Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

6-month-old stage

Normal

Male

Slide-seqv2

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Macula densa epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Diabetic kidney disease

Male

Slide-seqv2

Mus musculus

Kidney cell T cell Natural killer cell Kidney collecting duct epithelial cell Kidney cortex artery cell Leukocyte Kidney capillary endothelial cell Epithelial cell of proximal tubule Plasmatocyte Lymphocyte Tuft cell Macrophage Fenestrated endothelial cell Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Kidney proximal straight tubule epithelial cell Plasma cell Mesangial cell B cell Kidney loop of henle ascending limb epithelial cell Kidney proximal convoluted tubule epithelial cell Fibroblast

Kidney

4-week-old stage 3-month-old stage 20-month-old stage and over 18-month-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Memory b cell Plasmablast

Tonsil

9-year-old stage 3-year-old stage 5-year-old stage 6-year-old stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

Midbrain-derived inhibitory neuron T cell Central nervous system macrophage Natural killer cell Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Committed oligodendrocyte precursor Cerebellar granule cell Medial ganglionic eminence derived interneuron Cerebellar inhibitory gabaergic interneuron Ependymal cell Microglial cell Bergmann glial cell B cell Pericyte Neuron Monocyte Intratelencephalic-projecting glutamatergic cortical neuron Caudal ganglionic eminence derived interneuron Purkinje cell Vascular associated smooth muscle cell Astrocyte Unipolar brush cell Fibroblast

Inferior olivary complex

42-year-old stage 29-year-old stage 50-year-old stage

Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Lamp5 gabaergic interneuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Retinal cone cell Retinal rod cell

Peripheral region of retina Macula lutea proper Fovea centralis

65-year-old stage 84-year-old stage 78-year-old stage 73-year-old stage 83-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Subcutaneous adipocyte Mesenchymal stem cell of adipose tissue

Subcutaneous adipose tissue

34-year-old stage 24-year-old stage 33-year-old stage 41-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Mus musculus

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Kidney

13-week-old stage

Normal

Male

Slide-seqv2

Homo sapiens

Podocyte Endothelial cell Kidney interstitial fibroblast Blood vessel smooth muscle cell Kidney collecting duct intercalated cell Leukocyte Macrophage Kidney distal convoluted tubule epithelial cell Kidney granular cell Kidney collecting duct principal cell Kidney loop of henle thick ascending limb epithelial cell Mesangial cell Kidney proximal convoluted tubule epithelial cell

Renal medulla

65-year-old stage

Normal

Male

Slide-seqv2

Homo sapiens

T cell Neutrophil Luminal cell of prostate epithelium Erythrocyte Endothelial cell Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Smooth muscle cell Macrophage Cd4-positive, alpha-beta t cell B cell Fibroblast Basal cell of prostate epithelium

Prostate gland

56-year-old stage 59-year-old stage 60-year-old stage

Normal

Male

Smart-seq2 10x 3' v3

Cell

Homo sapiens

Intestinal crypt stem cell of colon Secretory cell Tuft cell of colon Best4+ colonocyte Malignant cell Colon goblet cell Early colonocyte Colonocyte Enteroendocrine cell of colon

Caecum Hepatic flexure of colon Rectum Transverse colon Descending colon Sigmoid colon

37-year-old stage 75-year-old stage 65-year-old stage 53-year-old stage 52-year-old stage 68-year-old stage 39-year-old stage 44-year-old stage 55-year-old stage 50-year-old stage 74-year-old stage 49-year-old stage 35-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 41-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 73-year-old stage 40-year-old stage

Colorectal cancer Normal

Female Male

10x 3' v3

Cell