Homo sapiens

Iga plasma cell Innate lymphoid cell Plasmablast Schwann cell Keratinocyte Mast cell Igg plasma cell Vein endothelial cell Hair follicular keratinocyte Smooth muscle cell Melanocyte Neutrophil Dendritic cell Gamma-delta t cell Regulatory t cell Sweat secreting cell Capillary endothelial cell Pericyte Sebaceous gland cell Skin fibroblast Cd8-positive, alpha-beta t cell Endothelial cell of lymphatic vessel Natural killer cell Macrophage T cell Naive b cell Endothelial cell of artery

Atopic eczema Normal

10x 3' v3

Homo sapiens

Astrocyte Oligodendrocyte precursor cell Oligodendrocyte Neural cell Microglial cell

Primary motor cortex Caudal ganglionic eminence Cerebral cortex Ganglionic eminence Temporal cortex Insular cortex Lateral ganglionic eminence Cingulate cortex Frontal cortex Medial ganglionic eminence

54-year-old stage 39-year-old stage Ninth lmp month stage 53-year-old stage 19-year-old stage 21-year-old stage Infant stage 13-year-old stage Newborn stage (0-28 days) 1-month-old stage 17-year-old stage 1-year-old stage 4-year-old stage 6-year-old stage 40-year-old stage 12-year-old stage 45-year-old stage 3-year-old stage 10-year-old stage 2-month-old stage 3-month-old stage 14-year-old stage 2-year-old stage 22-year-old stage 15-year-old stage Fifth lmp month stage Seventh lmp month stage Fourth lmp month stage 5-month-old stage 28-year-old stage 4-month-old stage 5-year-old stage 8-year-old stage 25-year-old stage 20-year-old stage Sixth lmp month stage 44-year-old stage 34-year-old stage 16-year-old stage Eighth lmp month stage

Normal

Female Male

10x multiome 10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Fibroblast Regular atrial cardiac myocyte Myeloid cell Mast cell Regular ventricular cardiac myocyte Mural cell Lymphocyte Neural cell Adipocyte Endothelial cell of lymphatic vessel Mesothelial cell Endothelial cell

Heart left ventricle Apex of heart Left cardiac atrium Interventricular septum Right cardiac atrium Sinoatrial node Heart right ventricle Atrioventricular node

Third decade stage Sixth decade stage Eighth decade stage Fifth decade stage Seventh decade stage

Normal

Female Male

10x multiome 10x 3' v3 10x 3' v2

Cell Nucleus

Homo sapiens

L6b glutamatergic neuron of the primary motor cortex Astrocyte Lamp5 gabaergic interneuron L6 intratelencephalic projecting glutamatergic neuron Gabaergic neuron Smooth muscle cell L2/3 intratelencephalic projecting glutamatergic neuron Vip gabaergic interneuron Oligodendrocyte precursor cell L2/3-6 intratelencephalic projecting glutamatergic neuron Plasma cell Oligodendrocyte B cell L6 corticothalamic-projecting glutamatergic cortical neuron Pericyte L5/6 near-projecting glutamatergic neuron Pvalb gabaergic interneuron Natural killer cell Sst gabaergic interneuron Perivascular macrophage L5 extratelencephalic projecting glutamatergic cortical neuron Vascular leptomeningeal cell Microglial cell T cell Endothelial cell

Dorsolateral prefrontal cortex

54-year-old stage 78-year-old stage 80 year-old and over stage 73-year-old stage 74-year-old stage 72-year-old stage 83-year-old stage 85-year-old stage 81-year-old stage 82-year-old stage 86-year-old stage 70-year-old stage 75-year-old stage 79-year-old stage 89-year-old stage 64-year-old stage 68-year-old stage 66-year-old stage 77-year-old stage 69-year-old stage 76-year-old stage 88-year-old stage 87-year-old stage 80-year-old stage 84-year-old stage 67-year-old stage 65-year-old stage 71-year-old stage

Lewy body dementia Diabetes mellitus Dementia Amyotrophic lateral sclerosis Parkinson disease Head injury Vascular dementia Tauopathy Normal Alzheimer disease Frontotemporal dementia

Female Male

10x 3' v3

Nucleus

Homo sapiens

Offx cell Invaginating midget bipolar cell Retinal bipolar neuron Diffuse bipolar 3b cell Diffuse bipolar 4 cell Diffuse bipolar 3a cell Diffuse bipolar 6 cell Giant bipolar cell On-blue cone bipolar cell Rod bipolar cell Flat midget bipolar cell Diffuse bipolar 1 cell Diffuse bipolar 2 cell

Peripheral region of retina Fovea centralis Macula lutea proper Macula lutea

62-year-old stage 27-year-old stage 78-year-old stage 80 year-old and over stage 73-year-old stage 74-year-old stage 72-year-old stage 53-year-old stage 21-year-old stage 83-year-old stage 85-year-old stage 81-year-old stage 82-year-old stage 17-year-old stage 52-year-old stage 86-year-old stage 70-year-old stage 41-year-old stage Eighth decade stage 3-year-old stage 30-year-old stage 10-year-old stage 58-year-old stage 75-year-old stage 90 year-old and over stage 15-year-old stage 18-year-old stage 50-year-old stage 64-year-old stage 68-year-old stage 66-year-old stage 77-year-old stage 11-year-old stage Late adult stage 69-year-old stage 32-year-old stage 76-year-old stage 88-year-old stage 63-year-old stage 60-year-old stage 80-year-old stage Prime adult stage 84-year-old stage 25-year-old stage 46-year-old stage 24-year-old stage 67-year-old stage 43-year-old stage 60-79 year-old stage 65-year-old stage 71-year-old stage 34-year-old stage 16-year-old stage 47-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Innate lymphoid cell Plasmablast Effector memory cd4-positive, alpha-beta t cell Double negative thymocyte Mucosal invariant t cell Effector memory cd8-positive, alpha-beta t cell Cd14-low, cd16-positive monocyte Cd14-positive monocyte Hematopoietic precursor cell Central memory cd4-positive, alpha-beta t cell Cd141-positive myeloid dendritic cell Memory b cell B cell Gamma-delta t cell Regulatory t cell Cd1c-positive myeloid dendritic cell Naive thymus-derived cd4-positive, alpha-beta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Cd16-negative, cd56-bright natural killer cell, human Central memory cd8-positive, alpha-beta t cell Natural killer cell Platelet Cd4-positive, alpha-beta t cell Naive b cell

Blood

20-year-old stage

Normal

Male

Scalebio single cell rna sequencing

Cell

Homo sapiens

Kidney loop of henle thick ascending limb epithelial cell Kidney proximal convoluted tubule epithelial cell Kidney granular cell Podocyte Kidney interstitial fibroblast Leukocyte Kidney distal convoluted tubule epithelial cell Mesangial cell Blood vessel smooth muscle cell Macrophage Kidney collecting duct intercalated cell Macula densa epithelial cell Kidney collecting duct principal cell Endothelial cell

Cortex of kidney Renal medulla

54-year-old stage 62-year-old stage 72-year-old stage 53-year-old stage 50-year-old stage 64-year-old stage 56-year-old stage 65-year-old stage

Normal

Female Male

Slide-seqv2

Homo sapiens

Mature microglial cell Oligodendrocyte precursor cell Oligodendrocyte Vascular associated smooth muscle cell Pericyte Smooth muscle cell of the brain vasculature Ependymal cell Macrophage Hippocampal pyramidal neuron Vascular leptomeningeal cell Hippocampal interneuron T cell Hippocampal astrocyte Endothelial cell Hippocampal granule cell

Hippocampal formation

54-year-old stage 26-year-old stage 42-year-old stage 48-year-old stage 40-year-old stage 50-year-old stage 51-year-old stage 79-year-old stage 29-year-old stage 60-year-old stage 37-year-old stage 24-year-old stage 44-year-old stage

Normal

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

Fibroblast Alveolar type 1 fibroblast cell Innate lymphoid cell Lung pericyte Group 3 innate lymphoid cell, human Common myeloid progenitor Hematopoietic multipotent progenitor cell Cd16-positive, cd56-dim natural killer cell, human Mast cell Large pre-b-ii cell Cd14-low, cd16-positive monocyte Group 2 innate lymphoid cell Granulocyte Early lymphoid progenitor Cd14-positive monocyte Fraction a pre-pro b cell Smooth muscle cell Lung secretory cell Neutrophil Pro-b cell Epithelial cell of distal tubule Early pro-b cell Immature b cell Dendritic cell Regulatory t cell Megakaryocyte Late pro-b cell Precursor b cell Plasmacytoid dendritic cell Erythroid lineage cell Alveolar adventitial fibroblast Cd8-positive, alpha-beta t cell Megakaryocyte-erythroid progenitor cell Cd16-negative, cd56-bright natural killer cell, human Granulocyte monocyte progenitor cell Natural killer cell Macrophage Mature b cell Group 1 innate lymphoid cell Pro-t cell Myelocyte Conventional dendritic cell Ciliated cell Monocyte Cd4-positive, alpha-beta t cell Megakaryocyte progenitor cell Cd22-positive, cd38-low small pre-b cell Endothelial cell

Lung

Carnegie stage 19 21st week post-fertilization stage Carnegie stage 20 14th week post-fertilization stage 10th week post-fertilization stage Carnegie stage 23 16th week post-fertilization stage Carnegie stage 22 Carnegie stage 13 20th week post-fertilization stage 15th week post-fertilization stage 11th week post-fertilization stage 13th week post-fertilization stage 12th week post-fertilization stage 22nd week post-fertilization stage 18th week post-fertilization stage 9th week post-fertilization stage 17th week post-fertilization stage Carnegie stage 16

Normal

Female Male

10x 5' transcription profiling 10x 5' v1 10x 3' v2

Cell

Homo sapiens

Myeloid cell Astrocyte Malignant cell Oligodendrocyte Pericyte Lymphocyte Neuron Endothelial cell

Glioblastoma

10x 5' v3

Homo sapiens

Cd34-positive, cd38-negative hematopoietic stem cell Iga plasma cell Plasmablast Effector memory cd4-positive, alpha-beta t cell Class switched memory b cell Mucosal invariant t cell Cd16-positive, cd56-dim natural killer cell, human Igg plasma cell Effector memory cd8-positive, alpha-beta t cell Unswitched memory b cell Dendritic cell, human Cd14-low, cd16-positive monocyte T-helper 22 cell Myeloid lineage restricted progenitor cell Cd14-positive monocyte Group 2 innate lymphoid cell, human Myeloid dendritic cell Hematopoietic precursor cell Central memory cd4-positive, alpha-beta t cell Malignant cell Immature b cell T-helper 1 cell Dendritic cell B cell Gamma-delta t cell Regulatory t cell T-helper 17 cell Megakaryocyte Naive thymus-derived cd4-positive, alpha-beta t cell T-helper 2 cell Naive thymus-derived cd8-positive, alpha-beta t cell Plasmacytoid dendritic cell Igm plasma cell Cd8-positive, alpha-beta t cell Ilc1, human Effector cd8-positive, alpha-beta t cell Cd16-negative, cd56-bright natural killer cell, human Natural killer cell Erythroid progenitor cell, mammalian Platelet Erythrocyte Monocyte Mature nk t cell Cd4-positive, alpha-beta t cell Naive b cell T follicular helper cell

Blood

54-year-old stage 39-year-old stage 62-year-old stage 73-year-old stage 26-year-old stage Ninth decade stage Third decade stage 21-year-old stage 83-year-old stage 57-year-old stage Sixth decade stage 49-year-old stage Fourth decade stage 52-year-old stage 70-year-old stage 40-year-old stage 38-year-old stage 59-year-old stage Eighth decade stage 30-year-old stage 55-year-old stage 58-year-old stage 50-year-old stage 51-year-old stage 64-year-old stage 68-year-old stage 66-year-old stage 77-year-old stage 69-year-old stage 76-year-old stage Fifth decade stage 31-year-old stage 87-year-old stage 63-year-old stage 60-year-old stage 80-year-old stage 84-year-old stage 25-year-old stage 56-year-old stage 46-year-old stage 92-year-old stage 65-year-old stage 71-year-old stage Seventh decade stage 44-year-old stage 47-year-old stage

Respiratory system disorder Covid-19 Normal

Female Male

10x 3' transcription profiling

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Primary motor cortex Primary visual cortex Dorsolateral prefrontal cortex Primary somatosensory cortex Primary auditory cortex Middle temporal gyrus Anterior cingulate cortex Angular gyrus

Sixth decade stage 42-year-old stage 50-year-old stage 29-year-old stage 60-year-old stage 43-year-old stage

Normal

Female Male

10x 3' v3

Nucleus