Homo sapiens

T cell Neutrophil Periportal region hepatocyte Hepatocyte Endothelial cell of periportal hepatic sinusoid Natural killer cell Hepatic pit cell Erythrocyte Centrilobular region hepatocyte Kupffer cell Midzonal region hepatocyte Mast cell Cd8-positive, alpha-beta t cell Endothelial cell of artery Plasmacytoid dendritic cell Hepatic stellate cell Macrophage Endothelial cell of pericentral hepatic sinusoid Mature b cell Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Monocyte Conventional dendritic cell Fibroblast Intrahepatic cholangiocyte

Caudate lobe of liver

Late adult stage Postnatal stage Prime adult stage Young adult stage

Primary sclerosing cholangitis Primary biliary cholangitis Normal

Female Male

10x 5' v2 10x 5' v1

Cell

Mus musculus

T cell Natural killer cell Regulatory t cell Activated cd4-negative, cd8-negative type i nk t cell

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 14 Theiler stage 16 Theiler stage 19 Theiler stage 26 Theiler stage 20 Theiler stage 12 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Macaca mulatta

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Middle temporal gyrus

Prime adult stage

Normal

Female

10x 3' v3

Nucleus

Homo sapiens

Medial ganglionic eminence derived gabaergic interneuron L2/3 intratelencephalic projecting glutamatergic neuron L5/6 near-projecting glutamatergic neuron Glutamatergic neuron Oligodendrocyte precursor cell L5 intratelencephalic projecting glutamatergic neuron Oligodendrocyte Amygdala excitatory neuron Committed oligodendrocyte precursor Hippocampal ca1-3 neuron Dentate gyrus neuron Lamp5 gabaergic interneuron Brain vascular cell Microglial cell Caudal ganglionic eminence derived interneuron Astrocyte Fibroblast

Temporal cortex Frontal lobe Hippocampal formation Amygdala

15-year-old stage 9-year-old stage 14-year-old stage 11-year-old stage 6-year-old stage 10-year-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Tracheobronchial smooth muscle cell Club cell Tracheobronchial serous cell Natural killer cell Erythrocyte Non-myelinating schwann cell Gamma-delta t cell Neuroendocrine cell Mature nk t cell Mast cell Pulmonary ionocyte Iga plasma cell Blood vessel smooth muscle cell Lymph node lymphatic vessel endothelial cell Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Respiratory tract epithelial cell Plasmacytoid dendritic cell Igg plasma cell Cd8-positive, alpha-beta memory t cell Myoepithelial cell Lung macrophage Goblet cell Macrophage Memory b cell Innate lymphoid cell Regulatory t cell Deuterosomal cell Pulmonary alveolar type 1 cell Plasmablast Respiratory basal cell Simple columnar epithelial cell Fibroblast of lung Alveolar macrophage Cd4-positive, alpha-beta t cell Vein endothelial cell Cd14-positive monocyte Megakaryocyte Cd14-low, cd16-positive monocyte Cd4-positive, alpha-beta memory t cell Mesothelial cell Ciliated epithelial cell Pericyte Mucosal invariant t cell Pulmonary artery endothelial cell Tracheobronchial chondrocyte Mucus secreting cell Naive b cell Myofibroblast cell Conventional dendritic cell Fibroblast Myelinating schwann cell Pulmonary alveolar type 2 cell Effector memory cd8-positive, alpha-beta t cell Lung pericyte Chondrocyte

Bronchus Lung Trachea Upper lobe of left lung Lower lobe of left lung

75-year-old stage 29-year-old stage Seventh decade stage Post-juvenile adult stage 64-year-old stage

Normal

Male Female Mixed sex

10x genomics v2 10x genomics v3

Mus musculus

T cell Natural killer cell Endothelial cell Smooth muscle cell Macrophage Microglial cell Choroid plexus epithelial cell Pericyte Fibroblast Dendritic cell

Normal Alzheimer disease

10x 3' v3

Homo sapiens

Blood vessel endothelial cell Stromal cell Endothelial cell of lymphatic vessel Mast cell Cd8-positive, alpha-beta t cell Stratified epithelial cell Epithelial cell Cd8-positive, alpha-beta cytotoxic t cell Epithelial cell of stratum germinativum of esophagus Cd4-positive, alpha-beta t cell B cell Immature b cell Mucus secreting cell Dendritic cell Mononuclear phagocyte

Epithelium of esophagus

Sixth decade stage Fifth decade stage Seventh decade stage Fourth decade stage

Normal

Female Male

10x 3' v2

Cell

Danio rerio

Glutamatergic neuron Neuroblast (sensu vertebrata) Glial cell Neuron Neural progenitor cell

Hindbrain Ventricular zone Multicellular anatomical structure Spinal cord Forebrain

Pharyngula:prim-15 Hatching:long-pec Larval:protruding-mouth Pharyngula:prim-25 Segmentation:26+ somites Segmentation:14-19 somites Hatching:pec-fin Segmentation:20-25 somites Pharyngula:high-pec Pharyngula:prim-5

Normal

Sci-rna-seq3

Nucleus

Mus musculus

Smooth muscle cell

Aorta

15-week-old stage 13-week-old stage 24-week-old stage 20-week-old stage 17-week-old stage 8-week-old stage

Atherosclerosis

Male

10x scatac-seq

Nucleus

Homo sapiens

Muscle cell Type ii muscle cell Type i muscle cell

Intercostal muscle

Sixth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage Young adult stage

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus Cell

Homo sapiens

Astrocyte of the cerebral cortex

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Callithrix jacchus

Gabaergic neuron

Brodmann (1909) area 25 Dorsolateral prefrontal cortex Prefrontal cortex

Late adult stage Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus