Homo sapiens

Natural killer cell Cd8-positive, alpha-beta t cell Platelet Erythroid lineage cell Cd16-positive, cd56-dim natural killer cell, human Cd4-positive, alpha-beta t cell Cd14-positive monocyte B cell Dendritic cell

Blood

91-year-old stage 65-year-old stage 89-year-old stage 71-year-old stage 85-year-old stage 61-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 50-year-old stage 80-year-old stage 81-year-old stage 74-year-old stage 58-year-old stage 67-year-old stage 77-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 73-year-old stage 83-year-old stage

Clonal hematopoiesis Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Microglial cell Neuron Astrocyte

Occipital cortex

66-year-old stage 65-year-old stage 88-year-old stage 68-year-old stage 84-year-old stage 74-year-old stage 58-year-old stage 67-year-old stage 62-year-old stage 70-year-old stage 63-year-old stage 73-year-old stage 83-year-old stage 96-year-old stage

Frontotemporal dementia Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Central memory cd4-positive, alpha-beta t cell Neutrophil Erythrocyte Small pre-b-ii cell Gamma-delta t cell Mature nk t cell Pro-b cell Mast cell Effector memory cd4-positive, alpha-beta t cell Erythroid lineage cell Classical monocyte Plasmacytoid dendritic cell, human Plasmacytoid dendritic cell Early lymphoid progenitor Megakaryocyte progenitor cell Common dendritic progenitor Thymocyte Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Memory b cell Cd16-positive, cd56-dim natural killer cell, human Regulatory t cell Plasmablast Common myeloid progenitor Plasma cell Neutrophil progenitor cell Hematopoietic multipotent progenitor cell Megakaryocyte T follicular helper cell Granulocyte monocyte progenitor cell Mucosal invariant t cell Promyelocyte Megakaryocyte-erythroid progenitor cell Central memory cd8-positive, alpha-beta t cell Naive b cell Conventional dendritic cell Cd16-negative, cd56-bright natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Bone marrow

42-year-old stage Sixth decade stage 61-year-old stage 30-year-old stage 17-year-old stage Seventh decade stage 59-year-old stage 31-year-old stage 22-year-old stage Eighth decade stage

Normal

Female Male

10x 5' v2 10x 5' transcription profiling 10x 5' v1 Smart-seq2 10x 3' v3

Cell

Homo sapiens

T cell Neutrophil Bladder urothelial cell Natural killer cell Endothelial cell of lymphatic vessel Erythrocyte Endothelial cell Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Capillary endothelial cell Smooth muscle cell Macrophage Regulatory t cell Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell B cell Pericyte Monocyte Myofibroblast cell Fibroblast

Bladder organ

61-year-old stage 56-year-old stage 59-year-old stage 45-year-old stage 60-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Homo sapiens

Neutrophil Club cell Respiratory tract goblet cell Serous cell of epithelium of bronchus Natural killer cell Endothelial cell of lymphatic vessel Mature nk t cell Mast cell Pulmonary ionocyte Cd8-positive, alpha-beta t cell Basal cell Endothelial cell of artery Capillary endothelial cell Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell Myeloid dendritic cell Lung multiciliated epithelial cell Macrophage Pulmonary alveolar type 1 cell Bronchial smooth muscle cell Plasma cell Cd4-positive, alpha-beta t cell Vein endothelial cell Alveolar adventitial fibroblast Mesothelial cell B cell Pericyte Adventitial cell Monocyte Vascular associated smooth muscle cell Basophil Pulmonary alveolar type 2 cell Non-classical monocyte

Lung

61-year-old stage 59-year-old stage 60-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Mus musculus

T cell Natural killer cell Endothelial cell of lymphatic vessel Endothelial cell Epithelial cell Macrophage Mesenchymal stem cell of adipose tissue Mesothelial cell B cell Pericyte Monocyte Dendritic cell

Obesity disorder

10x 3' v3

Homo sapiens

Club cell Cd1c-positive myeloid dendritic cell Tracheobronchial serous cell Ciliated cell Natural killer cell Endothelial cell of lymphatic vessel Endothelial cell Myeloid dendritic cell, human Mature nk t cell Pulmonary ionocyte Pulmonary neuroendocrine cell Basal cell Effector memory cd4-positive, alpha-beta t cell Lung goblet cell Endothelial cell of artery Capillary endothelial cell Classical monocyte Intermediate monocyte Plasmacytoid dendritic cell, human Epithelial cell Lung multiciliated epithelial cell Lymphocyte Naive thymus-derived cd8-positive, alpha-beta t cell Mesothelial cell of pleura Macrophage Pulmonary alveolar type 1 cell Bronchial smooth muscle cell Respiratory basal cell Alveolar macrophage Plasma cell Vein endothelial cell Megakaryocyte Pulmonary interstitial fibroblast B cell Pericyte Naive thymus-derived cd4-positive, alpha-beta t cell Myeloid leukocyte Monocyte Mucus secreting cell Vascular associated smooth muscle cell Myofibroblast cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell Effector memory cd8-positive, alpha-beta t cell Non-classical monocyte

Lung Blood

75-year-old stage 51-year-old stage 46-year-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Migratory dendritic cell Kupffer cell Classical monocyte Mature neutrophil Lymphocyte Trem2-positive macrophage Monocyte Conventional dendritic cell Dendritic cell Bag3-positive monocyte Non-classical monocyte

Left lobe of liver Right lobe of liver Caudate lobe of liver Liver

66-year-old stage 37-year-old stage 75-year-old stage 21-year-old stage 65-year-old stage 26-year-old stage Sixth decade stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 54-year-old stage 48-year-old stage 39-year-old stage 44-year-old stage 56-year-old stage Fifth decade stage 55-year-old stage 50-year-old stage 80-year-old stage 28-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage Third decade stage 49-year-old stage Seventh decade stage 59-year-old stage Adult stage 67-year-old stage Late adult stage 32-year-old stage 77-year-old stage 33-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 46-year-old stage 60-year-old stage Fourth decade stage Eighth decade stage 73-year-old stage Prime adult stage Ninth decade stage Young adult stage

Normal

Female Male

10x 5' v1 10x 3' v3 10x 3' v2

Nucleus Cell

Homo sapiens

T cell Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Microglial cell Vein endothelial cell Pericyte Perivascular macrophage Astrocyte Fibroblast Gabaergic neuron

Dorsolateral prefrontal cortex

87-year-old stage 88-year-old stage 84-year-old stage 81-year-old stage 90 year-old and over stage 78-year-old stage 79-year-old stage 83-year-old stage

Cognitive disorder Normal Alzheimer disease

Female Male

10x multiome

Nucleus

Mus musculus

Blood vessel endothelial cell Microvascular endothelial cell Tendon cell Schwann cell Smooth muscle cell Lymphocyte Adipocyte Macrophage Type iib muscle cell Type iix muscle cell Fibro/adipogenic progenitor cell Perineurial cell Pericyte Skeletal muscle satellite stem cell Neuromuscular junction nucleus Myotendinous junction nucleus Type iia muscle cell Intermediate muscle cell

Gastrocnemius Skeletal muscle tissue of tibialis anterior

Prime adult stage

Lesion of sciatic nerve Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Intestinal crypt stem cell of colon Gut absorptive cell Goblet cell Tuft cell Intestinal enteroendocrine cell Neoplastic cell Intestinal epithelial cell Transit amplifying cell Abnormal cell

Ascending colon Hepatic flexure of colon Rectum Transverse colon Descending colon Sigmoid colon Hepatic cecum

65-year-old stage 71-year-old stage 53-year-old stage 54-year-old stage 68-year-old stage 50-year-old stage 57-year-old stage 72-year-old stage 58-year-old stage 59-year-old stage 67-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 60-year-old stage 73-year-old stage

Tubulovillous adenoma Tubular adenoma Colorectal neoplasm Normal Hyperplastic polyp Colon sessile serrated adenoma/polyp

Female Male

Trudrop

Cell

Homo sapiens

Fast muscle cell T cell Granulocyte Endothelial cell of venule Natural killer cell Endothelial cell of lymphatic vessel Slow muscle cell Endothelial cell of arteriole Blood vessel smooth muscle cell Skeletal muscle satellite cell Neural cell Adipocyte Macrophage Plasma cell B cell Pericyte Monocyte Fibroblast Dendritic cell Skeletal muscle fiber Chondrocyte

Calcaneal tendon

51-year-old stage 74-year-old stage 58-year-old stage 45-year-old stage 76-year-old stage

Normal

Female Male

10x 3' v3

Nucleus