Homo sapiens

T cell Natural killer cell Gamma-delta t cell Plasmacytoid dendritic cell Cd8-positive, alpha-beta memory t cell Cd8-positive, alpha-beta cytotoxic t cell Regulatory t cell Plasma cell B cell Naive thymus-derived cd4-positive, alpha-beta t cell Memory t cell

Liver

66-year-old stage 75-year-old stage 53-year-old stage 68-year-old stage 55-year-old stage 28-year-old stage 72-year-old stage 49-year-old stage 58-year-old stage Adult stage 67-year-old stage 77-year-old stage 33-year-old stage 64-year-old stage 46-year-old stage 73-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus Cell

Homo sapiens

Periportal region hepatocyte Endothelial cell of periportal hepatic sinusoid Hepatic pit cell Centrilobular region hepatocyte Kupffer cell Midzonal region hepatocyte Hepatic stellate cell Macrophage Endothelial cell of pericentral hepatic sinusoid Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Monocyte Vascular associated smooth muscle cell Fibroblast Intrahepatic cholangiocyte

Caudate lobe of liver

Late adult stage Postnatal stage Prime adult stage Young adult stage

Primary sclerosing cholangitis Primary biliary cholangitis Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Oligodendrocyte precursor cell

Subthalamic nucleus Medial geniculate body Brodmann (1909) area 25 Lateral amygdaloid nucleus Anterior nuclear group Corticomedial nuclear complex Pontine reticular formation Temporal fusiform gyrus Brodmann (1909) area 19 Centromedian nucleus of thalamus Intralaminar nuclear group Medial dorsal nucleus of thalamus Parabrachial nucleus Primary visual cortex Claustrum of brain Inferior temporal gyrus Rostral ca3 Nucleus of medulla oblongata Red nucleus Subicular complex Pontine tegmentum Pontine nuclear group Globus pallidus Midbrain nucleus Piriform cortex Hippocampal field Lateral nuclear group of thalamus Brodmann (1909) area 13 Middle temporal gyrus Central amygdaloid nucleus Ventral anterior nucleus of thalamus Septal nuclear complex Brodmann (1909) area 35 Cerebellar nuclear complex Median tuberal portion Extrastriate cortex Epithalamus Dorsal tegmental nucleus Brodmann (1909) area 38 Lateral entorhinal cortex Supraoptic nucleus Brodmann (1909) area 32 Medial entorhinal cortex Midbrain tectum Inferior olivary complex Brodmann (1909) area 40 Inferior frontal gyrus Substantia nigra Agranular insular cortex Brodmann (1909) area 43 Nucleus accumbens Cerebrocerebellum Gray matter of midbrain Substantia innominata Anterior cortical amygdaloid nucleus Primary somatosensory cortex Brodmann (1909) area 14 Anterior olfactory nucleus Accessory basal amygdaloid nucleus Pulvinar nucleus Primary auditory cortex Hypothalamus Brodmann (1909) area 23 Primary motor cortex Brodmann (1909) area 24 Brodmann (1909) area 46 Medial zone of hypothalamus Posterior parahippocampal gyrus Basolateral amygdaloid nuclear complex Perirhinal cortex Granular insular cortex Cerebellar vermis Spinal cord Retrosplenial region Cuneus cortex Dentate gyrus of hippocampal formation Lateral posterior nucleus of thalamus Mammillary body Superior temporal gyrus Body of caudate nucleus Uncal ca1 Bed nucleus of stria terminalis Superior parietal cortex Lateral geniculate body Putamen Pretectal region Nucleus of dorsal thalamus Preoptic area

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

T cell Neutrophil Neural stem cell Natural killer cell Glutamatergic neuron Oligodendrocyte precursor cell Arachnoid barrier cell Endothelial cell Hypendymal cell Oligodendrocyte Neuroendocrine cell Vascular leptomeningeal cell Cholinergic neuron Tanycyte Dopaminergic neuron Ependymal cell Macrophage Microglial cell Immature astrocyte Olfactory ensheathing cell Choroid plexus epithelial cell B cell Pericyte Monocyte Vascular associated smooth muscle cell Astrocyte Dendritic cell Gabaergic neuron

Normal

10x 3' v2

Homo sapiens

Vip gabaergic interneuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Dopaminergic neuron Neuron

Substantia nigra pars compacta

91-year-old stage 92-year-old stage 82-year-old stage 90-year-old stage 49-year-old stage 79-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Endothelial cell Cycling stromal cell Endothelial cell of artery Capillary endothelial cell Endothelial cell of vascular tree Vein endothelial cell Pericyte Vascular associated smooth muscle cell Myofibroblast cell Fibroblast

Breast

66-year-old stage 69-year-old stage Middle aged stage 65-year-old stage 42-year-old stage 43-year-old stage Sixth decade stage 71-year-old stage 85-year-old stage 61-year-old stage 88-year-old stage 52-year-old stage 54-year-old stage 30-year-old stage 29-year-old stage 38-year-old stage Fifth decade stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 57-year-old stage 80 year-old and over stage 49-year-old stage 35-year-old stage Seventh decade stage 58-year-old stage 59-year-old stage 25-year-old stage Adult stage 67-year-old stage Late adult stage 32-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage 60-79 year-old stage 36-year-old stage 63-year-old stage Eighth decade stage 47-year-old stage 73-year-old stage 83-year-old stage Prime adult stage Ninth decade stage

Invasive ductal breast carcinoma Breast cancer Estrogen-receptor positive breast cancer Breast apocrine carcinoma Invasive lobular breast carcinoma Metaplastic breast carcinoma Her2 positive breast carcinoma Breast mucinous carcinoma Triple-negative breast carcinoma Invasive tubular breast carcinoma Breast carcinoma

Female Male

10x 5' v2 10x 5' transcription profiling 10x 5' v1 10x 3' v3 10x 3' v2

Cell

Mus musculus

Enteric neuron Peripheral nervous system neuron Sympathetic neuron Spiral ganglion neuron Parasympathetic neuron Sensory neuron of dorsal root ganglion

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 14 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 13 Theiler stage 20 Theiler stage 12 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Mus musculus

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Leptomeningeal cell Pericyte Astrocyte Gabaergic neuron Neural progenitor cell

Secondary somatosensory cortex Neocortex Lateral septal complex Piriform cortex Hippocampal field Prefrontal cortex Pallidum Orbitofrontal cortex Olfactory cortex Cerebral cortex Nucleus accumbens Primary somatosensory cortex Anterior olfactory nucleus Primary auditory cortex Primary motor cortex Caudate-putamen Dentate gyrus of hippocampal formation

8-week-old stage

Normal

Male

Snmc-seq2

Nucleus

Mus musculus

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Leptomeningeal cell Pericyte Astrocyte Gabaergic neuron Neural progenitor cell

Secondary somatosensory cortex Neocortex Lateral septal complex Piriform cortex Hippocampal field Prefrontal cortex Pallidum Orbitofrontal cortex Olfactory cortex Cerebral cortex Nucleus accumbens Primary somatosensory cortex Anterior olfactory nucleus Primary auditory cortex Primary motor cortex Caudate-putamen Dentate gyrus of hippocampal formation

8-week-old stage

Normal

Male

Snmc-seq2

Nucleus

Homo sapiens

Natural killer cell Igg memory b cell Cd8-positive, alpha-beta t cell Exhausted t cell Lymphocyte Regulatory t cell Helper t cell Plasma cell Iga memory b cell Mucosal invariant t cell B cell, cd19-positive

Left lobe of liver Right lobe of liver Caudate lobe of liver Liver

66-year-old stage 37-year-old stage 75-year-old stage 21-year-old stage 65-year-old stage 26-year-old stage Sixth decade stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 48-year-old stage 39-year-old stage 44-year-old stage 56-year-old stage Fifth decade stage 55-year-old stage 50-year-old stage 80-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage Third decade stage 49-year-old stage Seventh decade stage 59-year-old stage Adult stage 67-year-old stage Late adult stage 32-year-old stage 77-year-old stage 33-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage Fourth decade stage Eighth decade stage 73-year-old stage Prime adult stage Ninth decade stage Young adult stage

Normal

Female Male

10x 5' v1 10x 3' v3 10x 3' v2

Nucleus Cell