Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Dentate gyrus granule cell Cerebellar granule cell Hippocampal ca1-3 neuron Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron Medial ganglionic eminence derived interneuron Ependymal cell Microglial cell Thalamic excitatory neuron Choroid plexus epithelial cell Bergmann glial cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Sst chodl gabaergic interneuron Astrocyte Fibroblast Medium spiny neuron Hippocampal ca4 neuron

Pulvinar nucleus

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Effector cd8-positive, alpha-beta t cell Gamma-delta t cell Exhausted t cell Cd4-positive helper t cell Cd8-positive, alpha-beta memory t cell Regulatory t cell

Pleural effusion Lung Axilla Liver Bone spine Brain Adrenal gland Lymph node

69-year-old stage 75-year-old stage 65-year-old stage 71-year-old stage 85-year-old stage 68-year-old stage 44-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 80-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 74-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 62-year-old stage 70-year-old stage 78-year-old stage 47-year-old stage 76-year-old stage 79-year-old stage 73-year-old stage

Lung adenocarcinoma Normal Small cell lung carcinoma

Female Male

10x 3' transcription profiling 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Cardiac endothelial cell Lymphoid lineage restricted progenitor cell Immature innate lymphoid cell Neuronal receptor cell Pericyte Cardiac muscle myoblast Smooth muscle myoblast Fibroblast of cardiac tissue

Heart left ventricle

66-year-old stage 43-year-old stage 61-year-old stage 52-year-old stage 44-year-old stage 38-year-old stage 55-year-old stage 51-year-old stage 57-year-old stage 74-year-old stage 58-year-old stage 59-year-old stage 64-year-old stage 60-year-old stage 63-year-old stage 47-year-old stage 40-year-old stage

Normal Myocardial infarction

Female Male

10x scatac-seq

Nucleus

Mus musculus

Neural stem cell Glutamatergic neuron Direct pathway medium spiny neuron Endothelial cell Oligodendrocyte Contractile cell Vascular leptomeningeal cell Cholinergic neuron Neural cell Ependymal cell Microglial cell Neuroblast (sensu vertebrata) Neuron associated cell Interneuron Indirect pathway medium spiny neuron Striosomal d1 medium spiny neuron Astrocyte

Postnatal subventricular zone

5-week-old stage

Normal

Mixed sex

10x genomics v2

Homo sapiens

Cd8-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Effector t cell Cd4-positive, alpha-beta t cell Cd4-positive, alpha-beta memory t cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucosal invariant t cell

Stomach Liver Blood Lymph node

Late adult stage

Gastric cancer

Female Male

10x 5' v2

Cell

Homo sapiens

Glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Inhibitory interneuron Medial ganglionic eminence derived interneuron Microglial cell Radial glial cell Pericyte Caudal ganglionic eminence derived interneuron Vascular associated smooth muscle cell Astrocyte Neural progenitor cell

Dorsolateral prefrontal cortex Cortical plate

19th week post-fertilization stage 23rd week post-fertilization stage 39-year-old stage 14-year-old stage 18th week post-fertilization stage Infant stage 20-year-old stage 24th week post-fertilization stage 6-year-old stage 4-year-old stage

Normal

Female Male

10x multiome

Nucleus

Homo sapiens

Central nervous system macrophage Glutamatergic neuron Oligodendrocyte precursor cell Oligodendrocyte Committed oligodendrocyte precursor Endothelial cell of artery Capillary endothelial cell Cerebellar granule cell Leukocyte Microglial cell Mural cell Neuron Vascular associated smooth muscle cell Astrocyte Gabaergic neuron

Cervical spinal cord white matter Brodmann (1909) area 4 White matter of cerebellum

37-year-old stage 34-year-old stage 42-year-old stage 71-year-old stage 61-year-old stage 39-year-old stage 44-year-old stage 72-year-old stage 74-year-old stage 45-year-old stage 63-year-old stage 73-year-old stage 40-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Lamp5 lhx6 neuron Pvalb chandelier gabaergic interneuron

Subthalamic nucleus Medial geniculate body Brodmann (1909) area 25 Lateral amygdaloid nucleus Anterior nuclear group Corticomedial nuclear complex Temporal fusiform gyrus Brodmann (1909) area 19 Centromedian nucleus of thalamus Intralaminar nuclear group Medial dorsal nucleus of thalamus Primary visual cortex Claustrum of brain Inferior temporal gyrus Rostral ca3 Nucleus of medulla oblongata Red nucleus Subicular complex Pontine tegmentum Pontine nuclear group Globus pallidus Piriform cortex Hippocampal field Lateral nuclear group of thalamus Brodmann (1909) area 13 Middle temporal gyrus Central amygdaloid nucleus Ventral anterior nucleus of thalamus Septal nuclear complex Median tuberal portion Extrastriate cortex Epithalamus Dorsal tegmental nucleus Brodmann (1909) area 38 Lateral entorhinal cortex Supraoptic nucleus Brodmann (1909) area 32 Medial entorhinal cortex Midbrain tectum Brodmann (1909) area 40 Inferior frontal gyrus Substantia nigra Agranular insular cortex Brodmann (1909) area 43 Nucleus accumbens Gray matter of midbrain Substantia innominata Anterior cortical amygdaloid nucleus Primary somatosensory cortex Brodmann (1909) area 14 Anterior olfactory nucleus Accessory basal amygdaloid nucleus Pulvinar nucleus Primary auditory cortex Hypothalamus Brodmann (1909) area 23 Primary motor cortex Brodmann (1909) area 24 Brodmann (1909) area 46 Medial zone of hypothalamus Posterior parahippocampal gyrus Basolateral amygdaloid nuclear complex Perirhinal cortex Granular insular cortex Retrosplenial region Cuneus cortex Dentate gyrus of hippocampal formation Lateral posterior nucleus of thalamus Mammillary body Superior temporal gyrus Body of caudate nucleus Uncal ca1 Bed nucleus of stria terminalis Superior parietal cortex Lateral geniculate body Putamen Pretectal region Nucleus of dorsal thalamus Preoptic area

42-year-old stage 29-year-old stage 50-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Ciliated cell Secretory cell Endothelial cell Mast cell Basal cell of olfactory epithelium Goblet cell Macrophage Myeloid cell Plasma cell Glandular secretory epithelial cell Eosinophil Fibroblast

Normal Chronic rhinitis

Seq-well

Homo sapiens

Igg plasmablast Effector cd8-positive, alpha-beta t cell Neutrophil Granulocyte Natural killer cell Erythrocyte Gamma-delta t cell Platelet Plasmacytoid dendritic cell Cd8-positive, alpha-beta memory t cell Iga plasmablast Cd4-positive, alpha-beta t cell Cd14-positive monocyte Cd4-positive, alpha-beta memory t cell B cell Naive t cell Monocyte Conventional dendritic cell Class switched memory b cell

Blood

37-year-old stage Sixth decade stage 48-year-old stage Fifth decade stage Third decade stage 80 year-old and over stage 49-year-old stage Seventh decade stage 36-year-old stage Fourth decade stage

Covid-19 Normal

Female Male

Seq-well

Cell

Drosophila melanogaster

Neuron Fat cell Tracheolar cell Somatic precursor cell Hemocyte Spermatid Spermatocyte cyst cell Spermatogonium Epithelial cell Germline cell Muscle cell Adult tracheocyte Adult neuron Early elongation stage spermatid Head cyst cell Mid-late elongation-stage spermatid Spermatocyte Pigment cell Early-mid elongation-stage spermatid

Testis

Day 1 of adulthood

Normal

Male

10x 3' v3