Homo sapiens

L6b glutamatergic cortical neuron Astrocyte Lamp5 gabaergic interneuron Vip gabaergic interneuron Oligodendrocyte precursor cell Caudal ganglionic eminence derived interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron Oligodendrocyte L6 corticothalamic-projecting glutamatergic cortical neuron Pericyte Pvalb gabaergic interneuron Glutamatergic neuron Sst gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron Near-projecting glutamatergic cortical neuron Vascular leptomeningeal cell Microglial cell Endothelial cell

Primary motor cortex Anterior cingulate gyrus Primary visual cortex Primary somatosensory cortex Primary auditory cortex Middle temporal gyrus

54-year-old stage 50-year-old stage 43-year-old stage

Normal

Female Male

Smart-seq v4

Nucleus

Homo sapiens

Myeloid cell Cardiac endothelial cell Smooth muscle cell Cardiac muscle cell Pericyte Lymphocyte Cardiac neuron Fibroblast of cardiac tissue

Heart left ventricle Apex of heart Interventricular septum Heart right ventricle

54-year-old stage 55-year-old stage 47-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Fibroblast Neutrophil Epithelial cell Dendritic cell B cell Obsolete animal cell Eosinophil Macrophage T cell

Normal

Seq-well

Homo sapiens

Fibroblast Neutrophil Epithelial cell Dendritic cell B cell Obsolete animal cell Eosinophil Macrophage T cell

Normal

Seq-well

Homo sapiens

Plasmablast Mucosal invariant t cell Effector memory cd8-positive, alpha-beta t cell Cd4-positive, alpha-beta cytotoxic t cell Central memory cd4-positive, alpha-beta t cell Activated cd4-positive, alpha-beta t cell, human Neutrophil Memory b cell Immature neutrophil Regulatory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Hematopoietic stem cell Non-classical monocyte Plasmacytoid dendritic cell, human Lymphocyte Cd16-negative, cd56-bright natural killer cell, human Natural killer cell Platelet Erythrocyte Activated cd8-positive, alpha-beta t cell, human Conventional dendritic cell Classical monocyte Naive b cell Transitional stage b cell

Blood

80 year-old and over stage 53-year-old stage 48-year-old stage 70-year-old stage 38-year-old stage 59-year-old stage 75-year-old stage 68-year-old stage 60-year-old stage 84-year-old stage 47-year-old stage

Covid-19 Normal

Female Male

10x 3' v3

Cell

Homo sapiens

Fibroblast Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Vascular associated smooth muscle cell Pericyte Leukocyte Ependymal cell Central nervous system macrophage Choroid plexus epithelial cell Neuron Endothelial cell

Midbrain nucleus

42-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Myeloid cell Malignant cell Dendritic cell Natural killer cell Macrophage Mesothelial cell Lymphocyte of b lineage T cell

Pleural effusion

Adult stage

Luminal b breast carcinoma Luminal a breast carcinoma Triple-negative breast carcinoma

10x 3' v3

Cell

Homo sapiens

Basophil mast progenitor cell Class switched memory b cell Hematopoietic multipotent progenitor cell Cd16-positive, cd56-dim natural killer cell, human Effector memory cd8-positive, alpha-beta t cell Unswitched memory b cell Early promyelocyte Fraction a pre-pro b cell Cd4-positive, alpha-beta cytotoxic t cell Lymphoid lineage restricted progenitor cell Pro-b cell Common dendritic progenitor Cd4-positive, alpha-beta memory t cell Memory b cell Small pre-b-ii cell Plasma cell Immature b cell Gamma-delta t cell Mesenchymal cell Erythroid progenitor cell Naive thymus-derived cd4-positive, alpha-beta t cell Pre-natural killer cell Naive thymus-derived cd8-positive, alpha-beta t cell Non-classical monocyte Precursor b cell Plasmacytoid dendritic cell Erythroid lineage cell Progenitor cell Megakaryocyte-erythroid progenitor cell Cd16-negative, cd56-bright natural killer cell, human Central memory cd8-positive, alpha-beta t cell Natural killer cell Late promyelocyte Myelocyte Conventional dendritic cell Cd8-positive, alpha-beta memory t cell Classical monocyte Naive b cell Megakaryocyte progenitor cell

Bone marrow

26-year-old stage 59-year-old stage 69-year-old stage 25-year-old stage 65-year-old stage 34-year-old stage

Normal

Female Male

Bd rhapsody targeted mrna

Cell

Homo sapiens

Mast cell Glial cell Smooth muscle cell Myeloid dendritic cell Hematopoietic precursor cell Neutrophil Epithelial cell Stromal cell Oocyte Plasma cell B cell Ovarian surface epithelial cell Stromal cell of ovary Plasmacytoid dendritic cell Glandular secretory epithelial cell Leukocyte Cd8-positive, alpha-beta t cell Blood vessel smooth muscle cell Macrophage Theca cell Monocyte Mature nk t cell Classical monocyte Cd4-positive, alpha-beta t cell T cell Endothelial cell

Right ovary Ovary Left ovary

26-year-old stage 55-year-old stage 56-year-old stage

Normal

Female

10x 3' v3 Smart-seq3 Smart-seq2

Cell

Macaca mulatta

Medium spiny neuron

Primary motor cortex Perirhinal cortex Inferior temporal gyrus Midbrain Cerebrocerebellum Primary visual cortex Nucleus accumbens Dorsolateral prefrontal cortex Primary somatosensory cortex Medial dorsal nucleus of thalamus Lateral geniculate body Ventral lateral nucleus of thalamus Amygdala Brodmann (1909) area 19 Inferior parietal cortex Primary auditory cortex Cerebellar vermis Pons Entorhinal cortex Hippocampal formation Anterior cingulate cortex Prefrontal cortex Superior parietal cortex Superior temporal sulcus Corpus callosum Medulla oblongata Head of caudate nucleus

Prime adult stage Juvenile stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Cultured cell

Calu-3

Covid-19 Severe acute respiratory syndrome Normal

Drop-seq

Cell

Homo sapiens

Fibroblast Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Vascular associated smooth muscle cell Pericyte Leukocyte Central nervous system macrophage Choroid plexus epithelial cell Neuron Endothelial cell

Lateral geniculate body

42-year-old stage 50-year-old stage 29-year-old stage

Normal

Male

10x 3' v3

Nucleus