old stage 77-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage Newborn stage (0-28 days) Postnatal stage 13-year-old stage 87-year-old stage 62-year-old stage 16-year-old stage 10-year-old stage 39-year-old stage 72-year-old stage 27-year-old stage 48-year-old stage 51-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3

Cell

Homo sapiens

Naive b cell Igg plasma cell Memory b cell Precursor b cell Plasmablast Pro-b cell Germinal center b cell Iga plasma cell Igm plasma cell

Ascending colon Body of stomach Buccal mucosa Caecum Colon Colonic epithelium Colonic mucosa Descending colon Duodenal epithelium Duodenum Epithelium of esophagus Epithelium of rectum Epithelium of small intestine Epithelium of stomach Esophagus Gingiva Ileal epithelium Ileum Ileum lamina propria Intestine Jejunum Labial gland Lamina propria of mucosa of colon Mesenteric lymph node Parotid gland Periodontium Pyloric antrum Pylorus Rectosigmoid junction Rectum Sigmoid colon Small intestine Stomach Transverse colon Vermiform appendix

85-year-old stage 6-year-old stage 80-year-old stage 15th week post-fertilization stage 26-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 43-year-old stage 41-year-old stage 2-month-old stage 35-year-old stage Fifth decade stage 14-year-old stage 63-year-old stage 5-year-old stage 37-year-old stage 11th week post-fertilization stage Juvenile stage (5-14 yo) 29-year-old stage 58-year-old stage 24-year-old stage Adult stage 75-year-old stage 84-year-old stage 34-year-old stage Pediatric stage 31-year-old stage 86-year-old stage 59-year-old stage 54-year-old stage 9-year-old stage 9th week post-fertilization stage 13th week post-fertilization stage 12-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 11-year-old stage 2-year-old stage 74-year-old stage Eighth decade stage 19th week post-fertilization stage 21-year-old stage Fourth decade stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage Seventh decade stage 32-year-old stage 12th week post-fertilization stage 45-year-old stage 10th week post-fertilization stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 4-year-old stage Newborn stage (0-28 days) 17th week post-fertilization stage 16th week post-fertilization stage 13-year-old stage Young adult stage 60-year-old stage 62-year-old stage Sixth decade stage 10-year-old stage 39-year-old stage 28-year-old stage Prime adult stage 23-year-old stage 30-year-old stage 18th week post-fertilization stage 72-year-old stage 48-year-old stage 51-year-old stage 33-year-old stage Third decade stage

Normal Colorectal cancer Ulcerative colitis Crohn disease Inflammatory bowel disease Gastric cancer

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling 10x 5' v2 10x 3' v1 10x 5' v1

Cell