Homo sapiens

Oligodendrocyte Natural killer cell Schwann cell Vascular associated smooth muscle cell Fibroblast Pericyte Myelinating schwann cell Macrophage T cell Pigmented epithelial cell Oligodendrocyte precursor cell Microglial cell Endothelial cell B cell Melanocyte Astrocyte

Cranial nerve ii Macula lutea Optic disc Peripheral region of retina Pigmented layer of retina Sclera

50-year-old stage 65-year-old stage 74-year-old stage 53-year-old stage 77-year-old stage 47-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 30-year-old stage 72-year-old stage 71-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte Natural killer cell Schwann cell Vascular associated smooth muscle cell Fibroblast Pericyte Myelinating schwann cell Macrophage T cell Pigmented epithelial cell Oligodendrocyte precursor cell Microglial cell B cell Melanocyte Astrocyte

Normal

10x 3' v1

Homo sapiens

Oligodendrocyte L6b glutamatergic cortical neuron Near-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Sst gabaergic interneuron Cerebral cortex endothelial cell Lamp5 gabaergic interneuron Pvalb gabaergic interneuron Oligodendrocyte precursor cell Sncg gabaergic interneuron Microglial cell Caudal ganglionic eminence derived interneuron Corticothalamic-projecting glutamatergic cortical neuron Astrocyte of the cerebral cortex L2/3-6 intratelencephalic projecting glutamatergic neuron Pvalb chandelier gabaergic interneuron Vip gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron

Primary auditory cortex

50-year-old stage 43-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte Glioblast

Basal forebrain Brain Caudate-putamen Cerebellar peduncular complex Cerebellum Cerebral subcortex Cortex Diencephalon Dorsal plus ventral thalamus Entorhinal cortex Forebrain Frontal cortex Hindbrain Hippocampal formation Hypothalamus Lower layers of the cortex Medulla oblongata Metencephalon Midbrain Midbrain tectum Occipital cortex Pons Striatum Telencephalon Upper layers of the cortex

15th week post-fertilization stage 11th week post-fertilization stage Carnegie stage 15 14th week post-fertilization stage Carnegie stage 18 9th week post-fertilization stage 13th week post-fertilization stage Carnegie stage 22 12th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 16 Carnegie stage 20

Normal

10x 3' v2 10x 3' v3

Cell

Danio rerio

Fast muscle myoblast Slow muscle cell Slow muscle myoblast Fast muscle cell

Fast muscle tissue Multicellular anatomical structure Pharyngeal arch Slow muscle tissue

Pharyngula:high-pec Pharyngula:prim-5 Segmentation:20-25 somites Larval:protruding-mouth Segmentation:14-19 somites Pharyngula:prim-25 Pharyngula:prim-15 Hatching:long-pec Segmentation:26+ somites Hatching:pec-fin

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

Unipolar brush cell Cerebellar granule cell Neuron

Brodmann (1909) area 19 Brodmann (1909) area 38 Anterior nuclear group Basolateral amygdaloid nuclear complex Bed nucleus of stria terminalis Body of caudate nucleus Central amygdaloid nucleus Cerebellar nuclear complex Cerebellar vermis Cerebrocerebellum Corticomedial nuclear complex Dentate gyrus of hippocampal formation Dorsal tegmental nucleus Epithalamus Globus pallidus Gray matter of midbrain Hippocampal field Hypothalamus Inferior olivary complex Intralaminar nuclear group Lateral entorhinal cortex Lateral geniculate body Lateral nuclear group of thalamus Lateral posterior nucleus of thalamus Mammillary body Medial dorsal nucleus of thalamus Medial entorhinal cortex Medial geniculate body Medial zone of hypothalamus Midbrain nucleus Midbrain tectum Middle temporal gyrus Nucleus of medulla oblongata Parabrachial nucleus Pontine nuclear group Pontine reticular formation Pontine tegmentum Posterior parahippocampal gyrus Pretectal region Primary motor cortex Pulvinar nucleus Red nucleus Retrosplenial region Septal nuclear complex Spinal cord Substantia innominata Substantia nigra Temporal fusiform gyrus

50-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Mature nk t cell Erythrocyte Cd8-positive, alpha-beta t cell Follicular dendritic cell Regulatory t cell Malignant cell Naive thymus-derived cd8-positive, alpha-beta t cell Naive thymus-derived cd4-positive, alpha-beta t cell T cell Myeloid cell Exhausted t cell Plasma cell Cd4-positive, alpha-beta cytotoxic t cell Plasmacytoid dendritic cell Cd4-positive, alpha-beta t cell T follicular helper cell Effector cd8-positive, alpha-beta t cell B cell

Lymph node

Normal Follicular lymphoma

10x 5' v1

Cell

Macaca mulatta

Astrocyte

Brodmann (1909) area 19 Amygdala Anterior cingulate cortex Cerebellar vermis Cerebrocerebellum Corpus callosum Dorsolateral prefrontal cortex Entorhinal cortex Head of caudate nucleus Hippocampal formation Inferior parietal cortex Inferior temporal gyrus Lateral geniculate body Medial dorsal nucleus of thalamus Medulla oblongata Midbrain Nucleus accumbens Perirhinal cortex Pons Prefrontal cortex Primary auditory cortex Primary motor cortex Primary somatosensory cortex Primary visual cortex Superior parietal cortex Superior temporal sulcus Ventral lateral nucleus of thalamus

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Oligodendrocyte Vascular associated smooth muscle cell Fibroblast Monocyte Pericyte Macrophage Neoplastic cell Lymphocyte Oligodendrocyte precursor cell Microglial cell Endothelial cell B cell Astrocyte

Right temporal lobe

73-year-old stage

Glioblastoma

Male

10x 3' v3

Cell

Homo sapiens

Oligodendrocyte L6b glutamatergic cortical neuron Near-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Sst gabaergic interneuron Cerebral cortex endothelial cell Lamp5 gabaergic interneuron Pvalb gabaergic interneuron Oligodendrocyte precursor cell Sncg gabaergic interneuron Microglial cell Caudal ganglionic eminence derived interneuron Corticothalamic-projecting glutamatergic cortical neuron Astrocyte of the cerebral cortex L2/3-6 intratelencephalic projecting glutamatergic neuron Pvalb chandelier gabaergic interneuron Vip gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron

Anterior cingulate cortex

50-year-old stage 43-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Megakaryocyte Natural killer cell Granulocyte monocyte progenitor cell Fraction a pre-pro b cell Mast cell Fibroblast Monocyte Common myeloid progenitor Megakaryocyte-erythroid progenitor cell Precursor b cell Pro-t cell Macrophage Hematopoietic multipotent progenitor cell Mononuclear phagocyte Common dendritic progenitor Hepatocyte Erythroid lineage cell Pro-b cell Common lymphoid progenitor Conventional dendritic cell Kupffer cell Multi fate stem cell Stem cell Plasmacytoid dendritic cell Endothelial cell Innate lymphoid cell Neutrophilic myeloblast B cell

Metanephros Liver Zone of skin Yolk sac

15th week post-fertilization stage 11th week post-fertilization stage 14th week post-fertilization stage 9th week post-fertilization stage 13th week post-fertilization stage Carnegie stage 14 Carnegie stage 23 Carnegie stage 22 12th week post-fertilization stage 10th week post-fertilization stage 17th week post-fertilization stage 18th week post-fertilization stage

Normal

Female Male

10x genomics v2

Homo sapiens

Natural killer cell Cd8-positive, alpha-beta t cell Mast cell Monocyte Naive thymus-derived cd4-positive, alpha-beta t cell Macrophage Plasmacytoid dendritic cell, human Myeloid cell Conventional dendritic cell Cycling t cell Plasma cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell T follicular helper cell B cell

Alveolar ridge of mandible Buccal mucosa Gingiva of lower jaw Hypopharynx Larynx Mandible Mouth floor Oral cavity Oropharynx Tongue

80-year-old stage 64-year-old stage 50-year-old stage 65-year-old stage 43-year-old stage 35-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 53-year-old stage 56-year-old stage 55-year-old stage 77-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage 60-year-old stage 62-year-old stage 18-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage

Head and neck squamous cell carcinoma

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling

Cell