Homo sapiens

Natural killer cell Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Cd16-negative, cd56-bright natural killer cell, human

Blood

34-year-old stage 65-year-old stage 26-year-old stage 61-year-old stage 30-year-old stage 29-year-old stage 56-year-old stage 55-year-old stage 28-year-old stage 57-year-old stage 12-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 25-year-old stage 32-year-old stage 33-year-old stage 64-year-old stage 62-year-old stage 60-year-old stage 31-year-old stage 36-year-old stage 63-year-old stage 11-year-old stage 27-year-old stage

Cytomegalovirus infection Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Middle temporal gyrus

42-year-old stage 43-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Oligodendrocyte precursor cell Vascular leptomeningeal cell Lymphocyte Smooth muscle cell of the brain vasculature Ependymal cell Microglial cell Brain microvascular endothelial cell Pericyte Neuron Perivascular macrophage Astrocyte

Prion disease Normal

10x 3' transcription profiling

Mus musculus

Type 5b cone bipolar cell Type 1 cone bipolar cell (sensu mus) Type 6 cone bipolar cell (sensu mus) Type 5 cone bipolar cell (sensu mus) Type 3a cone bipolar cell Type 7 cone bipolar cell (sensu mus) Type 8 cone bipolar cell (sensu mus) Rod bipolar cell Type 2 cone bipolar cell (sensu mus) Type 3b cone bipolar cell Type 4 cone bipolar cell (sensu mus) Type 5a cone bipolar cell Type 9 cone bipolar cell (sensu mus)

Retina

5-week-old stage 9-week-old stage 4-month-old stage 12-week-old stage 25-week-old stage 11-week-old stage 7-week-old stage 2-week-old stage 8-week-old stage

Normal

Male

10x 3' v3 Drop-seq 10x 3' v2

Cell

Mus musculus

Type 5b cone bipolar cell Type 1 cone bipolar cell (sensu mus) Type 6 cone bipolar cell (sensu mus) Type 5 cone bipolar cell (sensu mus) Type 3a cone bipolar cell Type 7 cone bipolar cell (sensu mus) Type 8 cone bipolar cell (sensu mus) Rod bipolar cell Type 2 cone bipolar cell (sensu mus) Type 3b cone bipolar cell Type 4 cone bipolar cell (sensu mus) Type 5a cone bipolar cell Type 9 cone bipolar cell (sensu mus)

Normal

10x 3' v3 Drop-seq 10x 3' v2

Homo sapiens

Blood vessel endothelial cell Conjunctiva goblet cell Endothelial cell of lymphatic vessel Conjunctival epithelial cell Endothelial cell Schwann cell Melanocyte Smooth muscle cell Epithelial cell Lymphocyte Pericyte Progenitor cell Myeloid leukocyte Fibroblast Myelinating schwann cell Keratocyte Corneal endothelial cell

Cornea Sclera Corneo-scleral junction

66-year-old stage 69-year-old stage 65-year-old stage 71-year-old stage 30-year-old stage 44-year-old stage 50-year-old stage 57-year-old stage 72-year-old stage 24-year-old stage 58-year-old stage 33-year-old stage 62-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 47-year-old stage 83-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Erythrocyte Endothelial cell Mast cell Epithelial cell Macrophage Plasma cell B cell Fibroblast Dendritic cell

Pleural effusion Lung Axilla Liver Bone spine Brain Adrenal gland Lymph node

69-year-old stage 75-year-old stage 65-year-old stage 71-year-old stage 85-year-old stage 68-year-old stage 44-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 80-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 78-year-old stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage

Lung adenocarcinoma Normal Small cell lung carcinoma

Female Male

10x 3' transcription profiling 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Cultured cell

K-562

Normal

Sci-plex

Nucleus

Homo sapiens

Intestine goblet cell Natural killer cell Erythrocyte Gamma-delta t cell Type g enteroendocrine cell Mast cell Iga plasma cell Cd4-positive helper t cell Stem cell Natural t-regulatory cell Endothelial cell of artery Capillary endothelial cell Peptic cell Igg plasma cell P/d1 enteroendocrine cell Enteroendocrine cell Glandular cell of esophagus Macrophage Memory b cell Activated cd8-positive, alpha-beta t cell Parietal cell Enterocyte Vein endothelial cell Mucous neck cell of gastric gland Foveolar cell of stomach Monocyte Fibroblast Dendritic cell Memory t cell Epithelial cell of esophagus

Duodenum Ileal epithelium Epithelium of rectum Submucosal esophageal gland Body of stomach Cardia of stomach Ascending colon epithelium Esophagogastric junction Lower esophagus

66-year-old stage 69-year-old stage 34-year-old stage 42-year-old stage 43-year-old stage 53-year-old stage 54-year-old stage 68-year-old stage 48-year-old stage 29-year-old stage 56-year-old stage 55-year-old stage 50-year-old stage 51-year-old stage 57-year-old stage 74-year-old stage 80 year-old and over stage 58-year-old stage 67-year-old stage 77-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 60-year-old stage 63-year-old stage 83-year-old stage 27-year-old stage

Barrett esophagus Normal Gastric intestinal metaplasia Gastritis

Female Male

10x 3' v3 10x 3' v2

Cell

Oryctolagus cuniculus

Mononuclear cytotrophoblast cell Endocardial cell Cns neuron (sensu vertebrata) Endothelial cell Ectodermal cell Erythroid lineage cell Trophoblast cell Paraxial cell Notochordal cell Epithelial cell Neural crest cell Epithelial cell of thyroid gland Mesodermal cell Lateral mesodermal cell Surface ectodermal cell Bone marrow hematopoietic cell Epiblast cell Extraembryonic cell Migratory neural crest cell Fetal cardiomyocyte Obsolete somatic cell Neurecto-epithelial cell Vein endothelial cell Mesothelial cell of epicardium Mesenchymal cell Mesothelial cell Endodermal cell Progenitor cell Neuron Megakaryocyte-erythroid progenitor cell Embryonic cell (metazoa) Syncytiotrophoblast cell Primordial germ cell Amniocyte

Yolk sac Embryo Conceptus Extraembryonic tissue

Embryo stage

Normal

Mixed sex

10x genomics v3

Homo sapiens

Oligodendrocyte

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Mus musculus

Osteoblast Neutrophil Sustentacular cell Stromal cell Natural killer cell Gamma-delta t cell Endothelial cell Oligodendrocyte Alpha-beta t cell Mast cell Cd8-positive, alpha-beta t cell Group 2 innate lymphoid cell Serous secreting cell Basal cell Schwann cell Ionocyte Smooth muscle cell Epithelial cell Plasmacytoid dendritic cell Precursor b cell Olfactory receptor cell Group 3 innate lymphoid cell Goblet cell Tuft cell Macrophage Vomeronasal sensory neuron Plasmablast Hematopoietic stem cell Cd4-positive, alpha-beta t cell Ciliated epithelial cell B cell Pericyte Granulocyte monocyte progenitor cell Monocyte Fibroblast Osteoclast Dendritic cell Neural progenitor cell Chondrocyte

Normal Influenza

10x 3' v3