Homo sapiens

T cell Effector cd8-positive, alpha-beta t cell Natural killer cell Gamma-delta t cell Activated cd4-positive, alpha-beta t cell Mature nk t cell Cd8-positive, alpha-beta t cell Cd8-positive, alpha-beta memory t cell Group 3 innate lymphoid cell T-helper 17 cell Cd4-positive, cd25-positive, alpha-beta regulatory t cell Cd4-positive, alpha-beta t cell T follicular helper cell

Colorectum

69-year-old stage 91-year-old stage 42-year-old stage 89-year-old stage 71-year-old stage 53-year-old stage 61-year-old stage 52-year-old stage 48-year-old stage 56-year-old stage 55-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 90-year-old stage 51-year-old stage 57-year-old stage 72-year-old stage 81-year-old stage 49-year-old stage 35-year-old stage 58-year-old stage 59-year-old stage 67-year-old stage 77-year-old stage 64-year-old stage 45-year-old stage 62-year-old stage 70-year-old stage 60-year-old stage 78-year-old stage 36-year-old stage 47-year-old stage 76-year-old stage 73-year-old stage

Normal Colon adenocarcinoma

Female Male

10x 3' v3 10x 3' v2

Cell

Mus musculus

Club cell Respiratory tract goblet cell Endo-epithelial cell Pulmonary alveolar type 1 cell Lung endothelial cell Pulmonary alveolar type 2 cell

Embryo

Theiler stage 22 Theiler stage 27 Theiler stage 24 Theiler stage 18 Theiler stage 25 Theiler stage 16 Theiler stage 17 Theiler stage 15 Theiler stage 19 Theiler stage 26 Theiler stage 20 Theiler stage 21 Theiler stage 23

Normal

Female Male

Sci-rna-seq3

Nucleus

Homo sapiens

Leukocyte Neural cell Gut endothelial cell Enteric smooth muscle cell Intestinal epithelial cell Mesothelial cell Pericyte Myofibroblast cell Fibroblast

Hindgut Ileum Colon

19th week post-fertilization stage 21st week post-fertilization stage 23rd week post-fertilization stage 13th week post-fertilization stage 14th week post-fertilization stage 20th week post-fertilization stage 17th week post-fertilization stage 16th week post-fertilization stage 10th week post-fertilization stage 18th week post-fertilization stage Carnegie stage 22 11th week post-fertilization stage

Normal

Female Male

10x 3' v3

Cell

Homo sapiens

T cell Natural killer cell Gamma-delta t cell Activated cd4-positive, alpha-beta t cell Mature nk t cell Cd4-positive helper t cell Effector memory cd4-positive, alpha-beta t cell Lymphocyte Cd8-positive, alpha-beta memory t cell Regulatory t cell Activated cd8-positive, alpha-beta t cell Cd4-positive, alpha-beta t cell Effector memory cd8-positive, alpha-beta t cell

Breast

Adult stage Prime adult stage

Normal

Female

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Neutrophil Club cell Dendritic cell, human Natural killer cell Pulmonary capillary endothelial cell Myeloid dendritic cell, human Mature nk t cell Mast cell Cd8-positive, alpha-beta t cell Pancreatic acinar cell Basal cell Classical monocyte Smooth muscle cell Plasmacytoid dendritic cell, human Lung multiciliated epithelial cell Lung macrophage Regulatory t cell Pulmonary alveolar type 1 cell Lung endothelial cell Fibroblast of lung Plasma cell Cd4-positive, alpha-beta t cell Mesothelial cell B cell Pulmonary alveolar type 2 cell Lung pericyte Non-classical monocyte

Upper lobe of left lung

83-year-old stage

Covid-19

Male

10x 3' v3

Cell

Callithrix jacchus

Oligodendrocyte precursor cell Oligodendrocyte Vascular leptomeningeal cell Pvalb chandelier gabaergic interneuron Lamp5 gabaergic interneuron Microglial cell Vip gabaergic interneuron L2/3-6 intratelencephalic projecting glutamatergic neuron L5 extratelencephalic projecting glutamatergic cortical neuron L6b glutamatergic cortical neuron Pvalb gabaergic interneuron Near-projecting glutamatergic cortical neuron Cerebral cortex endothelial cell Caudal ganglionic eminence derived interneuron Sncg gabaergic interneuron Astrocyte of the cerebral cortex Sst gabaergic interneuron Corticothalamic-projecting glutamatergic cortical neuron

Middle temporal gyrus

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Sst gabaergic interneuron

Dorsolateral prefrontal cortex

69-year-old stage 75-year-old stage 42-year-old stage 89-year-old stage 87-year-old stage 85-year-old stage 88-year-old stage 68-year-old stage 29-year-old stage 84-year-old stage 82-year-old stage 50-year-old stage 80-year-old stage 72-year-old stage 81-year-old stage 80 year-old and over stage 77-year-old stage 86-year-old stage 70-year-old stage 78-year-old stage 83-year-old stage

Normal Dementia

Female Male

10x multiome 10x 3' v3

Nucleus

Callithrix jacchus

Oligodendrocyte

Dorsolateral prefrontal cortex Parietal cortex Primary visual cortex Temporal cortex Prefrontal cortex Temporal lobe Primary somatosensory cortex Primary auditory cortex Brodmann (1909) area 23 Primary motor cortex Secondary visual cortex

Prime adult stage

Normal

Female Male

10x 3' v3

Nucleus

Homo sapiens

Endothelial cell Lymphocyte Glial cell Pericyte Myofibroblast cell Fibroblast

Ileal epithelium Small intestine Ileum Ileum lamina propria Lamina propria of small intestine

Sixth decade stage Fifth decade stage Third decade stage Seventh decade stage Fourth decade stage Eighth decade stage

Normal Crohn disease

Female Male

10x 3' v3 10x 3' v2

Cell

Homo sapiens

Central nervous system macrophage Glutamatergic neuron Oligodendrocyte precursor cell Perivascular cell Endothelial cell Oligodendrocyte Microglial cell Pericyte Astrocyte Gabaergic neuron

Primary motor cortex

75-year-old stage 68-year-old stage 80-year-old stage 67-year-old stage 73-year-old stage 83-year-old stage

Amyotrophic lateral sclerosis Normal

Female Male

10x multiome 10x 3' v3

Nucleus

Homo sapiens

T cell Neutrophil Hepatocyte Natural killer cell Endothelial cell Mast cell Plasmacytoid dendritic cell Cholangiocyte Plasma cell Malignant cell B cell Conventional dendritic cell Fibroblast Mononuclear phagocyte

Liver

53-year-old stage 39-year-old stage 56-year-old stage 70-year-old stage 46-year-old stage

Metastatic malignant neoplasm Colorectal carcinoma Normal

Female Male

Bd rhapsody whole transcriptome analysis

Cell

Homo sapiens

Trophoblast giant cell Extravillous trophoblast Placental villous trophoblast Syncytiotrophoblast cell

Decidua Placenta Decidua basalis

Carnegie stage 14 13th week post-fertilization stage 9th week post-fertilization stage Carnegie stage 23 10th week post-fertilization stage Carnegie stage 22 Carnegie stage 16 Carnegie stage 18 11th week post-fertilization stage

Normal

Female

10x multiome 10x 3' v3 10x 3' v2

Nucleus Cell