Homo sapiens

Ventricular cardiac muscle cell

Heart left ventricle Apex of heart

27-year-old stage 26-year-old stage 19-year-old stage Third decade stage 21-year-old stage 61-year-old stage Sixth decade stage 49-year-old stage 52-year-old stage 70-year-old stage 38-year-old stage Eighth decade stage 30-year-old stage 55-year-old stage 64-year-old stage 29-year-old stage 32-year-old stage 28-year-old stage Fifth decade stage 31-year-old stage 25-year-old stage 24-year-old stage Seventh decade stage

Myocarditis Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Iga plasma cell Fibroblast Enteroendocrine cell Transit amplifying cell Germinal center b cell Mast cell Igg plasma cell Glial cell Vein endothelial cell Intestinal tuft cell Epithelial cell Dendritic cell B cell Capillary endothelial cell Paneth cell Myofibroblast cell Plasmacytoid dendritic cell Goblet cell Igm plasma cell Endothelial cell of lymphatic vessel Macrophage Monocyte T cell Epithelial fate stem cell Endothelial cell Endothelial cell of artery

Lamina propria of small intestine

13-year-old stage 17-year-old stage 12-year-old stage 10-year-old stage 14-year-old stage 22-year-old stage 15-year-old stage 18-year-old stage 11-year-old stage 16-year-old stage

Digestive system disorder

Female Male

10x 3' v2

Cell

Homo sapiens

Iga plasma cell Fibroblast Enteroendocrine cell Transit amplifying cell Germinal center b cell Mast cell Igg plasma cell Glial cell Vein endothelial cell Intestinal tuft cell Epithelial cell Dendritic cell B cell Capillary endothelial cell Paneth cell Myofibroblast cell Plasmacytoid dendritic cell Goblet cell Igm plasma cell Endothelial cell of lymphatic vessel Macrophage Monocyte T cell Epithelial fate stem cell Endothelial cell Endothelial cell of artery

Functional colonic disease

10x 3' v2

Homo sapiens

Fibroblast Periportal region hepatocyte Kupffer cell Mast cell Vein endothelial cell Endothelial cell of periportal hepatic sinusoid Neutrophil Plasma cell Midzonal region hepatocyte Centrilobular region hepatocyte Intrahepatic cholangiocyte Hepatocyte Hepatic pit cell Plasmacytoid dendritic cell Cd8-positive, alpha-beta t cell Natural killer cell Macrophage Hepatic stellate cell Mature b cell Erythrocyte Conventional dendritic cell Monocyte Endothelial cell of pericentral hepatic sinusoid Cd4-positive, alpha-beta t cell T cell Endothelial cell of artery

Caudate lobe of liver

Postnatal stage Late adult stage Young adult stage Prime adult stage

Primary sclerosing cholangitis Primary biliary cholangitis Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Mus musculus

Regulatory t cell Activated cd4-negative, cd8-negative type i nk t cell Natural killer cell T cell

Embryo

Theiler stage 26 Theiler stage 18 Theiler stage 24 Theiler stage 14 Theiler stage 12 Theiler stage 23 Theiler stage 20 Theiler stage 22 Theiler stage 16 Theiler stage 21 Theiler stage 25 Theiler stage 27 Theiler stage 19

Normal

Female Male

Sci-rna-seq3

Nucleus

Macaca mulatta

L6b glutamatergic cortical neuron Lamp5 gabaergic interneuron Astrocyte of the cerebral cortex Corticothalamic-projecting glutamatergic cortical neuron Pvalb chandelier gabaergic interneuron Vip gabaergic interneuron Oligodendrocyte precursor cell Caudal ganglionic eminence derived interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron Oligodendrocyte Cerebral cortex endothelial cell Pvalb gabaergic interneuron Sncg gabaergic interneuron Sst gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron Near-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Microglial cell

Middle temporal gyrus

Prime adult stage

Normal

Female

10x 3' v3

Nucleus

Homo sapiens

Iga plasma cell Fibroblast Innate lymphoid cell Lung pericyte Pulmonary ionocyte Plasmablast Mucosal invariant t cell Mast cell Igg plasma cell Effector memory cd8-positive, alpha-beta t cell Cd14-low, cd16-positive monocyte Vein endothelial cell Myelinating schwann cell Cd14-positive monocyte Alveolar macrophage Smooth muscle cell Cd4-positive, alpha-beta memory t cell Tracheobronchial chondrocyte Memory b cell Gamma-delta t cell Regulatory t cell Chondrocyte Non-myelinating schwann cell Tracheobronchial smooth muscle cell Megakaryocyte Myoepithelial cell Fibroblast of lung Capillary endothelial cell Mucus secreting cell Pericyte Myofibroblast cell Club cell Respiratory tract epithelial cell Lymph node lymphatic vessel endothelial cell Pulmonary alveolar type 2 cell Plasmacytoid dendritic cell Goblet cell Respiratory basal cell Tracheobronchial serous cell Pulmonary alveolar type 1 cell Blood vessel smooth muscle cell Lung macrophage Natural killer cell Macrophage Deuterosomal cell Ciliated epithelial cell Neuroendocrine cell Erythrocyte Conventional dendritic cell Mature nk t cell Cd8-positive, alpha-beta memory t cell Mesothelial cell Simple columnar epithelial cell Cd4-positive, alpha-beta t cell Pulmonary artery endothelial cell Naive b cell Endothelial cell of artery

Trachea Lower lobe of left lung Lung Bronchus Upper lobe of left lung

75-year-old stage 64-year-old stage 29-year-old stage Post-juvenile adult stage Seventh decade stage

Normal

Male Female Mixed sex

10x genomics v2 10x genomics v3

Mus musculus

Fibroblast Smooth muscle cell Dendritic cell Pericyte Natural killer cell Macrophage Microglial cell Choroid plexus epithelial cell T cell Endothelial cell

Normal Alzheimer disease

10x 3' v3

Homo sapiens

Mast cell Stratified epithelial cell Epithelial cell Stromal cell Mononuclear phagocyte Immature b cell Dendritic cell B cell Blood vessel endothelial cell Mucus secreting cell Cd8-positive, alpha-beta t cell Endothelial cell of lymphatic vessel Epithelial cell of stratum germinativum of esophagus Cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta cytotoxic t cell

Epithelium of esophagus

Sixth decade stage Fourth decade stage Fifth decade stage Seventh decade stage

Normal

Female Male

10x 3' v2

Cell

Danio rerio

Neural progenitor cell Neuroblast (sensu vertebrata) Glial cell Glutamatergic neuron Neuron

Forebrain Ventricular zone Spinal cord Hindbrain Multicellular anatomical structure

Hatching:pec-fin Larval:protruding-mouth Pharyngula:prim-15 Pharyngula:prim-25 Segmentation:14-19 somites Pharyngula:high-pec Segmentation:26+ somites Hatching:long-pec Segmentation:20-25 somites Pharyngula:prim-5

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

Type ii muscle cell Type i muscle cell Muscle cell

Intercostal muscle

Third decade stage Sixth decade stage Fourth decade stage Eighth decade stage Young adult stage Seventh decade stage

Normal

Female Male

10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

Astrocyte of the cerebral cortex

Dorsolateral prefrontal cortex

78-year-old stage 80 year-old and over stage 72-year-old stage 83-year-old stage 85-year-old stage 81-year-old stage 82-year-old stage 42-year-old stage 86-year-old stage 70-year-old stage 75-year-old stage 50-year-old stage 89-year-old stage 68-year-old stage 29-year-old stage 77-year-old stage 69-year-old stage 88-year-old stage 87-year-old stage 80-year-old stage 84-year-old stage

Dementia Normal

Female Male

10x multiome 10x 3' v3

Nucleus