Homo sapiens

Mast cell Fibroblast Pericyte T cell Myeloid cell Epithelial cell Endothelial cell B cell Cell

Colorectal carcinoma Normal Lung cancer Prostate cancer Ovarian cancer Clear cell renal carcinoma Pancreatic ductal adenocarcinoma Breast carcinoma Liver cancer Urinary bladder cancer

10x technology Visium spatial gene expression 10x 3' v2 10x 3' v3 10x 5' transcription profiling Smart-seq2

Callithrix jacchus

Oligodendrocyte Fibroblast Mural cell Ependymal cell Oligodendrocyte precursor cell Microglial cell Brain microvascular endothelial cell Neuron Choroid plexus epithelial cell Astrocyte

Normal

10x 3' transcription profiling

Homo sapiens

Mast cell Cardiac neuron Mural cell Myeloid cell Adipocyte Lymphocyte Fibroblast of cardiac tissue Cardiac muscle cell Endothelial cell

Heart left ventricle Apex of heart Heart right ventricle Interventricular septum

Fifth decade stage Pediatric stage Eighth decade stage Fourth decade stage Seventh decade stage Postnatal stage Sixth decade stage Third decade stage

Normal Non-compaction cardiomyopathy Dilated cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy

Female Male

10x 3' v2 10x 3' v3

Nucleus

Homo sapiens

Memory regulatory t cell Memory ccr4-positive regulatory t cell T cell Central memory cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta regulatory t cell Cd4-positive, alpha-beta memory t cell Effector memory cd4-positive, alpha-beta t cell Naive regulatory t cell

Blood

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 84-year-old stage 42-year-old stage 49-year-old stage 86-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 83-year-old stage 89-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 45-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 88-year-old stage 87-year-old stage 60-year-old stage 62-year-old stage 79-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage

Normal Cytomegalovirus infection

Female Male

10x gene expression flex

Cell

Homo sapiens

Natural killer cell Endothelial cell of arteriole Classical monocyte Mast cell Fibroblast Monocyte Pericyte Myelinating schwann cell Macrophage Dendritic cell T cell Non-myelinating schwann cell Retinal pigment epithelial cell Endothelial cell of venule Blood vessel smooth muscle cell Platelet Plasma cell Fenestrated endothelial cell Endothelial cell of artery B cell Melanocyte

Chorioretinal region

24th week post-fertilization stage 80 year-old and over stage 64-year-old stage 15th week post-fertilization stage 50-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 63-year-old stage 11th week post-fertilization stage 58-year-old stage 21st week post-fertilization stage 14th week post-fertilization stage 34-year-old stage 86-year-old stage 25-year-old stage 13th week post-fertilization stage 11-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 77-year-old stage 47-year-old stage 32-year-old stage 12th week post-fertilization stage 81-year-old stage 69-year-old stage Newborn stage (0-28 days) 17th week post-fertilization stage 60-year-old stage 62-year-old stage 16-year-old stage 10-year-old stage 30-year-old stage 18th week post-fertilization stage 72-year-old stage 27-year-old stage 17-year-old stage 71-year-old stage

Normal

Female Male

10x 3' v3 10x 5' v2

Nucleus

Homo sapiens

Non-classical monocyte Natural killer cell Classical monocyte Cd8-positive, alpha-beta t cell Mast cell Blood cell Megakaryocyte-erythroid progenitor cell Gamma-delta t cell Dendritic cell Plasmablast Enucleated reticulocyte Double negative t regulatory cell Double-positive, alpha-beta thymocyte Mucosal invariant t cell Cd4-positive, alpha-beta t cell B cell Hematopoietic stem cell

Blood

Fifth decade stage 90 year-old and over stage Ninth decade stage Eighth decade stage Fourth decade stage Seventh decade stage Young adult stage Sixth decade stage

Normal Covid-19 Influenza

Female Male

10x 5' v1

Cell

Homo sapiens

Schwann cell Keratocyte Endothelial cell of lymphatic vessel Mast cell Leukocyte Fibroblast Corneal endothelial cell Progenitor cell Monocyte Pericyte Myelinating schwann cell Macrophage Epithelial cell Lymphocyte Blood vessel endothelial cell Conjunctival epithelial cell Endothelial cell Smooth muscle cell B cell Melanocyte

Corneal epithelium Cornea Corneal endothelium Substantia propria of cornea Corneo-scleral junction Ocular surface region Sclera Tunica fibrosa of eyeball

64-year-old stage 15th week post-fertilization stage 65-year-old stage 43-year-old stage 41-year-old stage 90 year-old and over stage 11th week post-fertilization stage 21st week post-fertilization stage 22-year-old stage 75-year-old stage 84-year-old stage 22nd week post-fertilization stage 14th week post-fertilization stage 34-year-old stage 86-year-old stage 23rd week post-fertilization stage 25-year-old stage 13th week post-fertilization stage 61-year-old stage 11-year-old stage 2-year-old stage 74-year-old stage Eighth decade stage 19th week post-fertilization stage 1-year-old stage 83-year-old stage 53-year-old stage 55-year-old stage 77-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage Newborn stage (0-28 days) 17th week post-fertilization stage Postnatal stage 13-year-old stage 87-year-old stage 62-year-old stage 16-year-old stage 10-year-old stage 39-year-old stage 18th week post-fertilization stage 72-year-old stage 27-year-old stage 20th week post-fertilization stage 48-year-old stage 51-year-old stage 33-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x multiome

Cell Nucleus

Mus musculus

Mature nk t cell Neutrophil Naive b cell Transitional stage b cell Leukocyte Common myeloid progenitor Basophil Group 3 innate lymphoid cell T-helper 17 cell Group 2 innate lymphoid cell Lymphoid tissue–inducer cell Macrophage T cell Marginal zone b cell of lymph node Cytotoxic t cell Plasmablast Naive t cell Eosinophil Conventional dendritic cell Cycling t cell Germinal center b cell Natural t-regulatory cell Plasma cell Cd103-positive dendritic cell Centrocyte Mucosal invariant t cell Plasmacytoid dendritic cell Follicular b cell Bm3 b cell

Normal

10x 3' v3

Homo sapiens

Schwann cell Interstitial cell of cajal Pulmonary alveolar type 1 cell Pancreatic a cell Type b pancreatic cell Hepatoblast Pericyte Hematopoietic cell Club cell Mesodermal cell Paneth cell Ciliated cell Enteroendocrine cell Epithelial cell of stomach Pancreatic d cell Colon epithelial cell Mesothelial cell Pancreatic ductal cell Epithelial cell Hepatic stellate cell Acinar cell Kupffer cell Pulmonary alveolar type 2 cell Enterocyte Best4+ enterocyte Stromal cell Stem cell Goblet cell Pancreatic epsilon cell M cell of gut Neuron Endothelial cell Neuroendocrine cell Smooth muscle cell Luminal cell of prostate epithelium Epithelial cell of pancreas Intestinal tuft cell Basal cell Lung secretory cell Thymocyte

Liver Colon Ileum Duodenum Pancreas Bronchus Corpus Intestine Common bile duct Stomach Thyroid gland Salivary gland epithelium Gallbladder Pyloric antrum Prostate gland Lung Intrahepatic bile duct Nasopharynx Lung epithelium Biliary system Alveolar sac

Normal

Cel-seq2 10x 3' v2 Seq-well s3 10x 3' v3 10x multiome 10x 5' v1 Smart-seq Sort-seq

Cell Nucleus

Homo sapiens

Endothelial cell of lymphatic vessel Basal-myoepithelial cell of mammary gland Leukocyte Mural cell Luminal hormone-sensing cell of mammary gland Fibroblast of mammary gland Luminal adaptive secretory precursor cell of mammary gland Mammary gland epithelial cell Blood vessel endothelial cell Perivascular cell Luminal epithelial cell of mammary gland

Breast

52-year-old stage 65-year-old stage 41-year-old stage 35-year-old stage 63-year-old stage 37-year-old stage 29-year-old stage 58-year-old stage 24-year-old stage 34-year-old stage 31-year-old stage 59-year-old stage 25-year-old stage 57-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 20-year-old stage 36-year-old stage 45-year-old stage 40-year-old stage 62-year-old stage 19-year-old stage 39-year-old stage 28-year-old stage 38-year-old stage 23-year-old stage 30-year-old stage 27-year-old stage 48-year-old stage 33-year-old stage

Normal

Female

10x 3' v3

Cell

Homo sapiens

Naive thymus-derived cd4-positive, alpha-beta t cell

Blood

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 84-year-old stage 42-year-old stage 49-year-old stage 86-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 83-year-old stage 89-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 45-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 88-year-old stage 87-year-old stage 60-year-old stage 62-year-old stage 79-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage

Normal Cytomegalovirus infection

Female Male

10x gene expression flex

Cell

Mus musculus Homo sapiens

Oligodendrocyte Interneuron Fibroblast Cerebellar golgi cell Endothelial stalk cell Inhibitory interneuron Purkinje cell Macrophage Ependymal cell Cerebellar neuron Oligodendrocyte precursor cell Astrocyte of the cerebellum Cerebellar granule cell Microglial cell Endothelial cell Obsolete excitatory neuron Bergmann glial cell

Normal

10x 3' v3