Mus musculus

Migratory dendritic cell Natural killer cell Schwann cell Neutrophil Cd8-positive, alpha-beta t cell Mast cell Basal-myoepithelial cell of mammary gland Myeloid leukocyte Luminal hormone-sensing cell of mammary gland Macrophage Lactocyte Fibroblast of mammary gland Luminal adaptive secretory precursor cell of mammary gland Mammary gland epithelial cell Blood vessel endothelial cell Perivascular cell Conventional dendritic cell Cycling t cell Plasma cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Plasmacytoid dendritic cell Innate lymphoid cell Cd4-positive, alpha-beta t cell B cell

Mammary gland

10-month-old stage 7-month-old stage 3-month-old stage 11-month-old stage 8-month-old stage 13-month-old stage 9-month-old stage 12-month-old stage 18-month-old stage

Normal Neoplasm

Female

10x 3' v2 10x 3' v3

Cell

Mus musculus

Mature nk t cell Neutrophil Endothelial cell of lymphatic vessel Mast cell Monocyte Pericyte Macrophage Dendritic cell T cell Mesothelial cell Mammary gland epithelial cell Adipocyte Epithelial cell Preadipocyte Endothelial cell Smooth muscle cell B cell

Inguinal fat pad Epididymal fat pad Periovarian fat pad

19-week-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte Interneuron Mast cell Fibroblast Pericyte Macrophage T cell Ependymal cell Oligodendrocyte precursor cell Microglial cell Neuron Endothelial cell B cell Choroid plexus epithelial cell Astrocyte

Normal Alzheimer disease

10x 3' v3

Homo sapiens

Inflammatory macrophage Natural killer cell Schwann cell Endothelial cell of lymphatic vessel Regulatory t cell Mast cell Helper t cell Pericyte Endothelial cell of vascular tree Monocyte-derived dendritic cell Macrophage Dendritic cell Cytotoxic t cell Langerhans cell Conventional dendritic cell Plasma cell Skin fibroblast Innate lymphoid cell Keratinocyte Melanocyte

Dermis Skin epidermis

Adult stage

Normal

Female

10x 3' v2

Cell

Homo sapiens

Endothelial cell of lymphatic vessel Capillary endothelial cell Pericyte Mesothelial cell Vein endothelial cell Endothelial cell Smooth muscle cell Endothelial cell of artery

Heart left ventricle Apex of heart Heart right ventricle Right cardiac atrium Interventricular septum Left cardiac atrium

Fifth decade stage Eighth decade stage Seventh decade stage Sixth decade stage

Normal

Female Male

10x 3' v2 10x 3' v3

Cell Nucleus

Homo sapiens

Dendritic cell, human Non-classical monocyte Natural killer cell Classical monocyte Endothelial cell of lymphatic vessel Kidney interstitial fibroblast Vascular associated smooth muscle cell Mural cell Peritubular capillary endothelial cell Kidney loop of henle thin ascending limb epithelial cell Kidney collecting duct intercalated cell Renal medullary fibroblast Epithelial cell of proximal tubule Kidney collecting duct principal cell T cell Kidney loop of henle thick ascending limb epithelial cell Myeloid cell Parietal epithelial cell Kidney distal convoluted tubule epithelial cell Kidney inner medulla collecting duct epithelial cell Lymphocyte Conventional dendritic cell Vasa recta cell Kidney connecting tubule epithelial cell Kidney arterial blood vessel cell Kidney loop of henle thin descending limb epithelial cell B cell Podocyte Glomerular capillary endothelial cell

Kidney Renal medulla Renal papilla Cortex of kidney Renal pelvis

64-year-old stage 50-year-old stage 52-year-old stage 68-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage 63-year-old stage 29-year-old stage 58-year-old stage 31-year-old stage 42-year-old stage 49-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage Eighth decade stage 53-year-old stage 46-year-old stage 56-year-old stage 44-year-old stage Seventh decade stage 47-year-old stage 45-year-old stage 70-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 60-year-old stage 62-year-old stage 39-year-old stage 30-year-old stage 72-year-old stage 48-year-old stage 71-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' v1

Nucleus Cell

Mus musculus

Mature nk t cell Endocardial cell Natural killer cell Schwann cell Neutrophil Pancreatic a cell Type b pancreatic cell Exocrine cell Fibroblast Monocyte Pericyte Macrophage Pancreatic d cell Dendritic cell T cell Granulocyte Hepatocyte Hepatic stellate cell Kupffer cell Circulating fibrocyte Cardiac muscle cell Pancreatic pp cell Endothelial cell B cell Kidney tubule cell

Liver Kidney Pancreas Heart Blood

2-month-old stage

Normal Myocardial infarction

Male

10x 3' v3

Cell

Homo sapiens

Pulmonary artery endothelial cell Megakaryocyte Natural killer cell Erythrocyte Naive b cell Endothelial cell of lymphatic vessel Pulmonary alveolar type 1 cell Regulatory t cell Mast cell Myoepithelial cell Smooth muscle cell of the pulmonary artery Fibroblast Cd14-positive monocyte Monocyte Igg plasma cell Club cell Metallothionein-positive alveolar macrophage Myelinating schwann cell Deuterosomal cell Memory b cell Ciliated cell Effector cd4-positive, alpha-beta t cell Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Dendritic cell Mesothelial cell Non-myelinating schwann cell Plasmablast Bronchus fibroblast of lung Vein endothelial cell Blood vessel smooth muscle cell Lung interstitial macrophage Airway submucosal gland duct basal cell Epithelial cell Lung resident memory cd8-positive, alpha-beta t cell Blood vessel endothelial cell Conventional dendritic cell Lung macrophage Pulmonary alveolar type 2 cell Lung pericyte Iga plasma cell Alveolar macrophage Lung perichondrial fibroblast Mucosal invariant t cell Goblet cell Myofibroblast cell Serous secreting cell of bronchus submucosal gland Plasmacytoid dendritic cell Fibroblast of lung Neuroendocrine cell Innate lymphoid cell Chondrocyte Smooth muscle cell Effector memory cd8-positive, alpha-beta t cell Endothelial cell of artery Adventitial cell Lung resident memory cd4-positive, alpha-beta t cell Respiratory tract suprabasal cell Basal cell Lung secretory cell

Trachea Bronchus Upper lobe of left lung Lung Lower lobe of left lung

64-year-old stage 35-year-old stage 29-year-old stage 58-year-old stage 75-year-old stage 59-year-old stage 66-year-old stage Seventh decade stage Sixth decade stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling

Cell Nucleus

Mus musculus

Neutrophil Sensory neuron of dorsal root ganglion Fibroblast Pericyte Connective tissue cell Macrophage Glial cell Endothelial cell Smooth muscle cell B cell

Dorsal root ganglion

8-week-old stage 15-month-old stage

Normal Peripheral neuropathy

Female Male

10x 3' v2 10x 3' v3 Smart-seq3 Indrop Smart-seq2 10x multiome

Nucleus Cell

Homo sapiens

Adipocyte of epicardial fat of left ventricle Mast cell Pericyte Lymphoid lineage restricted progenitor cell Neuronal receptor cell Immature innate lymphoid cell Cardiac muscle myoblast Smooth muscle myoblast Fibroblast of cardiac tissue Cardiac endothelial cell

Heart left ventricle

64-year-old stage 52-year-old stage 43-year-old stage 63-year-old stage 58-year-old stage 59-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 55-year-old stage 44-year-old stage 47-year-old stage 40-year-old stage 60-year-old stage 38-year-old stage 51-year-old stage

Normal Myocardial infarction

Female Male

10x 3' v3

Nucleus

Homo sapiens

Dendritic cell, human Naive b cell Transitional stage b cell Mast cell Fibroblast Naive thymus-derived cd8-positive, alpha-beta t cell Naive thymus-derived cd4-positive, alpha-beta t cell Macrophage Gamma-delta t cell Cd14-low, cd16-positive monocyte Lymph node macrophage Marginal zone b cell of lymph node Plasmacytoid dendritic cell, human Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Double negative memory b cell Germinal center b cell Plasma cell Group 3 innate lymphoid cell, human Cd4-positive, cd25-positive, alpha-beta regulatory t cell Cd4-positive, alpha-beta memory t cell, cd45ro-positive Mucosal invariant t cell Granzyme k-associated cd8 t cell Cd16-positive, cd56-dim natural killer cell, human T follicular helper cell Naive regulatory t cell Cd14-positive, cd16-low monocyte

Axillary lymph node

50-year-old stage 41-year-old stage 35-year-old stage 24-year-old stage 22-year-old stage 34-year-old stage 21-year-old stage 32-year-old stage 40-year-old stage 19-year-old stage 38-year-old stage 27-year-old stage

Normal

Female Male

10x 5' v2

Cell

Homo sapiens

Ovarian surface epithelial cell Granulosa cell Interstitial cell of ovary Sertoli cell Leydig cell Mesothelial cell Supporting cell Mesenchymal cell

Gonad

15th week post-fertilization stage Carnegie stage 21 11th week post-fertilization stage 21st week post-fertilization stage 14th week post-fertilization stage Carnegie stage 18 9th week post-fertilization stage 13th week post-fertilization stage Carnegie stage 23 19th week post-fertilization stage 12th week post-fertilization stage 10th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 19 18th week post-fertilization stage Carnegie stage 17

Normal

Female Male

10x 5' v1

Cell