Homo sapiens

Kidney interstitial fibroblast Leukocyte Mesangial cell Kidney proximal convoluted tubule epithelial cell Kidney collecting duct intercalated cell Kidney collecting duct principal cell Macrophage Kidney loop of henle thick ascending limb epithelial cell Blood vessel smooth muscle cell Kidney distal convoluted tubule epithelial cell Kidney granular cell Endothelial cell Podocyte Macula densa epithelial cell

Renal medulla Cortex of kidney

64-year-old stage 50-year-old stage 65-year-old stage 54-year-old stage 53-year-old stage 56-year-old stage 62-year-old stage 72-year-old stage

Normal

Female Male

Slide-seqv2

Homo sapiens

Oligodendrocyte Hippocampal interneuron Vascular associated smooth muscle cell Pericyte Mature microglial cell Vascular leptomeningeal cell Macrophage T cell Ependymal cell Oligodendrocyte precursor cell Hippocampal astrocyte Hippocampal pyramidal neuron Smooth muscle cell of the brain vasculature Endothelial cell Hippocampal granule cell

Hippocampal formation

26-year-old stage 50-year-old stage 37-year-old stage 29-year-old stage 24-year-old stage 42-year-old stage 54-year-old stage 44-year-old stage 40-year-old stage 60-year-old stage 79-year-old stage 48-year-old stage 51-year-old stage

Normal

Female Male

10x 3' v2 10x 3' v3

Nucleus

Homo sapiens

Megakaryocyte Natural killer cell Neutrophil Alveolar type 1 fibroblast cell Cd8-positive, alpha-beta t cell Late pro-b cell Regulatory t cell Granulocyte monocyte progenitor cell Fraction a pre-pro b cell Mast cell Fibroblast Cd14-positive monocyte Monocyte Common myeloid progenitor Megakaryocyte-erythroid progenitor cell Alveolar adventitial fibroblast Ciliated cell Precursor b cell Group 2 innate lymphoid cell Pro-t cell Macrophage Dendritic cell Hematopoietic multipotent progenitor cell Cd14-low, cd16-positive monocyte Mature b cell Large pre-b-ii cell Cd16-negative, cd56-bright natural killer cell, human Granulocyte Erythroid lineage cell Pro-b cell Conventional dendritic cell Group 3 innate lymphoid cell, human Lung pericyte Cd22-positive, cd38-low small pre-b cell Megakaryocyte progenitor cell Plasmacytoid dendritic cell Endothelial cell Early lymphoid progenitor Innate lymphoid cell Cd4-positive, alpha-beta t cell Cd16-positive, cd56-dim natural killer cell, human Myelocyte Smooth muscle cell Immature b cell Epithelial cell of distal tubule Lung secretory cell Group 1 innate lymphoid cell Early pro-b cell

Lung

15th week post-fertilization stage 11th week post-fertilization stage 21st week post-fertilization stage 22nd week post-fertilization stage 14th week post-fertilization stage 9th week post-fertilization stage 13th week post-fertilization stage Carnegie stage 23 Carnegie stage 22 12th week post-fertilization stage 10th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 19 18th week post-fertilization stage Carnegie stage 16 20th week post-fertilization stage Carnegie stage 20 Carnegie stage 13

Normal

Female Male

10x 3' v2 10x 5' transcription profiling 10x 5' v1

Cell

Homo sapiens

Oligodendrocyte Pericyte Malignant cell Myeloid cell Lymphocyte Neuron Endothelial cell Astrocyte

Glioblastoma

10x 5' v3

Homo sapiens

Mature nk t cell Megakaryocyte Dendritic cell, human Natural killer cell Erythrocyte Naive b cell Cd8-positive, alpha-beta t cell Ilc1, human Regulatory t cell Cd14-positive monocyte Monocyte Igg plasma cell Erythroid progenitor cell, mammalian Myeloid lineage restricted progenitor cell Malignant cell T-helper 22 cell Naive thymus-derived cd8-positive, alpha-beta t cell T-helper 17 cell Cd34-positive, cd38-negative hematopoietic stem cell Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Dendritic cell Group 2 innate lymphoid cell, human Cd14-low, cd16-positive monocyte Unswitched memory b cell Hematopoietic precursor cell Central memory cd4-positive, alpha-beta t cell T-helper 2 cell Plasmablast Class switched memory b cell Cd16-negative, cd56-bright natural killer cell, human Platelet Effector memory cd4-positive, alpha-beta t cell T-helper 1 cell Iga plasma cell Mucosal invariant t cell Plasmacytoid dendritic cell Myeloid dendritic cell Cd4-positive, alpha-beta t cell Cd16-positive, cd56-dim natural killer cell, human T follicular helper cell Effector memory cd8-positive, alpha-beta t cell Effector cd8-positive, alpha-beta t cell Immature b cell B cell Igm plasma cell

Blood

80-year-old stage 64-year-old stage 26-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 68-year-old stage Fifth decade stage 63-year-old stage 58-year-old stage Ninth decade stage 73-year-old stage 84-year-old stage 31-year-old stage 49-year-old stage 59-year-old stage 54-year-old stage 25-year-old stage 92-year-old stage 66-year-old stage 57-year-old stage Eighth decade stage 21-year-old stage 83-year-old stage Fourth decade stage 46-year-old stage 56-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage Seventh decade stage 47-year-old stage 70-year-old stage 76-year-old stage 69-year-old stage 40-year-old stage 87-year-old stage 60-year-old stage 62-year-old stage Sixth decade stage 39-year-old stage 38-year-old stage 30-year-old stage 51-year-old stage 71-year-old stage Third decade stage

Normal Covid-19 Respiratory system disorder

Female Male

10x 3' transcription profiling

Cell

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Angular gyrus Anterior cingulate cortex Primary motor cortex Primary visual cortex Middle temporal gyrus Primary auditory cortex Primary somatosensory cortex Dorsolateral prefrontal cortex

50-year-old stage 43-year-old stage 29-year-old stage 42-year-old stage 60-year-old stage Sixth decade stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Neuron

Embryo

Theiler stage 26 Theiler stage 16 Theiler stage 19 Theiler stage 25 Theiler stage 23 Theiler stage 17 Theiler stage 27 Theiler stage 20 Theiler stage 22 Theiler stage 24 Theiler stage 21 Theiler stage 15 Theiler stage 18

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Cd4-positive, cd25-positive, ccr4-positive, alpha-beta regulatory t cell Natural killer cell Capillary endothelial cell Mast cell Vascular associated smooth muscle cell Fibroblast Igg plasma cell Pericyte Malignant cell Cycling stromal cell Endothelial cell of vascular tree Memory b cell Macrophage Cd8-positive, alpha-beta regulatory t cell Vein endothelial cell Naive t cell Cd4-positive helper t cell Conventional dendritic cell Exhausted t cell Cycling t cell Effector memory cd4-positive, alpha-beta t cell Myofibroblast cell Plasmacytoid dendritic cell Cycling macrophage Myeloid dendritic cell Endothelial cell T follicular helper cell Effector memory cd8-positive, alpha-beta t cell Endothelial cell of artery

Breast

80 year-old and over stage 85-year-old stage 80-year-old stage 64-year-old stage 50-year-old stage 52-year-old stage 65-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage Fifth decade stage 63-year-old stage 37-year-old stage 29-year-old stage 58-year-old stage Ninth decade stage 73-year-old stage Adult stage Late adult stage 84-year-old stage 34-year-old stage 42-year-old stage 49-year-old stage 59-year-old stage 54-year-old stage 25-year-old stage 66-year-old stage 61-year-old stage 57-year-old stage Eighth decade stage 83-year-old stage 46-year-old stage 55-year-old stage Seventh decade stage 47-year-old stage 36-year-old stage 32-year-old stage 60-79 year-old stage 45-year-old stage 70-year-old stage 69-year-old stage 67-year-old stage 88-year-old stage 60-year-old stage 62-year-old stage Sixth decade stage 38-year-old stage Prime adult stage 30-year-old stage 79-year-old stage 71-year-old stage Middle aged stage

Estrogen-receptor positive breast cancer Invasive lobular breast carcinoma Triple-negative breast carcinoma Her2 positive breast carcinoma Invasive ductal breast carcinoma Invasive tubular breast carcinoma Breast apocrine carcinoma Metaplastic breast carcinoma Breast cancer Breast mucinous carcinoma Breast carcinoma

Female Male

10x 3' v2 10x 3' v3 10x 5' transcription profiling 10x 5' v2 10x 5' v1

Cell

Mus musculus

Oligodendrocyte Interneuron Fibroblast Cerebellar golgi cell Endothelial stalk cell Inhibitory interneuron Purkinje cell Macrophage Ependymal cell Oligodendrocyte precursor cell Astrocyte of the cerebellum Cerebellar granule cell Microglial cell Endothelial cell Bergmann glial cell Glutamatergic neuron

Cerebellum

8-week-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Effector memory cd4-positive, alpha-beta t cell, terminally differentiated Group 3 innate lymphoid cell Naive thymus-derived cd8-positive, alpha-beta t cell Naive thymus-derived cd4-positive, alpha-beta t cell Gamma-delta t cell Central memory cd4-positive, alpha-beta t cell Cd8-positive, alpha-beta memory t cell Cd4-positive, alpha-beta memory t cell Central memory cd8-positive, alpha-beta t cell Effector memory cd4-positive, alpha-beta t cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Mucosal invariant t cell Germinal center t cell Effector memory cd8-positive, alpha-beta t cell, terminally differentiated Innate lymphoid cell Cd16-positive, cd56-dim natural killer cell, human Effector memory cd8-positive, alpha-beta t cell

Thoracic lymph node Bone marrow Jejunum lamina propria Epithelial lining fluid Spleen Inguinal lymph node Jejunal epithelium Blood Mesenteric lymph node Lung

64-year-old stage 68-year-old stage Fifth decade stage 73-year-old stage 75-year-old stage 25-year-old stage Eighth decade stage Fourth decade stage 56-year-old stage 20-year-old stage 67-year-old stage Sixth decade stage 23-year-old stage 27-year-old stage 48-year-old stage 33-year-old stage Third decade stage

Normal

Female Male

10x 3' v3 10x 5' v2

Cell

Homo sapiens

Non-classical monocyte Natural killer cell Classical monocyte Cd8-positive, alpha-beta t cell Progenitor cell Gamma-delta t cell Plasmablast Conventional dendritic cell Plasmacytoid dendritic cell Cd4-positive, alpha-beta t cell B cell

Blood

80 year-old and over stage 50-year-old stage 65-year-old stage 68-year-old stage 82-year-old stage 43-year-old stage 41-year-old stage 35-year-old stage 63-year-old stage 37-year-old stage 58-year-old stage 73-year-old stage Adult stage 75-year-old stage 34-year-old stage 31-year-old stage 42-year-old stage 49-year-old stage 86-year-old stage 59-year-old stage 25-year-old stage 66-year-old stage 61-year-old stage 74-year-old stage 83-year-old stage 53-year-old stage 55-year-old stage 44-year-old stage 77-year-old stage 78-year-old stage 47-year-old stage 45-year-old stage 76-year-old stage 69-year-old stage 67-year-old stage 60-year-old stage 62-year-old stage 39-year-old stage 38-year-old stage 79-year-old stage 48-year-old stage 71-year-old stage 33-year-old stage

Normal Covid-19 Respiratory system disorder

Female Male

10x 5' transcription profiling

Cell

Homo sapiens

Oligodendrocyte Professional antigen presenting cell Neutrophil Cell of skeletal muscle Embryonic stem cell Renal intercalated cell Mast cell Kidney loop of henle epithelial cell Fibroblast Inflammatory cell Erythroid progenitor cell Monocyte Epithelial cell of proximal tubule Endocrine cell Sertoli cell Mesenchymal stem cell Macrophage Dendritic cell T cell Peptic cell Mesothelial cell Myeloid cell Ventricular cardiac muscle cell Cord blood hematopoietic stem cell Epithelial cell Erythroid lineage cell Acinar cell Thyroid follicular cell Pulmonary alveolar type 2 cell Enterocyte Plasma cell Stromal cell Goblet cell Alternatively activated macrophage Neuron Endothelial cell Stratified epithelial cell Primordial germ cell Chondrocyte Epithelial cell of exocrine pancreas Smooth muscle cell B cell Basal cell Astrocyte

Liver Spinal cord Kidney Rib Bone marrow Chorionic villus Ureter Ileum Trachea Ascending colon Sigmoid colon Duodenum Pleura Artery Placenta Rectum Pancreas Fallopian tube Intestine Heart Spleen Omentum Vault of skull Stomach Umbilical cord blood Thyroid gland Blood Embryonic stem cell Skin of body Adipose tissue Temporal lobe Gallbladder Bladder organ Brain Uterus Thymus Transverse colon Prostate gland Muscle organ Lung Cerebellum Jejunum Testis Eye Vermiform appendix Uterine cervix Ovary Adrenal gland Esophagus

64-year-old stage 52-year-old stage 43-year-old stage 41-year-old stage 63-year-old stage 11th week post-fertilization stage 58-year-old stage Embryonic stage 14th week post-fertilization stage 34-year-old stage 49-year-old stage 59-year-old stage 26th week post-fertilization stage 25-year-old stage 13th week post-fertilization stage 66-year-old stage 61-year-old stage 57-year-old stage 21-year-old stage 83-year-old stage 46-year-old stage 56-year-old stage 55-year-old stage 47-year-old stage 36-year-old stage 32-year-old stage 12th week post-fertilization stage 45-year-old stage 10th week post-fertilization stage Newborn stage (0-28 days) 60-year-old stage 62-year-old stage 23-year-old stage 30-year-old stage 27-year-old stage 51-year-old stage

Normal

Female Male

Microwell-seq

Cell