Homo sapiens

Natural killer cell Granulocyte monocyte progenitor cell Promonocyte Monocyte Common myeloid progenitor Megakaryocyte-erythroid progenitor cell T cell Erythroid lineage cell Pro-b cell Conventional dendritic cell Plasma cell Plasmacytoid dendritic cell B cell Hematopoietic stem cell

Bone marrow

85-year-old stage 6-year-old stage 80-year-old stage 64-year-old stage 26-year-old stage 50-year-old stage 52-year-old stage 7-year-old stage 65-year-old stage 43-year-old stage 41-year-old stage 2-month-old stage 35-year-old stage 14-year-old stage 63-year-old stage 5-year-old stage 15-year-old stage 29-year-old stage 58-year-old stage 24-year-old stage 73-year-old stage Adult stage 22-year-old stage 75-year-old stage 3-year-old stage 84-year-old stage 31-year-old stage 42-year-old stage 59-year-old stage 54-year-old stage 19-month-old stage 9-year-old stage 12-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 11-year-old stage 2-year-old stage 74-year-old stage 1-year-old stage 21-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 20-year-old stage 36-year-old stage 32-year-old stage 45-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 67-year-old stage 4-year-old stage 8-month-old stage 13-year-old stage 60-year-old stage 62-year-old stage 19-year-old stage 16-year-old stage 10-year-old stage 39-year-old stage 28-year-old stage 38-year-old stage 8-year-old stage 23-year-old stage 30-year-old stage 79-year-old stage 18-month-old stage 72-year-old stage 17-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage 33-year-old stage

Normal Myeloid leukemia

Female Male

10x transcription profiling 10x 3' v2 10x 3' v3 10x 5' v2 10x 3' v1 Smart-seq2 10x 5' v1 Sort-seq Seq-well

Cell

Homo sapiens

Memory regulatory t cell Memory ccr4-positive regulatory t cell Double negative thymocyte Naive thymus-derived cd4-positive, alpha-beta t cell T cell Central memory cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta regulatory t cell Cd4-positive, alpha-beta memory t cell Effector memory cd4-positive, alpha-beta t cell Naive regulatory t cell

Blood

64-year-old stage 26-year-old stage 65-year-old stage 35-year-old stage 63-year-old stage 29-year-old stage 58-year-old stage 34-year-old stage 31-year-old stage 59-year-old stage 25-year-old stage 12-year-old stage 61-year-old stage 57-year-old stage 11-year-old stage 56-year-old stage 55-year-old stage 36-year-old stage 32-year-old stage 60-year-old stage 62-year-old stage 28-year-old stage 30-year-old stage 27-year-old stage 33-year-old stage

Normal Cytomegalovirus infection

Female Male

10x 3' v3

Cell

Homo sapiens

Mature gamma-delta t cell Naive thymus-derived cd8-positive, alpha-beta t cell Double negative thymocyte Cd8-positive, alpha-beta memory t cell Central memory cd8-positive, alpha-beta t cell Mucosal invariant t cell Cd8aa(i) thymocyte Effector memory cd8-positive, alpha-beta t cell

Blood

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 58-year-old stage 73-year-old stage 75-year-old stage 84-year-old stage 42-year-old stage 49-year-old stage 86-year-old stage 59-year-old stage 54-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage 74-year-old stage 83-year-old stage 89-year-old stage 53-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 45-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 40-year-old stage 88-year-old stage 87-year-old stage 60-year-old stage 62-year-old stage 79-year-old stage 72-year-old stage 48-year-old stage 51-year-old stage 71-year-old stage

Normal Cytomegalovirus infection

Female Male

10x gene expression flex

Cell

Homo sapiens

Lymph node lymphatic vessel endothelial cell Pulmonary alveolar type 1 cell Mast cell Fibroblast Myeloid cell Epithelial cell Lymphocyte Pulmonary alveolar type 2 cell Endothelial cell Apoptosis fated cell Smooth muscle cell B cell

Normal Pulmonary fibrosis Chronic obstructive pulmonary disease Pulmonary systemic sclerosis

10x 3' v2 10x 3' v3 10x 3' v1

Homo sapiens

Mature nk t cell Inflammatory macrophage Non-classical monocyte Natural killer cell Activated cd8-positive, alpha-beta t cell Neutrophil Naive b cell Classical monocyte Endothelial cell of lymphatic vessel Regulatory t cell Capillary endothelial cell Mast cell Vascular associated smooth muscle cell Fibroblast Igg plasma cell Pericyte Activated cd4-positive, alpha-beta t cell Macrophage Gamma-delta t cell T cell Unswitched memory b cell Cd8-positive, alpha-beta memory t cell Mammary gland epithelial cell Vein endothelial cell Myeloid cell Class switched memory b cell Cd4-positive helper t cell Lymphocyte Conventional dendritic cell Effector memory cd4-positive, alpha-beta t cell Iga plasma cell Alternatively activated macrophage Plasmacytoid dendritic cell Myeloid dendritic cell Cd4-positive, alpha-beta t cell Luminal epithelial cell of mammary gland Effector memory cd8-positive, alpha-beta t cell Endothelial cell of artery Basal cell

Breast

Adult stage Prime adult stage

Normal

Female

10x 3' v2 10x 3' v3

Cell

Homo sapiens

Natural killer cell Schwann cell Sebaceous gland cell Neutrophil Naive b cell Cd8-positive, alpha-beta t cell Endothelial cell of lymphatic vessel Regulatory t cell Capillary endothelial cell Mast cell Igg plasma cell Pericyte Macrophage Gamma-delta t cell Dendritic cell T cell Plasmablast Vein endothelial cell Hair follicular keratinocyte Sweat secreting cell Iga plasma cell Skin fibroblast Innate lymphoid cell Smooth muscle cell Endothelial cell of artery Keratinocyte Melanocyte

Normal Atopic eczema

10x 3' v3

Homo sapiens

Oligodendrocyte Neural cell Oligodendrocyte precursor cell Microglial cell Astrocyte

Medial ganglionic eminence Caudal ganglionic eminence Cingulate cortex Primary motor cortex Insular cortex Temporal cortex Lateral ganglionic eminence Ganglionic eminence Cerebral cortex Frontal cortex

6-year-old stage 4-month-old stage 2-month-old stage 14-year-old stage Eighth lmp month stage 5-year-old stage 15-year-old stage 22-year-old stage 3-year-old stage 34-year-old stage Seventh lmp month stage 1-month-old stage 54-year-old stage Sixth lmp month stage 25-year-old stage 12-year-old stage Infant stage 2-year-old stage 1-year-old stage 21-year-old stage 53-year-old stage Fifth lmp month stage 44-year-old stage 20-year-old stage 45-year-old stage 5-month-old stage 4-year-old stage 40-year-old stage Newborn stage (0-28 days) 3-month-old stage 13-year-old stage 19-year-old stage 16-year-old stage 10-year-old stage 39-year-old stage Ninth lmp month stage 28-year-old stage Fourth lmp month stage 8-year-old stage 17-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x multiome

Nucleus

Homo sapiens

Endothelial cell of lymphatic vessel Mast cell Fibroblast Mural cell Mesothelial cell Neural cell Myeloid cell Adipocyte Regular ventricular cardiac myocyte Lymphocyte Regular atrial cardiac myocyte Endothelial cell

Heart left ventricle Sinoatrial node Apex of heart Atrioventricular node Heart right ventricle Right cardiac atrium Interventricular septum Left cardiac atrium

Fifth decade stage Eighth decade stage Seventh decade stage Sixth decade stage Third decade stage

Normal

Female Male

10x 3' v2 10x 3' v3 10x multiome

Cell Nucleus

Homo sapiens

Oligodendrocyte Natural killer cell L5/6 near-projecting glutamatergic neuron L6b glutamatergic neuron of the primary motor cortex Pericyte Vascular leptomeningeal cell Sst gabaergic interneuron L2/3 intratelencephalic projecting glutamatergic neuron T cell Lamp5 gabaergic interneuron Pvalb gabaergic interneuron Perivascular macrophage L6 corticothalamic-projecting glutamatergic cortical neuron Oligodendrocyte precursor cell Plasma cell Microglial cell L2/3-6 intratelencephalic projecting glutamatergic neuron L6 intratelencephalic projecting glutamatergic neuron Endothelial cell Gabaergic neuron Smooth muscle cell B cell Vip gabaergic interneuron L5 extratelencephalic projecting glutamatergic cortical neuron Astrocyte

Dorsolateral prefrontal cortex

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 73-year-old stage 75-year-old stage 84-year-old stage 86-year-old stage 54-year-old stage 66-year-old stage 74-year-old stage 83-year-old stage 89-year-old stage 77-year-old stage 78-year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 88-year-old stage 87-year-old stage 79-year-old stage 72-year-old stage 71-year-old stage

Normal Amyotrophic lateral sclerosis Vascular dementia Lewy body dementia Alzheimer disease Tauopathy Head injury Diabetes mellitus Parkinson disease Frontotemporal dementia Dementia

Female Male

10x 3' v3

Nucleus

Homo sapiens

Retinal bipolar neuron Diffuse bipolar 3a cell Diffuse bipolar 6 cell Diffuse bipolar 2 cell On-blue cone bipolar cell Rod bipolar cell Diffuse bipolar 4 cell Flat midget bipolar cell Invaginating midget bipolar cell Diffuse bipolar 3b cell Diffuse bipolar 1 cell Giant bipolar cell Offx cell

Macula lutea proper Peripheral region of retina Macula lutea Fovea centralis

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 90 year-old and over stage 15-year-old stage 58-year-old stage 24-year-old stage 73-year-old stage Late adult stage 75-year-old stage 3-year-old stage 84-year-old stage 34-year-old stage 86-year-old stage 25-year-old stage 66-year-old stage 11-year-old stage 74-year-old stage Eighth decade stage 21-year-old stage 83-year-old stage 53-year-old stage 46-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 32-year-old stage 60-79 year-old stage 70-year-old stage 81-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 88-year-old stage 60-year-old stage 62-year-old stage 16-year-old stage 10-year-old stage 18-year-old stage Prime adult stage 30-year-old stage 72-year-old stage 27-year-old stage 17-year-old stage 71-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Retinal bipolar neuron Diffuse bipolar 3a cell Diffuse bipolar 6 cell Diffuse bipolar 2 cell On-blue cone bipolar cell Rod bipolar cell Diffuse bipolar 4 cell Flat midget bipolar cell Invaginating midget bipolar cell Diffuse bipolar 3b cell Diffuse bipolar 1 cell Giant bipolar cell Offx cell

Normal

10x 3' v3

Homo sapiens

Natural killer cell Naive b cell Regulatory t cell Cd1c-positive myeloid dendritic cell Cd14-positive monocyte Naive thymus-derived cd8-positive, alpha-beta t cell Memory b cell Double negative thymocyte Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Cd14-low, cd16-positive monocyte Hematopoietic precursor cell Central memory cd4-positive, alpha-beta t cell Plasmablast Cd16-negative, cd56-bright natural killer cell, human Platelet Central memory cd8-positive, alpha-beta t cell Effector memory cd4-positive, alpha-beta t cell Mucosal invariant t cell Plasmacytoid dendritic cell Cd141-positive myeloid dendritic cell Innate lymphoid cell Cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell B cell

Blood

20-year-old stage

Normal

Male

Scalebio single cell rna sequencing

Cell