Homo sapiens

Pulmonary ionocyte Serous cell of epithelium of bronchus Mast cell Vein endothelial cell Intermediate monocyte Myeloid dendritic cell Basophil Neutrophil Respiratory tract goblet cell Plasma cell B cell Vascular associated smooth muscle cell Capillary endothelial cell Pericyte Club cell Non-classical monocyte Pulmonary alveolar type 2 cell Plasmacytoid dendritic cell Alveolar adventitial fibroblast Cd8-positive, alpha-beta t cell Pulmonary alveolar type 1 cell Endothelial cell of lymphatic vessel Natural killer cell Macrophage Bronchial smooth muscle cell Monocyte Mature nk t cell Basal cell Classical monocyte Mesothelial cell Adventitial cell Cd4-positive, alpha-beta t cell Lung multiciliated epithelial cell Endothelial cell of artery

Lung

61-year-old stage 59-year-old stage 60-year-old stage

Normal

Female Male

10x 3' v3 Smart-seq2

Cell

Homo sapiens

Fibroblast Pulmonary ionocyte Effector memory cd4-positive, alpha-beta t cell Mesothelial cell of pleura Effector memory cd8-positive, alpha-beta t cell Vein endothelial cell Intermediate monocyte Alveolar macrophage Epithelial cell Plasma cell Dendritic cell B cell Megakaryocyte Vascular associated smooth muscle cell Cd1c-positive myeloid dendritic cell Capillary endothelial cell Naive thymus-derived cd4-positive, alpha-beta t cell Mucus secreting cell Myeloid leukocyte Pericyte Myofibroblast cell Club cell Naive thymus-derived cd8-positive, alpha-beta t cell Non-classical monocyte Plasmacytoid dendritic cell, human Pulmonary alveolar type 2 cell Lung goblet cell Lymphocyte Respiratory basal cell Tracheobronchial serous cell Pulmonary alveolar type 1 cell Endothelial cell of lymphatic vessel Natural killer cell Macrophage Bronchial smooth muscle cell Ciliated cell Monocyte Pulmonary interstitial fibroblast Mature nk t cell Basal cell Classical monocyte Lung multiciliated epithelial cell Pulmonary neuroendocrine cell Endothelial cell Myeloid dendritic cell, human Endothelial cell of artery

Lung Blood

75-year-old stage 51-year-old stage 46-year-old stage

Normal

Female Male

10x 3' v2

Cell

Homo sapiens

Fibroblast Astrocyte Gabaergic neuron Vein endothelial cell Smooth muscle cell Oligodendrocyte precursor cell Oligodendrocyte Capillary endothelial cell Pericyte Glutamatergic neuron Perivascular macrophage Microglial cell T cell Endothelial cell of artery

Dorsolateral prefrontal cortex

78-year-old stage 83-year-old stage 81-year-old stage 90 year-old and over stage 79-year-old stage 88-year-old stage 87-year-old stage 84-year-old stage

Cognitive disorder Normal Alzheimer disease

Female Male

10x multiome

Nucleus

Mus musculus

Myotendinous junction nucleus Fibro/adipogenic progenitor cell Schwann cell Smooth muscle cell Blood vessel endothelial cell Intermediate muscle cell Type iia muscle cell Pericyte Neuromuscular junction nucleus Skeletal muscle satellite stem cell Type iix muscle cell Lymphocyte Adipocyte Perineurial cell Tendon cell Microvascular endothelial cell Macrophage Type iib muscle cell

Skeletal muscle tissue of tibialis anterior Gastrocnemius

Prime adult stage

Lesion of sciatic nerve Normal

Male

10x 3' v3

Nucleus

Homo sapiens

Transit amplifying cell Neoplastic cell Intestinal enteroendocrine cell Tuft cell Goblet cell Abnormal cell Gut absorptive cell Intestinal epithelial cell Intestinal crypt stem cell of colon

Ascending colon Sigmoid colon Transverse colon Hepatic flexure of colon Descending colon Hepatic cecum Rectum

54-year-old stage 62-year-old stage 73-year-old stage 72-year-old stage 53-year-old stage 57-year-old stage 70-year-old stage 59-year-old stage 58-year-old stage 50-year-old stage 64-year-old stage 68-year-old stage 60-year-old stage 67-year-old stage 65-year-old stage 71-year-old stage

Colon sessile serrated adenoma/polyp Tubulovillous adenoma Tubular adenoma Colorectal neoplasm Hyperplastic polyp Normal

Female Male

Trudrop

Cell

Homo sapiens

Myeloid cell Stromal cell B cell Mature t cell Immature t cell

Myasthenia gravis

10x 3' v3 10x 5' v2

Homo sapiens

Pulmonary alveolar epithelial cell Ionocyte Epithelial cell Tuft cell Club cell Hepatocyte Goblet cell Ciliated epithelial cell Neuroendocrine cell Basal cell

Adrenal gland Lung Pleural effusion Liver Brain Bone spine Axilla Lymph node

62-year-old stage 78-year-old stage 73-year-old stage 74-year-old stage 72-year-old stage 85-year-old stage 81-year-old stage 57-year-old stage 82-year-old stage 70-year-old stage 55-year-old stage 75-year-old stage 79-year-old stage 64-year-old stage 68-year-old stage 77-year-old stage 69-year-old stage 76-year-old stage 80-year-old stage 84-year-old stage 67-year-old stage 65-year-old stage 71-year-old stage 44-year-old stage 47-year-old stage

Normal Lung adenocarcinoma Small cell lung carcinoma

Female Male

10x 3' transcription profiling 10x 3' v3 10x 3' v2

Cell

Homo sapiens

Gabaergic neuron Mature microglial cell Oligodendrocyte precursor cell Oligodendrocyte Mature astrocyte Glutamatergic neuron Endothelial cell

Superior frontal gyrus

80 year-old and over stage 72-year-old stage 82-year-old stage 50-year-old stage 77-year-old stage 87-year-old stage 60-year-old stage 71-year-old stage

Normal Alzheimer disease

Male

10x 3' v2

Nucleus

Homo sapiens

Fibroblast Enteroendocrine cell Colon epithelial cell Enterocyte Vein endothelial cell Hematopoietic cell Epithelial cell Interstitial cell of cajal Enteric smooth muscle cell Pericyte Myofibroblast cell Intestine goblet cell Mesodermal cell Progenitor cell Endothelial cell of lymphatic vessel Erythroblast Mesothelial cell Enteric neuron Neural crest cell Stem cell Endothelial cell of artery

Duodeno-jejunal junction Ileum Colon

Carnegie stage 19 Carnegie stage 18 10th week post-fertilization stage Carnegie stage 23 Carnegie stage 22 Carnegie stage 17

Normal

10x 3' v2

Cell

Homo sapiens

Fibroblast Astrocyte Gabaergic neuron Oligodendrocyte precursor cell Oligodendrocyte Pericyte Somatomotor neuron Lymphocyte Ependymal cell Glutamatergic neuron Central nervous system macrophage Microglial cell Endothelial cell

Lumbar spinal cord

73-year-old stage 83-year-old stage 75-year-old stage 68-year-old stage 80-year-old stage 67-year-old stage

Amyotrophic lateral sclerosis Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

Retinal rod cell

Retina

70-year-old stage 79-year-old stage 77-year-old stage 65-year-old stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Retinal ganglion cell Off-bipolar cell Retinal rod cell Astrocyte Glial cell Gabaergic amacrine cell Precursor cell Amacrine cell Retina horizontal cell Retinal progenitor cell Photoreceptor cell Interneuron Retinal cone cell On-bipolar cell Mueller cell Microglial cell Bipolar neuron

Normal

Mixed sex

10x 3' v1