Homo sapiens

Cerebellar neuron Direct pathway medium spiny neuron Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Vip gabaergic interneuron Indirect pathway medium spiny neuron Thalamic excitatory neuron Pvalb gabaergic interneuron Central nervous system neuron Sncg gabaergic interneuron Purkinje cell Sst gabaergic interneuron

Brodmann (1909) area 25 Corticomedial nuclear complex Insula Parietal cortex Brodmann (1909) area 19 Medial dorsal nucleus of thalamus Primary visual cortex Claustrum of brain Inferior temporal gyrus Subiculum Pontine nuclear group Globus pallidus Piriform cortex Hippocampal field Prefrontal cortex Middle temporal gyrus Central amygdaloid nucleus Septal nuclear complex Brodmann (1909) area 38 Lateral entorhinal cortex Medial entorhinal cortex Central nucleus of inferior colliculus Agranular insular cortex Nucleus accumbens Substantia innominata Primary somatosensory cortex Cerebellum Pulvinar nucleus Primary auditory cortex Primary motor cortex Brodmann (1909) area 24 Brodmann (1909) area 46 Posterior parahippocampal gyrus Basolateral amygdaloid nuclear complex Hippocampal formation Granular insular cortex Anterior cingulate cortex Cuneus cortex Dentate gyrus of hippocampal formation Body of caudate nucleus Secondary visual cortex Bed nucleus of stria terminalis Putamen Amygdala

42-year-old stage 29-year-old stage 58-year-old stage

Normal

Male

Snmc-seq2

Nucleus

Homo sapiens

Cerebellar neuron Direct pathway medium spiny neuron Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Vip gabaergic interneuron Indirect pathway medium spiny neuron Thalamic excitatory neuron Pvalb gabaergic interneuron Central nervous system neuron Sncg gabaergic interneuron Purkinje cell Sst gabaergic interneuron

Brodmann (1909) area 25 Corticomedial nuclear complex Insula Parietal cortex Brodmann (1909) area 19 Medial dorsal nucleus of thalamus Primary visual cortex Claustrum of brain Inferior temporal gyrus Subiculum Pontine nuclear group Globus pallidus Piriform cortex Hippocampal field Prefrontal cortex Middle temporal gyrus Central amygdaloid nucleus Septal nuclear complex Brodmann (1909) area 38 Lateral entorhinal cortex Medial entorhinal cortex Central nucleus of inferior colliculus Agranular insular cortex Nucleus accumbens Substantia innominata Primary somatosensory cortex Cerebellum Pulvinar nucleus Primary auditory cortex Primary motor cortex Brodmann (1909) area 24 Brodmann (1909) area 46 Posterior parahippocampal gyrus Basolateral amygdaloid nuclear complex Hippocampal formation Granular insular cortex Anterior cingulate cortex Cuneus cortex Dentate gyrus of hippocampal formation Body of caudate nucleus Secondary visual cortex Bed nucleus of stria terminalis Putamen Amygdala

42-year-old stage 29-year-old stage 58-year-old stage

Normal

Male

Snmc-seq2

Nucleus

Danio rerio

Olfactory epithelial cell Neuromast supporting cell Taste receptor cell Epithelial cell Neuroplacodal cell Odontoblast Endodermal cell Thyroid follicular cell

Pharyngeal pouch Pharynx Lateral line Tooth placode Thyroid follicle Multicellular anatomical structure Pharyngeal arch Genitourinary system Dorsolateral placode Taste bud Olfactory epithelium

Pharyngula:prim-15 Hatching:long-pec Larval:protruding-mouth Pharyngula:prim-25 Segmentation:26+ somites Segmentation:14-19 somites Hatching:pec-fin Segmentation:20-25 somites Pharyngula:high-pec Pharyngula:prim-5

Normal

Sci-rna-seq3

Nucleus

Homo sapiens

T cell Neutrophil Podocyte Parietal epithelial cell Kidney interstitial alternatively activated macrophage Renal interstitial pericyte Endothelial cell Kidney loop of henle thin descending limb epithelial cell Mature nk t cell Kidney interstitial fibroblast Mast cell Kidney collecting duct intercalated cell Epithelial cell of proximal tubule Plasmacytoid dendritic cell, human Neural cell Kidney distal convoluted tubule epithelial cell Kidney collecting duct principal cell Kidney connecting tubule epithelial cell Kidney loop of henle thick ascending limb epithelial cell Plasma cell B cell Kidney loop of henle thin ascending limb epithelial cell Papillary tips cell Conventional dendritic cell Non-classical monocyte Mononuclear phagocyte

Renal medulla Renal papilla Cortex of kidney

66-year-old stage 69-year-old stage Sixth decade stage 54-year-old stage 29-year-old stage 57-year-old stage Third decade stage 14-year-old stage Seventh decade stage 59-year-old stage 45-year-old stage Fourth decade stage 63-year-old stage Eighth decade stage 76-year-old stage

Chronic kidney disease Normal Acute kidney failure

Female Male

10x 3' v3

Nucleus

Homo sapiens

Stromal cell Leukocyte Malignant cell Neuron

Thoracic segment connective tissue Orbital region Pelvis connective tissue Abdomen Limb Genitourinary system Craniocervical region

Pediatric stage Sixth decade stage Nursing stage (0-11 months) Seventh decade stage Postnatal stage

Myofibroma Osteosarcoma Desmoplastic small round cell tumor Rhabdomyosarcoma

10x multiome

Nucleus

Homo sapiens

T cell Natural killer cell Cd8-alpha-alpha-positive, alpha-beta intraepithelial t cell Group 2 innate lymphoid cell Double-positive, alpha-beta thymocyte Early lymphoid progenitor Group 3 innate lymphoid cell Naive thymus-derived cd8-positive, alpha-beta t cell Innate lymphoid cell Regulatory t cell Promonocyte Hematopoietic stem cell Common myeloid progenitor Hematopoietic multipotent progenitor cell Megakaryocyte Granulocyte monocyte progenitor cell Naive thymus-derived cd4-positive, alpha-beta t cell Megakaryocyte-erythroid progenitor cell Fraction a pre-pro b cell Double negative thymocyte

Skin of body Thymus Yolk sac Liver Gut wall Kidney Spleen Bone marrow Mesenteric lymph node

Carnegie stage 19 13th week post-fertilization stage Carnegie stage 13 14th week post-fertilization stage 15th week post-fertilization stage 17th week post-fertilization stage 12th week post-fertilization stage 16th week post-fertilization stage Carnegie stage 20 9th week post-fertilization stage Carnegie stage 23 10th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage

Normal

Female Male

10x 5' v1 10x 3' v2

Cell

Homo sapiens

T cell L2/3 intratelencephalic projecting glutamatergic neuron Oligodendrocyte precursor cell Endothelial cell Oligodendrocyte Vascular leptomeningeal cell Erythroid lineage cell Smooth muscle cell Inhibitory interneuron Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Macrophage L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex Microglial cell Vip gabaergic interneuron Myeloid cell L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron L6 corticothalamic-projecting glutamatergic cortical neuron Pvalb gabaergic interneuron B cell Pericyte Astrocyte L5/6 near-projecting glutamatergic neuron of the primary motor cortex Sst gabaergic interneuron

Dorsolateral prefrontal cortex

50-year-old stage 64-year-old stage 36-year-old stage 19-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Mural cell

Heart right ventricle Apex of heart Heart left ventricle Interventricular septum

Pediatric stage Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Postnatal stage Fourth decade stage Eighth decade stage

Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Normal Non-compaction cardiomyopathy

Female Male

10x 3' v3 10x 3' v2

Nucleus

Homo sapiens

L2/3-6 intratelencephalic projecting glutamatergic neuron

Middle temporal gyrus

69-year-old stage 75-year-old stage 65-year-old stage 89-year-old stage 43-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage Adult stage 77-year-old stage 86-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Stem cell Enteroendocrine cell Goblet cell Tuft cell of colon Enterocyte Intestinal epithelial cell Glandular secretory epithelial cell Colon goblet cell Colonocyte

Colorectum

69-year-old stage 91-year-old stage 42-year-old stage 89-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 48-year-old stage 56-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 90-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 49-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage 47-year-old stage 76-year-old stage 73-year-old stage

Normal Colon adenocarcinoma

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Stromal cell of endometrium Blood vessel endothelial cell Stromal cell Endothelial cell of venule Natural killer cell Endothelial cell of lymphatic vessel Perivascular cell Luminal endometrial multiciliated epithelial cell Hematopoietic precursor cell Mast cell Uterine smooth muscle cell Endothelial cell of artery Capillary endothelial cell Leukocyte Epithelial cell Endothelial cell of uterus Cd8-positive, alpha-beta memory t cell Myoepithelial cell Macrophage Innate lymphoid cell Regulatory t cell Glandular secretory epithelial cell Fibro/adipogenic progenitor cell Cd4-positive, alpha-beta memory t cell Ciliated epithelial cell B cell Circulating fibrocyte Decidual cell Fibroblast Memory t cell

Endometrium Myometrium

37-year-old stage 26-year-old stage 29-year-old stage 28-year-old stage 23-year-old stage 32-year-old stage 31-year-old stage Young adult stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Mature conventional dendritic cell Kupffer cell Classical monocyte Macrophage Apoptosis fated cell Alveolar macrophage Monocyte Conventional dendritic cell Non-classical monocyte

Alcoholic liver cirrhosis Metabolic dysfunction-associated steatohepatitis Primary biliary cholangitis Normal Pulmonary fibrosis Hepatocellular carcinoma Pulmonary systemic sclerosis

10x 3' v3 10x 3' v2