Homo sapiens

Neutrophil Club cell Dendritic cell, human Stromal cell Natural killer cell Erythrocyte Pulmonary capillary endothelial cell Myeloid dendritic cell, human Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Basal cell Classical monocyte Smooth muscle cell Lung multiciliated epithelial cell Lung macrophage Regulatory t cell Pulmonary alveolar type 1 cell Lung endothelial cell Fibroblast of lung Plasma cell Cd4-positive, alpha-beta t cell Mesothelial cell B cell Monocyte Pulmonary alveolar type 2 cell Lung pericyte Non-classical monocyte

Upper lobe of left lung

62-year-old stage

Covid-19

Male

10x 3' v3

Cell

Mus musculus

Seminal vesicle glandular cell Luminal cell of prostate epithelium Prostate gland microvascular endothelial cell Leukocyte Fibroblast of connective tissue of prostate Urethra urothelial cell Smooth muscle cell of prostate Basal cell of prostate epithelium

Prostate gland Urethra

2-month-old stage

Normal

Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Pvalb chandelier gabaergic interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Choroid plexus epithelial cell Bergmann glial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Purkinje cell Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast

Pontine tegmentum

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Mus musculus

T cell Stromal cell Natural killer cell Endothelial cell of lymphatic vessel Endothelial cell Epithelial cell Adipocyte Macrophage Mural cell Glial cell Mesenchymal stem cell of adipose tissue Mesothelial cell B cell Monocyte Dendritic cell

Normal

10x 3' v3

Homo sapiens

Intestinal crypt stem cell of colon Secretory cell Tuft cell of colon Best4+ colonocyte Malignant cell Colon goblet cell Early colonocyte Colonocyte Enteroendocrine cell of colon

Lung Caecum Peritoneum Liver Hepatic flexure of colon Rectum Transverse colon Chest wall Descending colon Sigmoid colon

37-year-old stage 75-year-old stage 65-year-old stage 53-year-old stage 52-year-old stage 68-year-old stage 48-year-old stage 39-year-old stage 44-year-old stage 55-year-old stage 50-year-old stage 74-year-old stage 49-year-old stage 35-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 73-year-old stage 40-year-old stage

Colorectal cancer Normal

Female Male

10x 3' v3

Cell

Homo sapiens

T cell Podocyte Renal principal cell Parietal epithelial cell Endothelial cell Kidney loop of henle thin descending limb epithelial cell Renal intercalated cell Kidney distal convoluted tubule epithelial cell Kidney connecting tubule epithelial cell Interstitial cell Myeloid cell B cell Kidney loop of henle ascending limb epithelial cell Kidney loop of henle thin ascending limb epithelial cell Kidney proximal convoluted tubule epithelial cell

Kidney

66-year-old stage 69-year-old stage 68-year-old stage 84-year-old stage 82-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 60-year-old stage 63-year-old stage 79-year-old stage 83-year-old stage

Obstructive nephropathy Normal

Female Male

10x multiome

Nucleus

Macaca mulatta

Microglial cell

Dorsolateral prefrontal cortex Brodmann (1909) area 19 Medial dorsal nucleus of thalamus Primary visual cortex Ventral lateral nucleus of thalamus Inferior temporal gyrus Medulla oblongata Prefrontal cortex Midbrain Entorhinal cortex Nucleus accumbens Cerebrocerebellum Primary somatosensory cortex Primary auditory cortex Primary motor cortex Inferior parietal cortex Head of caudate nucleus Corpus callosum Hippocampal formation Perirhinal cortex Pons Cerebellar vermis Anterior cingulate cortex Superior temporal sulcus Superior parietal cortex Lateral geniculate body Amygdala

Juvenile stage Prime adult stage

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Fast muscle cell T cell Neutrophil Granulocyte Natural killer cell Endothelial cell of lymphatic vessel Erythrocyte Slow muscle cell Endothelial cell Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Tendon cell Endothelial cell of artery Capillary endothelial cell Smooth muscle cell Intermediate monocyte Epithelial cell Myeloid dendritic cell Endothelial cell of vascular tree Macrophage Plasma cell Cd4-positive, alpha-beta t cell Mesenchymal cell Mesothelial cell B cell Pericyte Skeletal muscle satellite stem cell Mesenchymal stem cell Monocyte Basophil Non-classical monocyte

Muscle of pelvic diaphragm Muscle of abdomen

61-year-old stage 38-year-old stage 56-year-old stage 59-year-old stage 60-year-old stage

Normal

Female Male

Smart-seq2 10x 3' v3

Cell

Homo sapiens

T cell of anorectum Myeloid cell Stromal cell of lamina propria of colon Plasma cell Colon epithelial cell

Mucosa of ascending colon Mucosa of transverse colon Mucosa of descending colon Mucosa of sigmoid colon Mucosa of rectum

66-year-old stage 21-year-old stage 65-year-old stage 43-year-old stage 61-year-old stage 68-year-old stage 48-year-old stage 56-year-old stage 51-year-old stage 49-year-old stage 23-year-old stage 33-year-old stage 45-year-old stage 46-year-old stage 22-year-old stage 63-year-old stage

Ulcerative colitis Normal Crohn disease

Female Male

10x 3' v3 10x 3' v2

Cell

Mus musculus

Skin fibroblast

Skin of back Skin of body

5-week-old stage 9-week-old stage 12-month-old stage 21-day-old stage Prime adult stage 7-week-old stage 18-month-old stage 22-day-old stage 2-month-old stage

Normal Injury

Female Male

10x 3' v1 10x 3' v3 10x 3' v2

Cell

Homo sapiens

T cell Club cell Blood vessel endothelial cell Ciliated cell Natural killer cell Endothelial cell Mast cell Pulmonary neuroendocrine cell Basal cell Endothelial cell of artery Smooth muscle cell Epithelial cell Goblet cell Macrophage Pulmonary alveolar type 1 cell Alveolar macrophage Vein endothelial cell B cell Pericyte Monocyte Vascular associated smooth muscle cell Myofibroblast cell Fibroblast Dendritic cell Pulmonary alveolar type 2 cell Enucleate erythrocyte Chondrocyte

Lung

31st week post-fertilization stage 3-year-old stage 31-year-old stage

Normal

Female Male

10x 3' v3

Nucleus