Homo sapiens

Neuron

Prefrontal cortex

66-year-old stage 89-year-old stage 87-year-old stage 71-year-old stage 61-year-old stage 68-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 67-year-old stage 62-year-old stage 79-year-old stage 73-year-old stage

Normal Alzheimer disease

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Osteoblast Neural stem cell Erythroid progenitor cell, mammalian Peridermal cell Ectodermal cell Schwann cell Melanocyte Neuroplacodal cell Neural crest cell Muscle precursor cell Epithelial cell of thyroid gland Immature innate lymphoid cell Embryonic blood vessel endothelial progenitor cell Pituitary gland cell Mesenchymal cell Progenitor cell Neural progenitor cell

Pharyngeal arch system

Carnegie stage 14 Carnegie stage 13 Carnegie stage 20 Carnegie stage 17 Carnegie stage 12 Carnegie stage 16

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell T cell Effector cd8-positive, alpha-beta t cell Activated cd4-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Regulatory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell

Blood

Sixth decade stage Fifth decade stage Seventh decade stage Fourth decade stage

Covid-19 Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Homo sapiens

Gamma-delta t cell Activated cd4-positive, alpha-beta t cell Hematopoietic precursor cell Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell Cd8-positive, alpha-beta memory t cell Naive thymus-derived cd8-positive, alpha-beta t cell Macrophage Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Memory b cell Cd16-positive, cd56-dim natural killer cell, human Regulatory t cell Activated cd8-positive, alpha-beta t cell Plasma cell Type i nk t cell Cd4-positive, alpha-beta memory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Naive b cell Conventional dendritic cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Blood

66-year-old stage 37-year-old stage 34-year-old stage 42-year-old stage 52-year-old stage 55-year-old stage 50-year-old stage 28-year-old stage 33-year-old stage 31-year-old stage 36-year-old stage 22-year-old stage

Normal Common variable immunodeficiency

Female Male

10x 5' v1

Cell

Homo sapiens

Angiogenic pericyte Muscle cell Immature pericyte Smooth muscle cell Mesodermal cell Fibroblastic reticular cell Mesenchymal cell Gastrointestinal tract (lamina propria) macrophage Mesothelial cell Vascular associated smooth muscle cell Myofibroblast cell Fibroblast

Duodenum Pyloric antrum Small intestine Ileum Colon Intestine Body of stomach Esophagus Mesenteric lymph node

19th week post-fertilization stage 21st week post-fertilization stage 15th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage 18th week post-fertilization stage 2-month-old stage Newborn stage (0-28 days)

Normal

Female Male

10x 5' v2 10x 3' v2

Cell

Homo sapiens

T cell Neutrophil Muscle cell Natural killer cell Erythrocyte Activated cd4-positive, alpha-beta t cell Endothelial cell Mature nk t cell Hematopoietic precursor cell Mast cell Cd8-positive, alpha-beta t cell Platelet Leukocyte Classical monocyte Smooth muscle cell Intermediate monocyte Myeloid dendritic cell Macrophage Plasma cell Cd4-positive, alpha-beta t cell Mesenchymal stem cell of adipose tissue B cell Pericyte Mesenchymal stem cell Monocyte Myofibroblast cell Fibroblast Non-classical monocyte

Brown adipose tissue Subcutaneous adipose tissue Adipose tissue

61-year-old stage 56-year-old stage 59-year-old stage 33-year-old stage 45-year-old stage 60-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Homo sapiens

T cell Cd8-alpha alpha positive, gamma-delta intraepithelial t cell Igm plasma cell Natural killer cell Cd8-positive, alpha-beta t cell Platelet Plasmacytoid dendritic cell Igg plasma cell Lymphocyte Macrophage Cd4-positive, cd25-positive, alpha-beta regulatory t cell Follicular b cell Innate lymphoid cell Activated cd8-positive, alpha-beta t cell Plasmablast Hematopoietic stem cell Cd4-positive, alpha-beta t cell T follicular helper cell B cell Naive thymus-derived cd4-positive, alpha-beta t cell Monocyte Conventional dendritic cell Dendritic cell

Spleen

Sixth decade stage Fifth decade stage Third decade stage

Normal

Female Male

10x 3' v2

Cell

Mus musculus

Glutamatergic neuron Gabaergic neuron

Primary motor cortex

5-week-old stage 9-week-old stage 15-week-old stage 13-week-old stage 21-week-old stage 26-week-old stage 12-week-old stage 20-week-old stage 14-week-old stage Prime adult stage 29-week-old stage 19-week-old stage 18-week-old stage 25-week-old stage 11-week-old stage 7-week-old stage 6-week-old stage 8-month-old stage 10-week-old stage 23-week-old stage 17-week-old stage 16-week-old stage 8-week-old stage

Normal

Female Male

Patch-seq 10x 3' v2

Cell

Homo sapiens

Effector cd8-positive, alpha-beta t cell Pro-t cell Endothelial cell Mature nk t cell Iga plasma cell Inflammatory macrophage Ionocyte Smooth muscle cell Alternatively activated macrophage Igg plasma cell Myoepithelial cell Cd8-positive, alpha-beta cytotoxic t cell Duct epithelial cell Acinar cell of salivary gland Cd4-positive, alpha-beta t cell B cell Cd8-positive, alpha-beta regulatory t cell Fibroblast Dendritic cell

Labial gland

75-year-old stage 65-year-old stage 43-year-old stage 53-year-old stage 61-year-old stage 54-year-old stage 48-year-old stage 39-year-old stage 38-year-old stage 56-year-old stage 55-year-old stage 50-year-old stage 51-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 45-year-old stage 47-year-old stage 40-year-old stage

Sjogren syndrome Normal

Female Male

10x 3' v3 10x 3' v2

Cell

Mus musculus

T cell Stromal cell Natural killer cell Oligodendrocyte precursor cell Gamma-delta t cell Mature nk t cell Exhausted t cell Classical monocyte Smooth muscle cell Plasmacytoid dendritic cell Effector cd4-positive, alpha-beta t cell Mature neutrophil Naive thymus-derived cd8-positive, alpha-beta t cell Macrophage Cd4-positive, cd25-positive, alpha-beta regulatory t cell Microglial cell Neoplastic cell Plasma cell Endothelial cell of high endothelial venule Choroid plexus epithelial cell B cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Neuron Astrocyte Conventional dendritic cell Fibroblast Memory t cell Effector memory cd8-positive, alpha-beta t cell

Brain

2-month-old stage

Glioblastoma

Female Male

10x 3' v3

Cell

Homo sapiens

Cardiac pacemaker cell of sinoatrial node Neutrophil Endocardial cell Dendritic cell, human T-helper 2 cell Endothelial cell of lymphatic vessel Activated cd4-positive, alpha-beta t cell Endothelial cell Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Smooth muscle cell of the pulmonary artery Atrioventricular bundle cell Adipocyte Cd8-positive, alpha-beta cytotoxic t cell Macrophage Cd16-positive, cd56-dim natural killer cell, human Innate lymphoid cell Glial cell Plasma cell Vein endothelial cell Cd14-positive monocyte Cd14-low, cd16-positive monocyte Mesothelial cell B cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell Regular atrial cardiac myocyte Monocyte Regular ventricular cardiac myocyte Fibroblast of cardiac tissue Cd16-negative, cd56-bright natural killer cell, human

Heart right ventricle Right cardiac atrium Apex of heart Sinoatrial node Heart left ventricle Left cardiac atrium Atrioventricular node Interventricular septum

Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Eighth decade stage

Normal

Female Male

Visium spatial gene expression v1

Mus musculus

Epithelial cell of pancreas Neural cell Retinal bipolar neuron Photoreceptor cell Retinal cone cell Retinal rod cell Pinealocyte Pituitary gland cell Cochlea auditory hair cell Retinal progenitor cell Iris pigment epithelial cell

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 14 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 13 Theiler stage 20 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus